Structural Classification of Proteins

Root: scop

Classes:

All alpha proteins [46456] (258)
1. Globin-like [46457] (2)
  core: 6 helices; folded leaf, partly opened
2. Long alpha-hairpin [46556] (19)
  2 helices; antiparallel hairpin, left-handed twist
3. Type I dockerin domain [63445] (1)
  tandem repeat of two calcium-binding loop-helix motifs, distinct from the EF-hand
4. LEM/SAP HeH motif [63450] (5)
  helix-extended loop-helix; parallel helices
5. RPB6/omega subunit-like [63561] (1)
  core: 2 helices and adjacent loops
6. KRAB domain (Kruppel-associated box) [109639] (1)
  2 helices: one short, one long; aromatic-rich iterface
7. Cytochrome c [46625] (1)
  core: 3 helices; folded leaf, opened
8. DNA/RNA-binding 3-helical bundle [46688] (14)
  core: 3-helices; bundle, closed or partly opened, right-handed twist; up-and down
9. Another 3-helical bundle [81602] (5)
  topologically similar to the DNA/RNA-binding bundles; distinct packing
10. RuvA C-terminal domain-like [46928] (9)
  3 helices; bundle, right-handed twist
11. S13-like H2TH domain [81297] (1)
  core: 3-4 helices
12. Putative DNA-binding domain [46954] (1)
  core: 3 helices; architecture is similar to that of the "winged helix" fold but topology is different
13. Spectrin repeat-like [46965] (15)
  3 helices; bundle, closed, left-handed twist; up-and-down
14. immunoglobulin/albumin-binding domain-like [46996] (10)
  3 helices; bundle, closed, left-handed twist; up-and-down; mirror topology to the spectrin-like fold
15. Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex [47004] (1)
  3 helices; bundle, closed, right-handed twist; up-and-down
16. ChaB-like [140375] (1)
  3 helices, the first one is shorter than the other two; bundle, capped by a small, C-terminal beta-hairpin
17. Protozoan pheromone-like [47013] (2)
  3 helices; bundle, closed, left-handed twist, up-and-down
18. Acyl-CoA binding protein-like [47026] (2)
  core: 3 helices; bundle, closed, left-handed twist; up-and-down
19. Kix domain of CBP (creb binding protein) [47039] (1)
  3 helices; bundle, partly opened
20. RAP domain-like [47044] (1)
  3 helices, the first one is shorter than the other two; bundle, partly opened
21. VHP, Villin headpiece domain [47049] (1)
  3 short helices; irregular array
22. BSD domain-like [140382] (1)
  core: 3 helices; triangular array; the extra N-terminal and C-terminal helices form a coiled coil structure
23. TAF(II)230 TBP-binding fragment [47054] (1)
  3 short helices; irregular array
24. S15/NS1 RNA-binding domain [47059] (1)
  3 helices; irregular array
25. Frizzled cysteine-rich domain [63500] (1)
  Core: 3 helices; irregular array; disulfide-rich
26. T4 endonuclease V [47076] (1)
  3 helices; irregular array
27. Fertilization protein [47081] (1)
  core: 3 helices; bundle, closed, right-handed twist; up-and-down
28. PGBD-like [47089] (1)
  core: 3 helices; bundle, closed, left-handed twist; parallel
29. HMG-box [47094] (1)
  3 helices; irregular array
30. Histone-fold [47112] (1)
  core: 3 helices; long middle helix is flanked at each end with shorter ones
31. Open three-helical up-and-down bundle [47143] (6)
  core: 3 helices; bundle, open
32. beta-catenin-interacting protein ICAT [81729] (1)
  core: 3 helices; irregular array
33. DNA polymerase III theta subunit-like [116730] (1)
  3 helices; irregular array
34. Four-helical up-and-down bundle [47161] (27)
  core: 4 helices; bundle, closed or partly opened, left-handed twist; up-and-down
35. PTS-regulatory domain, PRD [63519] (1)
  core: 4 helices; bundle, closed, right-handed twist; 1 crossover connection
36. Ferritin-like [47239] (4)
  core: 4 helices; bundle, closed, left-handed twist; 1 crossover connection
37. 4-helical cytokines [47265] (1)
  core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
38. Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases [47322] (1)
  core: 4 helices; bundle; one loop crosses over one side of the bundle
39. Acyl carrier protein-like [47335] (3)
  4 helices, bundle; helix 3 is shorter than others; up-and-down
40. Bromodomain-like [47363] (10)
  4 helices; bundle; minor mirror variant of up-and-down topology
41. ROP-like [47379] (8)
  4 helices; dimer of identical alpha-hairpin subunits; bundle, closed, left-handed twist
42. Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit [47390] (1)
  4 helices; bundle, closed, right-handed twist
43. Soluble domain of poliovirus core protein 3a [89042] (1)
  4 helices; bundle, closed, right-handed twist
44. Transcription factor IIA (TFIIA), alpha-helical domain [47395] (1)
  4 helices; bundle, closed, right-handed twist
45. Ectatomin subunits [47400] (1)
  4 helices; bundle, closed, left-handed twist
46. Dimerisation interlock [47405] (4)
  4 helices; bundle, closed, right-handed twist
47. lambda repressor-like DNA-binding domains [47412] (1)
  core: 4 helices; folded leaf, closed
48. Signal peptide-binding domain [47445] (1)
  4 helices; orthogonal array
49. A DNA-binding domain in eukaryotic transcription factors [47453] (1)
  4 helices; the long C-terminal helix protrudes from the domain and binds to DNA
50. HLH-like [47458] (2)
  4-helices; bundle, closed, left-handed twist; 2 crossover connections
51. EF Hand-like [47472] (4)
  core: 4 helices; array of 2 hairpins, opened
52. CH domain-like [47575] (3)
  core: 4 helices: bundle
53. Domain of poly(ADP-ribose) polymerase [47586] (1)
  core: 4 helices: bundle; unusual topology
54. SWIB/MDM2 domain [47591] (1)
  core: 4 helices: open bundle; capped by two small 3-stranded beta-sheets
  duplication: consists of two structural repeats
55. Pre-protein crosslinking domain of SecA [81766] (1)
  core: 4 helices: bundle; flanked by two short beta-hairpins
  duplication: consists of two structural repeats
56. Ribbon-helix-helix [47597] (1)
  core: 4 helices; array of 2 hairpins, opened
57. Glutathione S-transferase (GST), C-terminal domain [47615] (1)
  core: 4 helices; bundle, closed, left-handed twist; right-handed superhelix
58. Methionine synthase domain-like [47643] (3)
  4 helices; bundle, left-handed twist; right-handed superhelix
59. KaiA/RbsU domain [101214] (1)
  4 helices; bundle, right-handed twist; right-handed superhelix
60. STAT-like [47654] (6)
  4 long helices; bundle, left-handed twist (coiled coil); right-handed superhelix
61. N-cbl like [47667] (4)
  4 helices; bundle, left-handed twist; left-handed superhelix
62. Replisome organizer (g39p helicase loader/inhibitor protein) [89063] (1)
  4 helices; bundle, right-handed twist; left-handed superhelix
63. Hypothetical protein YqbG [116914] (1)
  core: 4 helices; bundle, right-handed twist; left-handed superhelix
64. C-terminal domain of B transposition protein [47680] (1)
  4 helices; irregular array
65. HAND domain of the nucleosome remodeling ATPase ISWI [101223] (1)
  4 helices; irregular array
66. N-terminal, cytoplasmic domain of anti-sigmaE factor RseA [89068] (1)
  4 helices; irregular array
67. Anaphylotoxins (complement system) [47685] (1)
  4 helices; irregular array, disulfide-linked
68. Cytochrome c oxidase subunit h [47693] (1)
  4 helices; irregular array, disulfide-linked
69. Crustacean CHH/MIH/GIH neurohormone [81777] (1)
  4 helices; irregular array, disulfide-linked
70. C-terminal domain of DFF45/ICAD (DFF-C domain) [81782] (1)
  4 helices; folded leaf; right-handed superhelix
71. Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin [47698] (1)
  4 helices; folded leaf; right-handed superhelix
72. p53 tetramerization domain [47718] (1)
  core: 4 helices; bundle
73. Bcr-Abl oncoprotein oligomerization domain [69035] (1)
  core: 4 long helices; bundle
74. Domain of early E2A DNA-binding protein, ADDBP [47723] (1)
  4 helices; bundle, partly opened
75. IHF-like DNA-binding proteins [47728] (1)
  core: 4 helices; bundle, partly opened, capped with a beta-sheet
76. TraM-like [140580] (1)
  multihelical oligomeric protein; structure of whole subunit is not known; the N-terminal part is implicated in DNA binding, the middle region forms tetrameric parallel coiled coil, surrounded by the C-terminal helices
77. CO dehydrogenase ISP C-domain like [47740] (1)
  core: 4 helices, bundle
78. Protein HNS-dependent expression A; HdeA [47751] (1)
  4 helices; the three last helices form a bundle similar to that of the RuvA C-domain
79. PABP domain-like [63569] (2)
  4 helices; an orthogonal array
80. Chemotaxis receptor methyltransferase CheR, N-terminal domain [47756] (1)
  4 helices; an orthogonal array
81. Dcp2 domain-like [140585] (1)
  4 helices; orthogonal array of two alpha hairpins
82. Type III secretion system domain [140590] (1)
  core: 4 helices, orthogonal array; right-handed superhelix
83. YugE-like [116921] (1)
  4-helices; bundle; right-handed twist
84. PWI domain [101232] (1)
  4 helices; up-and-down bundle; topological similarity to the bromodomain-like and SAM domain-like folds
85. PAH2 domain [47761] (1)
  4 helices; open up-and-down bundle; binds alpha-helical peptides
86. Myosin phosphatase inhibitor 17kDa protein, CPI-17 [81789] (1)
  4 helices; open up-and-down bundle; flexible N-terminal tail
87. XPC-binding domain [101237] (1)
  4 helices; array
88. DinB/YfiT-like putative metalloenzymes [109853] (1)
  core: 4 helices; bundle, closed, left-handed twist; an unusual topology with a higher contact order
89. EspA/CesA-like [116926] (1)
  4 helices; bundle, closed, left ight-handed twist; interlocked (hetero)dimer of 2-helical subunits
90. NblA-like [109858] (1)
  4 helices; dimer of identical alpha-hairpin subunits; open bundle
91. EF2947-like [140606] (1)
  4 helices; "diamond" array; duplication: N-terminal and C-terminal pairs of helices are related by pseudo dyad
92. EB1 dimerisation domain-like [140611] (1)
  dimeric 4-helical bundle with a coiled coil at one end formed by the longer N-terminal helices
93. SAM domain-like [47768] (15)
  4-5 helices; bundle of two orthogonally packed alpha-hairpins; involved in the interactions with DNA and proteins
94. Retroviral matrix proteins [47835] (1)
  4-5 helices; right-handed superhelix
95. Flavivirus capsid protein C [101256] (1)
  core: 5 helices; right-handed superhelix; swapped dimer with the two long C-terminal helices
96. Hepatitis B viral capsid (hbcag) [47851] (1)
  5 helices; array; two long helices form a hairpin that dimerizes into a 4-helical bundle
97. Apolipophorin-III [47856] (1)
  5 helices; bundle, closed, left-handed twist
98. Methenyltetrahydrofolate cyclohydrolase-like [101261] (1)
  5 helices; bundle, closed, left-handed twist
99. A middle domain of Talin 1 [109879] (1)
  5 helices; bundle, closed, left-handed twist; helices 2-5 adopt the Four-helical up-and-down bundle fold (scop_cf 47161)
100. I/LWEQ domain [109884] (1)
  5 helices; bundle, closed, left-handed twist
101. RNA-binding protein She2p [116941] (1)
  5 helices; bundle, closed, left-handed twist; topological similarity to the middle domain of the L-aspartase-like fold (scop_cf 48556)
102. Hyaluronidase domain-like [140656] (2)
  5 helices; bundle, closed, left-handed twist; up-and-down (meander) topology
103. YoaC-like [140669] (1)
  5 helices; bundle, one crossover connection, the arrangement of the first four helices is similar to the KaiA/RbsU domain fold (scop_cf 101214)
104. Saposin-like [47861] (2)
  5 helices; folded leaf, closed
105. Annexin [47873] (1)
  5 helices; folded leaf, closed
106. Transducin (alpha subunit), insertion domain [47894] (1)
  5 helices; folded leaf
107. Wiscott-Aldrich syndrome protein, WASP, C-terminal domain [47911] (1)
  5 helices; irregular array; left-handed superhelix
108. Left-handed superhelix [47916] (3)
  core: 4-5 helices; bundle; left-handed superhelix
109. N-terminal domain of the delta subunit of the F1F0-ATP synthase [47927] (1)
  core: 5 helices; bundle
110. ERP29 C domain-like [47932] (2)
  5 helices; bundle
111. Functional domain of the splicing factor Prp18 [47937] (1)
  core: 5 helices; bundle
112. Retrovirus capsid protein, N-terminal core domain [47942] (1)
  core: 5 helices; bundle
113. Cyclin-like [47953] (1)
  core: 5 helices; one helix is surrounded by the others
114. Arp2/3 complex 21 kDa subunit ARPC3 [69059] (1)
  5 helices; one helix is surrounded by the others
115. RNase III domain-like [69064] (1)
  core: 5 helices; one helix is surrounded by the others
116. Ribosomal protein S7 [47972] (1)
  core: 5 helices; contains one more helix and a beta-hairpin outside the core
117. DNA polymerase III clamp loader subunits, C-terminal domain [48018] (1)
  core: 5 helices: bundle
118. PAP/OAS1 substrate-binding domain [81632] (1)
  core: 5-helical bundle; up-and-down; right-handed twist
119. Anti-sigma factor AsiA [69069] (1)
  core: 5 helices: orthogonal array
120. Antibiotic binding domain of TipA-like multidrug resistance regulators [89081] (1)
  5 helices: orthogonal array
121. Surp module (SWAP domain) [109904] (1)
  5 helices: irregular array
122. YgfY-like [109909] (1)
  5 helices; array; forms a tight dimer in crystals
123. Hypothetical protein YhaI [109914] (1)
  core: 5 helices; orthogonal array; folding similarity to the TipA-S domain (1ny9)
124. Hypothetical protein At3g22680 [109919] (1)
  5 helices; array; probable biological unit is a homodimer
125. SP0561-like [140682] (1)
  5 helices; array; includes extra N-terminal and C-terminal short strands forming parrallel beta-sheet ladder
126. YfmB-like [140687] (1)
  5 helices, array; buried N-terminal helix; some topological similarity (circular permutation?) to the Nucleotidyltransferase substrate binding subunit/domain (scop_sf 81593)
127. N-terminal domain of adenylylcyclase associated protein, CAP [101277] (1)
  6 helices: bundle; left-handed twist, up-and-down topology
128. IpaD-like [140692] (1)
  6 helices; bundle, up-and-down; can be divided into two four-helical bundles sharing two helices (3 and 6), which are twice longer than the rest
129. Iron-dependent repressor protein, dimerization domain [47978] (1)
  6 helices, homodimer of 3-helical domains
130. Glutamyl tRNA-reductase dimerization domain [69074] (1)
  6 helices, homodimer of 3-helical domains
131. GRIP domain [101282] (1)
  6 helices, homodimer of 3-helical domains
132. BAR/IMD domain-like [116747] (1)
  6 helices, homodimer of 3-helical domains
133. L27 domain [101287] (1)
  6 helices, heterodimer of 3-helical domains
134. Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain [109924] (1)
  dimer of 3-helical segments; consists of two subdomains: 4-helical bundle and coiled coil
135. Phage replication organizer domain [140712] (1)
  6 helices, homodimer of 3-helical domains
136. Mediator hinge subcomplex-like [140717] (1)
  6 helices; heterodimer of structurally similar subunits; the N-terminal hairpins form a four-helical bundle, whereas the C-terminal helices form coiled coil structure
137. DEATH domain [47985] (1)
  6 helices: closed bundle; greek-key; internal pseudo twofold symmetry
138. Fatty acid responsive transcription factor FadR, C-terminal domain [48007] (1)
  core: 6 helices: closed bundle; greek-key; internal pseudo twofold symmetry
139. AF0941-like [140725] (1)
  6 helices, arranged into two interconnected 3-helical bundles; can also be described as a 'kinked' four-helical bundle; right-handed superhelix
140. NusB-like [48012] (1)
  6 helices: bundle; one central helix is surrounded by 5 others
141. YutG-like [101306] (1)
  core: 6 helices; bundle; one central helix is surrounded by 5 others
142. N-terminal domain of DnaB helicase [48023] (1)
  6 helices: array
143. Invasion protein A (SipA) , C-terminal actin binding domain [101311] (1)
  6 helices: orthogonal array
144. Guanido kinase N-terminal domain [48033] (1)
  irregular array of 6 short helices
145. Scaffolding protein gpD of bacteriophage procapsid [48044] (1)
  core: 6 helices; one central helix is surrounded by 5 others
146. Hemocyanin, N-terminal domain [48049] (1)
  6 helices; bundle; one central helix is surrounded by 5 others
147. Di-copper centre-containing domain [48055] (1)
  multihelical
148. DBL homology domain (DH-domain) [48064] (1)
  multihelical; core: 5-helical bundle
149. LigA subunit of an aromatic-ring-opening dioxygenase LigAB [48075] (1)
  multihelical; contains compact array of 6 short helices
150. RuBisCo LSMT C-terminal, substrate-binding domain [81821] (1)
  multihelical; irregular array of long and short helices
151. Methyl-coenzyme M reductase alpha and beta chain C-terminal domain [48080] (1)
  multihelical bundle; contains buried central helix
152. YcfC-like [101321] (1)
  multihelical; contains two buried central helices
153. PA2201 C-terminal domain-like [140730] (1)
  multihelical; seven-helical bundle with buried central helix
154. Rv1873-like [140735] (1)
  multihelical; contains unusually short buried central helix
155. RUN domain-like [140740] (1)
  multihelical; 3-helical bundle similar to one half of the DEATH domain fold is flanked by two alpha-hairpins forming a four-helical bundle; the axes of the three-helical and four-helical bundles are aproximately orthogonal to each other
156. SipA N-terminal domain-like [140745] (1)
  multihelical; bundle; the last helix is buried inside the bundle
157. Transcription factor STAT-4 N-domain [48091] (1)
  multihelical; can be divided into two subdomains
158. Regulator of G-protein signaling, RGS [48096] (1)
  multihelical; consists of two all-alpha subdomains
  contains a 4-helical bundle with left-handed twist and up-and-down topology
159. SopE-like GEF domain [81831] (1)
  multihelical; consists of two all-alpha subdomains each containing a 3-helical bundle with right-handed twist
160. Variable surface antigen VlsE [74747] (1)
  multihelical; consists of two all-alpha subdomains; contains a 4-helical bundle with left-handed twist and up-and-down topology
161. YgfB-like [101326] (1)
  multihelical; consists of two tightly associated 3-helical bundles with different twists
162. Hypothetical protein MTH393 [101331] (1)
  multihelical; consists of two all-alpha subdomains; dimer
163. PG0816-like [140752] (1)
  multihelical; comprises two helical bundles, both are topologically similar to the RuvA C-terminal domain-like fold (scop_cf 46928)
164. Carbamoyl phosphate synthetase, large subunit connection domain [48107] (1)
  multihelical; consists of two all-alpha subdomains
  possible duplication: subdomains have similar topologies
165. Heme-dependent peroxidases [48112] (1)
  multihelical; consists of two all-alpha domains
166. Ribosomal protein L19 (L19e) [48139] (1)
  multihelical; consists of two different 3-helical domains connected by a long, partly helical linker
167. GatB/YqeY motif [89094] (1)
  multihelical; consists of two different alpha-helical bundles (4-helical and 3-helical)
168. YfbU-like [116959] (1)
  multihelical; consist of two subdomains; forms 24-mer with the N-terminal sudbomains packing around the 4-fold axis and the C-terminal domains interacting at the 2-fold and 3-fold axes
169. Hypothetical protein MPN330 [116964] (1)
  multihelical; consists of three different 4-helical bundles
170. HD-domain/PDEase-like [109603] (1)
  multihelical; consists of two different alpha-helical bundles
171. Superantigen MAM [101343] (1)
  multihelical; consists of two different alpha-helical bundles
172. Influenza virus matrix protein M1 [48144] (1)
  multihelical; consists of two different all-alpha subdomains, 4 helices each
173. DNA-glycosylase [48149] (1)
  multihelical; consists of two all-alpha domains
174. An anticodon-binding domain of class I aminoacyl-tRNA synthetases [48162] (1)
  multihelical; consists of two all-alpha domains
175. Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) [101352] (1)
  multihelical; consists of two all-alpha subdomains
176. R1 subunit of ribonucleotide reductase, N-terminal domain [48167] (1)
  multihelical consists of two all-alpha subdomains
  subdomain 1 (residues 10-100) is a 4-helical bundle
177. BEACH domain [81836] (1)
  multihelical, complex architecture
178. Cryptochrome/photolyase FAD-binding domain [48172] (1)
  multihelical; consists of two all-alpha subdomains
179. 6-phosphogluconate dehydrogenase C-terminal domain-like [48178] (1)
  multihelical; common core is formed around two long antiparallel helices related by (pseudo) twofold symmetry
180. Uteroglobin-like [48200] (1)
  multihelical
181. alpha/alpha toroid [48207] (5)
  multihelical; up to seven alpha-hairpins are arranged in closed circular array; there may be sequence similarities between different superfamilies
182. Citrate synthase [48255] (1)
  multihelical; consists of two all-alpha domains
183. Cytochrome P450 [48263] (1)
  multihelical
184. Flagellar transcriptional activator FlhD [63591] (1)
  multihelical; forms intertwined dimer of identical 5-helical subunits
185. Ribosomal protein L7/12, oligomerisation (N-terminal) domain [48299] (1)
  multihelical; intertwined tetramer
186. Class II MHC-associated invariant chain ectoplasmic trimerization domain [48304] (1)
  multihelical; intertwined trimer of identical 3-helical subunits
187. Aldehyde ferredoxin oxidoreductase, C-terminal domains [48309] (1)
  multihelical; consists of two all-alpha domains
188. Acid phosphatase/Vanadium-dependent haloperoxidase [48316] (1)
  multihelical; core: 5-helical bundle; binds cofactor at the beginning of third helix
189. BRCA2 helical domain [81871] (1)
  multihelical; contains a 3-helical bundle surrounded by several shorter helices
190. BRCA2 tower domain [81877] (1)
  multihelical; contains a 3-helical Hin recombinase-like subdomain and two long dimerisation helices
191. H-NS histone-like proteins [81274] (1)
  multihelical oligomeric protein; structure of whole subunit is not known yet but are probably composed of three different domains
192. Sigma2 domain of RNA polymerase sigma factors [88945] (1)
  multihelical; consists of a conserved 4-helical core and a variable insert subdomain
193. DNA repair protein MutS, domain III [48333] (1)
  multihelical; consists of 2 all-alpha subdomains
194. Helical scaffold and wing domains of SecA [81885] (1)
  multihelical; consists of 2 all-alpha subdomains
195. all-alpha NTP pyrophosphatases [101385] (1)
  multihelical: dimeric 4-helical bundle surrounded by other helices; oligomerizes further in a tetramer
196. Hsp90 co-chaperone CDC37 [101390] (1)
  multihelical; consists of 2 all-alpha subdomains connected by a long helix
197. Nop domain [89123] (1)
  multihelical; array of longer and shorter helices; contains an alpha-hairpin dimerisation subdomain
198. YidB-like [140803] (1)
  multihelical; three strings of short helices are packed across one longer helix
199. Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain [48339] (1)
  multihelical; bundle of longer and shorter helices
200. A virus capsid protein alpha-helical domain [48344] (1)
  multihelical; three-helical bundle in the core is surrounded by non-conserved helices
201. P40 nucleoprotein [101398] (1)
  multihelical; consists of two subdomains
202. Rhabdovirus nucleoprotein-like [140808] (1)
  multihelical, consist of two helical domains; each domain contains a buried helix
203. GTPase activation domain, GAP [48349] (1)
  multihelical
204. Ras GEF [48365] (1)
  multihelical
205. Telomeric repeat binding factor (TRF) dimerisation domain [63599] (1)
  multihelical; can be divided into an alpha-alpha superhelix domain and a long alpha-hairpin dimerization domain
206. Poly A polymerase C-terminal region-like [81890] (1)
  multihelical; can be divided into three subdomains (neck, body and tail)
207. alpha-alpha superhelix [48370] (23)
  multihelical; 2 (curved) layers: alpha/alpha; right-handed superhelix
208. GUN4-like [140868] (1)
  multihelical; open array, trapping inside an extended region before the C-terminal helix
209. Lipoxigenase [48483] (1)
  multihelical
  large nearly all-alpha domain
210. gene 59 helicase assembly protein [48492] (1)
  multihelical; consists of two all-alpha subdomains
211. Tetracyclin repressor-like, C-terminal domain [48497] (1)
  multihelical; interlocked (homo)dimer
212. Skp1 dimerisation domain-like [81384] (1)
  multihelical; interlocked heterodimer with F-box proteins
213. F-box domain [81385] (1)
  multihelical; interlocked heterodimer with the Skp1 dimerisation domain
214. Nuclear receptor ligand-binding domain [48507] (1)
  multihelical; 3 layers or orthogonally packed helices
215. Phospholipase C/P1 nuclease [48536] (1)
  multihelical
216. ATP-dependent DNA ligase DNA-binding domain [117017] (1)
  multihelical; duplication: contains two intertwined structural repeats related by pseudo twofold symmetry
217. DNA primase DnaG, C-terminal domain [117022] (1)
  multihelical; segment-swapped dimer
218. PriB N-terminal domain-like [140913] (1)
  multihelical bundle; contains buried central helix; also includes the PriA interface-forming insert subdomain (alpha+beta)
219. VPS9 domain [109992] (1)
  multihelical; consist of two subdomains
220. Triger factor/SurA peptide-binding domain-like [109997] (1)
  multihelical; irregular array of long and short helices
221. DNA terminal protein [140918] (1)
  multihelical, open array; contains the C-terminal four-helical bundle, left-handed superhelix
222. Glycolipid transfer protein, GLTP [110003] (1)
  multihelical; 2 layers or orthogonally packed helices
223. Hypothetical protein MG354 [110008] (1)
  multihelical bundle; contains buried central helix
224. Duffy binding domain-like [140923] (1)
  consist of two subdomains, each containing a three-helical bundle
225. Fic-like [140930] (1)
  multihelical; one central helix is surrounded by seven helices
226. Her-1 [110013] (1)
  multihelical; consists of two topologically similar alpha-helical bundles
227. ERO1-like [110018] (1)
  multihelical; consists of 2 four-helical bundles
228. Serum albumin-like [48551] (1)
  multihelical; one domain consists of two similar disulfide-linked subdomains
229. L-aspartase-like [48556] (1)
  multihelical, consists of three all-alpha domains
230. Formin homology 2 domain (FH2 domain) [101446] (1)
  multihelical, consists of three all-alpha domains
231. Terpenoid synthases [48575] (1)
  multihelical; core: 8 helices (C-J) are arranged in 2 parallel layers
232. GroEL equatorial domain-like [48591] (1)
  multihelical; 8 helices arranged in 2 parallel layers
233. TorD-like [89154] (1)
  multihelical; bundle
234. Chorismate mutase II [48599] (1)
  multihelical; core: 6 helices, bundle
235. Peridinin-chlorophyll protein [48607] (1)
  multihelical: forms a boat-shaped protein shell around cofactors
236. Heme oxygenase-like [48612] (1)
  multihelical; bundle
237. Indolic compounds 2,3-dioxygenase-like [140958] (1)
  multihelical; bundle, contains interrupted helices
238. AhpD-like [69117] (1)
  multihelical; contains 4-helical bundle and 2-helical arm
239. Double Clp-N motif [81922] (1)
  multihelical; array
240. Orange carotenoid protein, N-terminal domain [81929] (1)
  multihelical; array
241. Citrobacter dihydroxyacetone kinase extra ATP-binding domain [101472] (1)
  multihelical; bundle
242. ADP-ribosylglycohydrolase [101477] (1)
  multihelical; bundle
243. Topoisomerase V catalytic domain-like [140978] (1)
  multihelical; irregular array; contains small amount of beta-structure and a 3-helical bundle with a variant homeofomain-like fold and HTH motif (scop_cf 46688)
244. PTPA-like [140983] (1)
  multihelical
245. FtsH protease domain-like [140989] (1)
  array of 6 helices and a 2-stranded beta-ribbon
246. Gametocyte protein Pfg27 [89161] (1)
  multihelical; bundle
247. N-terminal domain of bifunctional PutA protein [81934] (1)
  multihelical; array
248. Cysteine alpha-hairpin motif [47071] (1)
  core: alpha-hairpin crosslinked with two disulfides
249. Phospholipase A2, PLA2 [48618] (1)
  common core: 2 helices, disulfide-linked, and a calcium-binding loop
250. Fungal elicitin [48646] (1)
  5 helices: irregular disulfide-linked array; also contains a small beta-hairpin
251. Tetraspanin [48651] (1)
  5 helices: irregular disulfide-linked array; form homodimer
252. GDNF receptor-like [110034] (1)
  5 helices: irregular disulfide-linked array; topological similarity to the Fungal elicitin fold (scop_cf 48646)
253. Repressor of bacterial conjugation FinO [48656] (1)
  6 helices: irregular non-globular array; also contains two small beta-hairpins
254. Nuclear receptor coactivator interlocking domain [69124] (1)
  3 helices, non-globular array; forms interlocked heterodimers with its targets
255. Hermes dimerisation domain [140995] (1)
  multihelical, intertwinned dimer of two 4-helical strings
256. Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain [101488] (1)
  5 helices, non-globular array; wraps around the N-terminal tail of its target
257. Non-globular all-alpha subunits of globular proteins [48661] (12)
  not a true fold
258. Multiheme cytochromes [48694] (1)
  variable number of helices and little beta structure; not a true fold
All beta proteins [48724] (165)
1. Immunoglobulin-like beta-sandwich [48725] (27)
  sandwich; 7 strands in 2 sheets; greek-key
  some members of the fold have additional strands
2. Common fold of diphtheria toxin/transcription factors/cytochrome f [49379] (10)
  sandwich; 9 strands in 2 sheet; greek-key; subclass of immunoglobin-like fold
3. Prealbumin-like [49451] (7)
  sandwich; 7 strands in 2 sheets, greek-key
  variations: some members have additional 1-2 strands to common fold
4. HSP40/DnaJ peptide-binding domain [49492] (1)
  sandwich; 6 strands in 2 sheets
5. Penicillin-binding protein associated domain [69188] (1)
  sandwich; 6 strands in 2 sheets
6. alpha-Amylase inhibitor tendamistat [49497] (1)
  sandwich; 6 strands in 2 sheets
7. C-terminal domain of mollusc hemocyanin [81278] (1)
  six-stranded beta-sandwich, jelly-roll/greek-key topology
8. HPA-like [141085] (1)
  sandwich, 6 strands in 2 sheets; jelly-roll (truncated); also includes the pending PCSK9 V domain-like superfamily (the C-terminal domains of 2p4e and 2pmw)
9. L21p-like [141090] (1)
  core: sandwich, 6 strands in 2 sheets
10. Cupredoxin-like [49502] (2)
  sandwich; 7 strands in 2 sheets, greek-key
  variations: some members have additional 1-2 strands
11. Ctag/Cox11 [110110] (1)
  sandwich; 7 strands in 2 sheets, greek-key; permutation of the immunoglobulin-like fold
12. Atu1913-like [141098] (1)
  sandwich; 7 strands in two sheets, greek-key/jelly-roll; forms segment swapped dimers, swapping is probably facilitated by the helix insertion after strand 3
13. C2 domain-like [49561] (4)
  sandwich; 8 strands in 2 sheets; greek-key
14. TRAF domain-like [49598] (1)
  sandwich; 8 strands in 2 sheets; greek-key
15. Neurophysin II [49605] (1)
  sandwich; 8 strands in 2 sheets; meander
16. N-utilization substance G protein NusG, insert domain [82003] (1)
  sandwich; 8 strands in 2 sheets; meander
17. Nucleoplasmin-like/VP (viral coat and capsid proteins) [88632] (7)
  sandwich; 8 strands in 2 sheets; jelly-roll; some members can have additional 1-2 strands
  characteristic interaction between the domains of this fold allows the formation of five-fold and pseudo six-fold assemblies
18. gamma-Crystallin-like [49694] (1)
  sandwich; 8 strands in 2 sheets; greek-key
  duplication: has internal pseudo twofold symmetry
19. Lipase/lipooxygenase domain (PLAT/LH2 domain) [49722] (1)
  sandwich; 8 strands in 2 sheets; complex topology
  duplication: has weak internal pseudo twofold symmetry
20. Calpain large subunit, middle domain (domain III) [49757] (1)
  sandwich; 8 strands in 2 sheets; jelly-roll
21. Supernatant protein factor (SPF), C-terminal domain [101575] (1)
  sandwich; 8 strands in 2 sheets; jelly-roll; similarity to the Nucleoplasmin-like/VP fold
22. Hypothetical protein TM1070 [89231] (1)
  sandwich; 8 strands in 2 sheets; jelly-roll
23. Olfactory marker protein [63696] (1)
  sandwich; 8 strands in 2 sheets; jelly-roll
24. HSP20-like chaperones [49763] (1)
  sandwich; 8 strands in 2 sheets; greek-key
25. Heat shock protein 70kD (HSP70), peptide-binding domain [100919] (1)
  beta-sandwich: 8 strands in 2 sheets
26. Ecotin, trypsin inhibitor [49771] (1)
  sandwich; 8 strands in 2 sheets; complex topology with the crossing loops
27. PEBP-like [49776] (1)
  sandwich; 8 strands in 2 sheets; greek-key: partial topological similarity to immunoglobulin-like folds
28. Ganglioside M2 (gm2) activator [63706] (1)
  sandwich; 8 strands in 2 sheets; greek-key: partial topological similarity to immunoglobulin-like folds
29. Nicotinic receptor ligand binding domain-like [63711] (1)
  sandwich; 8 strands in 2 sheets; greek-key: partial topological similarity to immunoglobulin-like folds
30. Beta-galactosidase LacA, domain 3 [117099] (1)
  sandwich; 8 strands in 2 sheets
31. Galactose-binding domain-like [49784] (1)
  sandwich; 9 strands in 2 sheets; jelly-roll
32. Viral protein domain [49817] (1)
  sandwich; 9 strands in 2 sheets; jelly-roll; form trimers
33. Calcium-mediated lectin [82025] (1)
  sandwich; 9 strands in 2 sheets; greek-key
34. Dextranase, N-terminal domain [101595] (1)
  sandwich; 9 strands in 2 sheets; greek-key
35. Unnamed hypothetical protein [101600] (1)
  sandwich; 9 strands in 2 sheets; greek-key/jelly-roll
36. Superantigen (mitogen) Ypm [101605] (1)
  sandwich; 9 strands in 2 sheets; jelly-roll
37. ENV polyprotein, receptor-binding domain [49829] (1)
  sandwich; 9 strands in 2 sheets; greek-key; contains a few helices in loop regions
38. BTV NS2-like ssRNA-binding domain [110131] (1)
  sandwich; 9 strands in 2 sheets; unusual topology with 2 crossover loops
39. Virus attachment protein globular domain [49834] (1)
  sandwich, 10 strands in 2 sheets; greek-key
40. TNF-like [49841] (1)
  sandwich, 10 strands in 2 sheets; jelly-roll
41. CUB-like [49853] (3)
  sandwich, 10 strands in 2 sheets; jelly-roll
42. Hyaluronate lyase-like, C-terminal domain [49862] (1)
  sandwich, 10 strands in 2 sheets; "folded meander"
43. Cytolysin/lectin [63723] (1)
  sandwich, 10 strands in 2 sheets;
44. Putative glucosidase YicI, C-terminal domain [117124] (1)
  sandwich; 10 strands in two sheets
45. CsrA-like [117129] (1)
  sandwich; 10 strands in 2 sheets; intertwined dimer (segment-swapped, 5-stranded greek-key sandwich?)
46. Osmotin, thaumatin-like protein [49869] (1)
  sandwich; 11 strands in 2 sheets
47. SMAD/FHA domain [49878] (1)
  sandwich; 11 strands in 2 sheets; greek-key
48. Soluble secreted chemokine inhibitor, VCCI [49888] (1)
  sandwich; 11 strands in 2 sheets; greek-key
49. Baculovirus p35 protein [49893] (1)
  sandwich; 14 strands in 2 sheets; greek-key
50. Concanavalin A-like lectins/glucanases [49898] (1)
  sandwich; 12-14 strands in 2 sheets; complex topology
51. Supersandwich [49993] (3)
  sandwich; 18 strands in 2 sheets
52. Leukotriene A4 hydrolase N-terminal domain [63736] (1)
  duplication: two beta-sandwiches of similar topologies are fused together in a single three beta-sheet domain
53. EV matrix protein [50011] (1)
  consists of two beta-sandwich domains of similar topologies
54. Viral chemokine binding protein m3 [82045] (1)
  consists of two different beta-sandwich domains of partial topological similarity to immunoglobulin-like folds
55. gp9 [50016] (1)
  consists of two different beta-sandwich domains unrelated to other beta-sandwich folds
56. Flagellar hook protein flgE [117142] (1)
  consists of two different domains; d1: [complex fold made of bifurcated beta-sheets]; d2 (inserted into d1): [beta-sandwich; 8 strands in 2 sheets]
57. ISP domain [50021] (1)
  consists of two all-beta subdomains: conserved small domain has a rubredoxin-like fold; larger domain consists of 6 beta-stands packed in either sandwich of two 3-stranded sheets or closed barrel (n=6; S=8)
58. Obg-fold [82050] (1)
  this fold is formed by three glycine-rich regions inserted into a small 8-stranded beta-sandwich
  these regions form six left-handed collagen-like helices packed and H-bonded together
59. SH3-like barrel [50036] (18)
  barrel, partly opened; n*=4, S*=8; meander
  the last strand is interrupted by a turn of 3-10 helix
60. GroES-like [50128] (2)
  contains barrel, partly opened; n*=4, S*=8; meander
61. PDZ domain-like [50155] (1)
  contains barrel, partly opened; n*=4, S*=8; meander; capped by alpha-helix
62. N-terminal domains of the minor coat protein g3p [50175] (1)
  core: barrel, in some members open; n*=4, S*=8; meander
63. Sm-like fold [50181] (3)
  core: barrel, open; n*=4, S*=8; meander; SH3-like topology
64. Stringent starvation protein B, SspB [101737] (1)
  core: barrel, open; n*=4, S*=8; meander; SH3-like topology; some similarity to the Sm-like fold
65. Rof/RNase P subunit-like [101743] (1)
  core: barrel, open; n*=4, S*=8; meander; SH3-like topology; some similarity to the Sm-like fold
66. Hydrophobin II, HfbII [101750] (1)
  core: barrel, closed; n=4, S=8; complex topology; helix-containing crossover connection
67. Ribosomal protein L14 [50192] (1)
  barrel, closed; n=5, S=8, meander
68. OB-fold [50198] (12)
  barrel, closed or partly opened n=5, S=10 or S=8; greek-key
69. PRC-barrel domain [50345] (1)
  core: barrel, partly opened; n*=5, S*=8; meander
70. beta-Trefoil [50352] (8)
  barrel, closed; n=6, S=12; and a hairpin triplet; meander
  duplication: has internal pseudo threefold symmetry
71. Reductase/isomerase/elongation factor common domain [50412] (4)
  barrel, closed; n=6, S=10; greek-key
72. Elongation factor/aminomethyltransferase common domain [50464] (2)
  barrel, closed; n=6, S=10; greek-key
73. Split barrel-like [50474] (2)
  barrel; n=6, S=10; greek-key
74. Phage tail proteins [69278] (1)
  core: barrel; n=6, S=10; greek-key; topologically similar to the FMN-binding split barrel
75. Surface presentation of antigens (SPOA) [101800] (1)
  segment-swapped dimer forming two identical conjoint barrels (n=6, S=10) topologically similar to the FMN-binding split barrel
76. FMT C-terminal domain-like [50485] (1)
  barrel, open; n*=6, S*=10; greek-key
77. Trypsin-like serine proteases [50493] (1)
  barrel, closed; n=6, S=8; greek-key
  duplication: consists of two domains of the same fold
78. Replicase NSP9 [101815] (1)
  barrel; n=6, S=8, greek-key; similar to one trypsin-like protease barrel
79. mu transposase, C-terminal domain [50609] (1)
  barrel; n=6, S=8, greek-key
80. Domain of alpha and beta subunits of F1 ATP synthase-like [50614] (3)
  barrel, closed; n=6, S=8; greek-key
81. Small protein B (SmpB) [74981] (1)
  barrel, closed; n=6, S=8, greek-key, partial similarity to the OB-fold
82. Acid proteases [50629] (1)
  barrel, closed; n=6, S=10, complex topology
83. ValRS/IleRS/LeuRS editing domain [50676] (1)
  core: barrel, closed; n=6, S=8; topology is similar to that of the acid proteases barrel
84. Urease metallochaperone UreE, N-terminal domain [69286] (1)
  barrel, closed; n=6, S=8; a crossover loop topology
85. Double psi beta-barrel [50684] (2)
  barrel, closed; n=6, S=10; complex topology with crossover (psi) loops
86. Ribosomal protein L25-like [50714] (1)
  barrel, closed; n=6, S=10; complex topology
87. Core binding factor beta, CBF [50722] (1)
  barrel, closed; n=6, S=10; meander; capped at both ends by alpha-helices
88. PH domain-like barrel [50728] (2)
  barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix
89. Transcription factor IIA (TFIIA), beta-barrel domain [50783] (1)
  barrel, closed; n=6, S=12; mixed beta-sheet
90. Hcp1-like [141451] (1)
  barrel, closed; n=6, S=12; contains extra, non-barrel strand 7 at the C-terminus
91. Herpes virus serine proteinase, assemblin [50788] (1)
  core: barrel, closed; n=7, S=8; complex topology
92. PK beta-barrel domain-like [50799] (1)
  barrel, closed; n=7, S=10; complex topology
93. XRCC4, N-terminal domain [50808] (1)
  barrel, closed; n=7, S=10; order: 1234765; strands 1 and 5 are parallel to each other
94. HesB-like domain [89359] (1)
  barrel, closed; n=7, S=10; complex topology
95. Bacterial fluorinating enzyme, C-terminal domain [101851] (1)
  barrel, closed; n=7, S=10; greek-key topology; one overside connection
96. SPOC domain-like [100938] (1)
  barrel, closed; n=7, S=10; complex topology
97. BH3618-like [141456] (1)
  barrel, closed; n=7, S=10; meander
98. FAS1 domain [82152] (1)
  core: barrel, closed; n=7, S=12; meander
99. Lipocalins [50813] (1)
  barrel, closed or opened; n=8, S=12; meander
100. Streptavidin-like [50875] (8)
  barrel, closed; n=8, S=10; meander
101. Allene oxide cyclase-like [141492] (1)
  barrel, closed; n=8, S=10; meander; mirrored (reversed) topology to the Spreptavidin-like and Lipocalin-like folds
102. Cyclophilin-like [50890] (1)
  barrel, closed; n=8, S=10; complex topology
103. Oncogene products [50903] (1)
  barrel, closed; n=8, S=10; one overside connection
104. L,D-transpeptidase catalytic domain-like [141522] (1)
  barrel, closed; n=8, S=10; one overside connection
105. Sortase [63816] (1)
  barrel, closed; n=8, S=10; mixed sheet; two overside connections
106. PTSIIA/GutA-like [141529] (1)
  barrel, closed; n=8, S=12; mixed sheet; two overside connections; duplication: consists of two intertwinned structural repeats
107. Mannose 6-phosphate receptor domain [50910] (1)
  barrel, partly open; n*=8, S*=10; one psi loop
108. triple barrel [50915] (1)
  dimer of two non-identical subunits; forms two similar barrels, n=8, S=10 each, that are fused together with the formation of third barrel, n=6, S=8
109. 4-bladed beta-propeller [50922] (1)
  consists of four 4-stranded beta-sheet motifs; meander
110. 5-bladed beta-propeller [50933] (3)
  consists of five 4-stranded beta-sheet motifs; meander
111. 6-bladed beta-propeller [50938] (11)
  consists of six 4-stranded beta-sheet motifs; meander
112. 7-bladed beta-propeller [50964] (14)
  consists of seven 4-stranded beta-sheet motifs; meander
113. 8-bladed beta-propeller [50997] (3)
  consists of eight 4-stranded beta-sheet motifs; meander
  also found in some members of the WD40-repeat superfamily
114. Glycosyl hydrolase domain [51010] (1)
  folded sheet; greek-key
115. WW domain-like [51044] (3)
  core: 3-stranded meander beta-sheet
116. Head domain of nucleotide exchange factor GrpE [51063] (1)
  small mixed beta-sheet, 4 "generalized" strands
117. Coronavirus RNA-binding domain [110303] (1)
  coiled antiparallel beta-sheet of 5 strands, order 51324; complex topology, crossing loops
118. Ribonuclease domain of colicin E3 [63839] (1)
  twisted meander beta-sheet of 6 strands
119. NAC domain [101940] (1)
  core: twisted 7-stranded beta-sheet (half-barrel)
120. At5g01610-like [141561] (1)
  contains large meander beta-sheet bent into a scoop-like shape
121. Carbonic anhydrase [51068] (1)
  single sheet; 10 strands
122. Prokaryotic lipoproteins and lipoprotein localization factors [89391] (1)
  11 stranded sheet partly folded in a corner-like structure filled with a few short helices
123. Bacteriochlorophyll A protein [51080] (1)
  single sheet; 16 strands; meander
124. open-sided beta-meander [51086] (2)
  single sheet formed by beta-hairpin repeats; exposed on both sides in the middle
125. beta-Prism I [51091] (3)
  consists of 3 4-stranded sheets; strands are parallel to the 3-fold axis
  duplication: has internal pseudo threefold symmetry
126. beta-Prism II [51109] (1)
  consists of 3 4-stranded sheets; strands are perpendicular to the 3-fold axis
  duplication: consists of two domains of this fold
127. Single-stranded right-handed beta-helix [51125] (8)
  superhelix turns are made of parallel beta-strands and (short) turns
128. Single-stranded left-handed beta-helix [51160] (3)
  superhelix turns are made of parallel beta-strands and (short) turns
129. Double-stranded beta-helix [51181] (7)
  one turn of helix is made by two pairs of antiparallel strands linked with short turns
  has appearance of a sandwich of distinct architecture and jelly-roll topology
130. Triple-stranded beta-helix [69348] (1)
  (homo)trimer; each chain donates 3 beta-strands per turn of the helix
131. Triple beta-spiral [51224] (1)
  trimer formed by the interlocking beta-hairpin repeat units
132. Trimeric adhesin [101998] (1)
  trimer; contains two different beta-prism-like domains connected by an linker subdomain of less regular structure
133. beta-hairpin stack [69359] (1)
  Trp-rich beta-hairpin repeat units form helical structures of 3 units per turn
134. Barrel-sandwich hybrid [51229] (4)
  sandwich of half-barrel shaped beta-sheets
135. beta-clip [51268] (7)
  double-stranded ribbon sharply bent in two places; the ribbon ends form incomplete barrel; jelly-roll
136. PheT/TilS domain [56036] (1)
  core: 3 layers; contains beta-sandwich of unusual topology
137. C-terminal autoproteolytic domain of nucleoporin nup98 [82214] (1)
  multisheet protein with a mixture of beta-sandwich and beta-prism features
138. Pseudo beta-prism [141657] (1)
  beta-sandwich with one regular beta-sheet and the other beta-sheet bent in the middle with a set of aligned beta-bulges
139. SARS ORF9b-like [141665] (1)
  complex dimeric fold with three intersubunit beta-sheets packed around a single core
140. Adsorption protein p2 [89427] (1)
  multisheet protein containing partial beta-propeller and beta-sandwich regions
141. Baseplate structural protein gp8 [89432] (1)
  multisheet protein with a mixture of beta-sandwich and beta-barrel features
142. Hedgehog/intein (Hint) domain [51293] (1)
  complex fold made of five beta-hairpin units and a b-ribbon arc
143. LexA/Signal peptidase [51305] (1)
  complex fold made of several coiled beta-sheets; contains an SH3-like barrel
144. Cloacin translocation domain [69368] (1)
  complex fold made of several coiled beta-sheets
145. Mss4-like [51315] (1)
  complex fold made of several coiled beta-sheets
146. Cyanovirin-N [51321] (1)
  complex fold
147. Tp47 lipoprotein, N-terminal domain [82219] (1)
  complex fold; consists of two intertwined subdomains
148. Methuselah ectodomain [63876] (1)
  complex fold
149. Head-binding domain of phage P22 tailspike protein [51326] (1)
  complex fold made of bifurcated and partly folded beta-sheet
150. E2 regulatory, transactivation domain [51331] (1)
  complex fold made of bifurcated and coiled beta-sheets
151. MoeA N-terminal region -like [63881] (1)
  complex fold made of bifurcated and coiled b-sheets
152. MOSC N-terminal domain-like [141672] (1)
  complex fold; comprises a beta-hairpin and a meander 3-stranded sheet packed against beta-barrel: closed, n=5, S=8; contains three short helices
153. MAL13P1.257-like [141677] (1)
  complex fold; duplication: consists of two intertwinned structural repeats related by pseudo dyad
154. Composite domain of metallo-dependent hydrolases [51337] (1)
  pseudobarrel; mixed sheet of 7 strand folded upon itself and "buckled" by two beta-turns
155. Epsilon subunit of F1F0-ATP synthase N-terminal domain [51343] (1)
  pseudobarrel: sandwich of two sheets packed at a positive interstrand angle and interconnected with many short turns
156. N-terminal domain of MutM-like DNA repair proteins [81625] (1)
  pseudobarrel; capped on both ends by alpha-helices
157. Hypothetical protein YojF [89441] (1)
  pseudobarrel; capped at one end by an alpha-helix
158. DNA-binding pseudobarrel domain [101935] (1)
  core: barrel, open; n=7, S*=10; capped with helices at both ends; partial similarity to the AbrB/MazE/MraZ-like fold (scop_cf 89446)
159. Double-split beta-barrel [89446] (2)
  pseudobarrel; capped on both ends by alpha-helices
160. PUA domain-like [88696] (1)
  pseudobarrel; mixed folded sheet of 5 strands; order 13452; strand 1 and 3 are parallel to each other
161. AXH domain [102030] (1)
  pseudobarrel; some similarity to OB-fold
162. FimD N-terminal domain-like [141728] (1)
  pseudo barrel, capped by an alpha-helix; some topological similarity to the PRC-barrel domain (scop_sf 50346) and the N-terminal domain of Glutamine synthetase (scop_sf 54368)
163. HisI-like [141733] (1)
  pseudo barrel, capped by an alpha-helix; contains a beta-triangle structure on one side; some topological similarity to the Ribosomal protein L25-like fold (scop_cf 50714) and the N-terminal domain of Glutamine synthetase (scop_sf 54368)
164. MFPT repeat-like [141738] (1)
  consists of two similar pseudo barrel subdomains with structural similarity to a circularly permuted SAND domain (scop_fa 63764)
165. P-domain of calnexin/calreticulin [63886] (1)
  non-globular proline-rich hairpin
Alpha and beta proteins (a/b) [51349] (141)
Mainly parallel beta sheets (beta-alpha-beta units)
1. TIM beta/alpha-barrel [51350] (33)
  contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
  the first seven superfamilies have similar phosphate-binding sites
2. NAD(P)-binding Rossmann-fold domains [51734] (1)
  core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
  The nucleotide-binding modes of this and the next two folds/superfamilies are similar
3. FAD/NAD(P)-binding domain [51904] (1)
  core: 3 layers, b/b/a; central parallel beta-sheet of 5 strands, order 32145; top antiparallel beta-sheet of 3 strands, meander
4. Nucleotide-binding domain [51970] (1)
  3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32145; Rossmann-like
5. MurCD N-terminal domain [51983] (1)
  3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32145; incomplete Rossmann-like fold; binds UDP group
6. 7-stranded beta/alpha barrel [51988] (3)
  variant of beta/alpha barrel; parallel beta-sheet barrel, closed, n=7, S=8; strand order 1234567; some members may have fewer strands
7. PFL-like glycyl radical enzymes [51997] (1)
  contains: barrel, closed; n=10, S=10; accommodates a hairpin loop inside the barrel
8. The "swivelling" beta/beta/alpha domain [52008] (10)
  3 layers: b/b/a; the central sheet is parallel, and the other one is antiparallel; there are some variations in topology
  this domain is thought to be mobile in most multi-domain proteins known to contain it
9. Barstar-like [52037] (2)
  2 layers, a/b; parallel beta-sheet of 3 strands, order 123
10. MurF and HprK N-domain-like [63417] (2)
  core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1234; structural similarity of the MurF and HprK extends beyond the core.
11. Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [52046] (3)
  2 curved layers, a/b; parallel beta-sheet; order 1234...N; there are sequence similarities between different superfamilies
12. Ribosomal proteins L15p and L18e [52079] (1)
  core: three turns of irregular (beta-beta-alpha)n superhelix
13. SpoIIaa-like [52086] (2)
  core: 4 turns of a (beta-alpha)n superhelix
14. ClpP/crotonase [52095] (1)
  core: 4 turns of (beta-beta-alpha)n superhelix
15. BRCT domain [52112] (1)
  3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134
16. Lumazine synthase [52120] (1)
  3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134
17. Uracil-DNA glycosylase-like [52140] (1)
  3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134
18. Creatininase [102214] (1)
  3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134
19. DNA polymerase III psi subunit [102219] (1)
  3 layers, a/b/a; parallel beta-sheet of 4 strands, order 2134
20. Initiation factor IF2/eIF5b, domain 3 [52155] (1)
  3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134
21. Aminoacid dehydrogenase-like, N-terminal domain [53222] (1)
  core: 3 layers: a/b/a; parallel beta-sheet of 4 strands; 2134
22. Toprim domain [110454] (1)
  3 layers, a/b/a; parallel beta-sheet of 4 strands, order 2134
23. Ribosomal protein L13 [52160] (1)
  3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 3214
24. Ribosomal protein L4 [52165] (1)
  3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 1423
25. Nqo1 FMN-binding domain-like [142018] (1)
  3 layers, a/b/a; parallel beta-sheet of 4 strands, order 3214
26. Flavodoxin-like [52171] (15)
  3 layers, a/b/a; parallel beta-sheet of 5 strand, order 21345
27. Methylglyoxal synthase-like [52334] (1)
  3 layers, a/b/a; parallel beta-sheet of 5 strands, order 32145
28. Ferredoxin reductase-like, C-terminal NADP-linked domain [52342] (1)
  3 layers, a/b/a; parallel beta-sheet of 5 strands, order 32145
29. Adenine nucleotide alpha hydrolase-like [52373] (3)
  core: 3 layers, a/b/a ; parallel beta-sheet of 5 strands, order 32145
30. Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain [52417] (1)
  3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32145; Rossmann-like
31. Cryptochrome/photolyase, N-terminal domain [52424] (1)
  3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32145; Rossmann-like
32. DsrEFH-like [75168] (1)
  3 layers: a/b/a, core: parallel beta-sheet of 5 strands, order 43215
33. PIN domain-like [88722] (1)
  3 layers, a/b/a; core: parallel beta-sheet of 5 strands, order 32145
34. Ribose/Galactose isomerase RpiB/AlsB [89622] (1)
  3 layers: a/b/a, core: parallel beta-sheet of 5 strands, order 21354; topological similarity to a part of the arginase/deacetylase fold
35. alpha/beta knot [75216] (1)
  core: 3 layers: a/b/a, parallel beta-sheet of 5 strands, order 21435; contains a deep trefoil knot
36. PreATP-grasp domain [52439] (1)
  3 layers: a/b/a; parallel or mixed beta-sheet of 4 to 6 strands
  possible rudiment form of Rossmann-fold domain
37. DHS-like NAD/FAD-binding domain [52466] (1)
  3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like
38. Tubulin nucleotide-binding domain-like [52489] (1)
  3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456
39. Isochorismatase-like hydrolases [52498] (1)
  3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456
40. Dipeptide transport protein [63991] (1)
  3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; also contains a C-terminal alpha+beta subdomain
41. Homo-oligomeric flavin-containing Cys decarboxylases, HFCD [52506] (1)
  3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456
42. HAD-like [56783] (1)
  3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456
43. NagB/RpiA/CoA transferase-like [100949] (1)
  core: 3 layers: a/b/a; parallel or mixed beta-sheet of 6 strands, order 321456
44. Hypothetical protein MTH777 (MT0777) [75180] (1)
  3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456
45. Thiamin pyrophosphokinase, catalytic domain [63998] (1)
  3 layers: a/b/a; parallel beta-sheet of 6 strands, order 432156
46. Undecaprenyl diphosphate synthase [64004] (1)
  3 layers: a/b/a; parallel beta-sheet of 6 strands, order 342156
47. F420-dependent methylenetetrahydromethanopterin dehydrogenase (MTD) [102323] (1)
  3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213456
48. Thiamin diphosphate-binding fold (THDP-binding) [52517] (1)
  3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
49. P-loop containing nucleoside triphosphate hydrolases [52539] (1)
  3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes
50. PTS IIb component [52727] (1)
  3 layers: a/b/a, parallel beta-sheet of 6 strands, order 324156
51. DNA polymerase III chi subunit [102399] (1)
  3 layers, a/b/a; parallel beta-sheet of 7 strands, order 7165243
52. Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) [52732] (1)
  3 layers: a/b/a, parallel beta-sheet of 7 strands, order 3214567
53. CofD-like [142337] (1)
  3 layers: a/b/a, parallel beta-sheet of 7 strands, order 3214567; topological similarity to the CobT-like fold (scop_cf 52732)
54. MoCo carrier protein-like [102404] (1)
  3 layers: a/b/a, parallel beta-sheet of 7 strands, order 4321567
55. Methylesterase CheB, C-terminal domain [52737] (1)
  3 layers: a/b/a, parallel beta-sheet of 7 strands, order 3421567
56. Subtilisin-like [52742] (1)
  3 layers: a/b/a, parallel beta-sheet of 7 strands, order 2314567; left-handed crossover connection between strands 2 & 3
57. Indigoidine synthase A-like [110580] (1)
  core: 3 layers, a/b/a; parallel beta-sheet of 7 strands, order 2134756
58. Arginase/deacetylase [52767] (1)
  3 layers: a/b/a, parallel beta-sheet of 8 strands, order 21387456
59. Alpha-2,3/8-sialyltransferase CstII [102413] (1)
  3 layers: a/b/a; parallel beta-sheet of 8 strands, order 54321678
60. Cell-division inhibitor MinC, N-terminal domain [64042] (1)
  beta(2)-(alpha-beta)2-beta; 2 layers, a/b; mixed beta-sheet of 5 strands, order 12345; strands 1 & 5 are antiparallel to the rest
61. DTD-like [69499] (1)
  beta(2)-(alpha-beta)2-beta(3); 3 layers, a/b/b; some topological similarity to the N-terminal domain of MinC
62. CoA-dependent acyltransferases [52776] (1)
  core: 2 layers, a/b; mixed beta-sheet of 6 strands, order 324561; strands 3 & 6 are antiparallel to the rest
63. Phosphotyrosine protein phosphatases I-like [52787] (2)
  3 layers: a/b/a; parallel beta-sheet of 4 strands, order 2134
64. (Phosphotyrosine protein) phosphatases II [52798] (1)
  core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423
65. Rhodanese/Cell cycle control phosphatase [52820] (1)
  3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32451
66. Thioredoxin fold [52832] (2)
  core: 3 layers, a/b/a; mixed beta-sheet of 4 strands, order 4312; strand 3 is antiparallel to the rest
67. Peptidyl-tRNA hydrolase II [102461] (1)
  3 layers: a/b/a; mixed beta-sheet of 4 strands, order 2143, strand 4 is antiparallel to the rest
68. TK C-terminal domain-like [52921] (1)
  3 layers: a/b/a; mixed beta-sheet of 5 strands, order 13245, strand 1 is antiparallel to the rest
69. Pyruvate kinase C-terminal domain-like [52934] (2)
  3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32145, strand 5 is antiparallel to the rest
70. Anticodon-binding domain-like [52953] (5)
  3 layers: a/b/a; mixed beta-sheet of five strands, order 21345; strand 4 is antiparallel to the rest
71. MTH938-like [64075] (1)
  core: 3 layers, b+a/b/a ; the central mixed sheet of 5 strands: order 21534; strand 2 is antiparallel to the rest
72. Restriction endonuclease-like [52979] (3)
  core: 3 layers, a/b/a; mixed beta-sheet of 5 strands, order 12345; strands 2 &, in some families, 5 are antiparallel to the rest
73. Resolvase-like [53040] (2)
  Core: 3 layers: a/b/a; mixed beta-sheet of 5 strands, order 21345; strand 5 is antiparallel to the rest
74. IIA domain of mannose transporter, IIA-Man [53061] (1)
  3 layers: a/b/a; mixed beta-sheet of 5 strands, order 21345; strand 5 is antiparallel to the rest
75. Ribonuclease H-like motif [53066] (7)
  3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32145; strand 2 is antiparallel to the rest
76. Phosphorylase/hydrolase-like [53162] (7)
  core: 3 layers, a/b/a ; mixed sheet of 5 strands: order 21354; strand 4 is antiparallel to the rest; contains crossover loops
77. Molybdenum cofactor biosynthesis proteins [53217] (1)
  3 layers: a/b/a; mixed beta-sheet of 5 strands; order: 21354, strand 5 is antiparallel to the rest; permutation of the Phosphorylase/hydrolase-like fold
78. Bacterial fluorinating enzyme, N-terminal domain [102521] (1)
  3 layers: a/b/a; mixed beta-sheet of 6 strands; order: 213546, strand 5 is antiparallel to the rest; topological similarity to the MogA-like family fold
79. Caspase-like [52128] (1)
  3 layers, a/b/a; core: mixed beta-sheet of 6 strands, order 213456, strand 6 is antiparallel to the rest
80. Macro domain-like [52948] (1)
  3 layers: a/b/a; mixed beta-sheet of 6 strands, order 165243, strand 3 is antiparallel to the rest
81. MurD-like peptide ligases, peptide-binding domain [53243] (1)
  3 layers: a/b/a; mixed beta-sheet of 6 strands, order 126345; strand 1 is antiparallel to the rest
82. Phosphoglycerate mutase-like [53253] (1)
  core: 3 layers, a/b/a; mixed beta-sheet of 6 strands, order 324156; strand 5 is antiparallel to the rest
83. PRTase-like [53270] (1)
  core: 3 layers, a/b/a; mixed beta-sheet of 6 strands, order 321456; strand 3 is antiparallel to the rest
84. vWA-like [53299] (1)
  core: 3 layers, a/b/a; mixed beta-sheet of 6 strands, order 321456; strand 3 is antiparallel to the rest
85. Pyruvate-ferredoxin oxidoreductase, PFOR, domain III [53322] (1)
  3 layers: a/b/a; mixed beta-sheet of 6 strands, order 231456; strand 3 is antiparallel to the rest
86. Ribose transport protein RbsD [102545] (1)
  3 layers: a/b/a; mixed beta-sheet of 6 strands, order 251634; strand 6 is antiparallel to the rest
87. FabD/lysophospholipase-like [52150] (1)
  core: 3 layers, a/b/a; mixed beta-sheet of 6 strands, order 432156; strand 4 is antiparallel to the rest
88. L-sulfolactate dehydrogenase-like [89732] (1)
  core: 3 layers, a/b/a; mixed sheet of 7 strands, order 1237456; strands 1, 6 and 7 are antiparallel to the rest
89. Formyltransferase [53327] (1)
  3 layers: a/b/a; mixed beta-sheet of 7 strands, order 3214567; strand 6 is antiparallel to the rest
90. S-adenosyl-L-methionine-dependent methyltransferases [53334] (1)
  core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest
91. LmbE-like [102587] (1)
  3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest; topological similarity to SAM-dependent methyltransferases
92. PLP-dependent transferases [53382] (1)
  main domain: 3 layers: a/b/a, mixed beta-sheet of 7 strands, order 3245671; strand 7 is antiparallel to the rest
93. Nucleotide-diphospho-sugar transferases [53447] (1)
  3 layers: a/b/a; mixed beta-sheet of 7 strands, order 3214657; strand 6 is antiparallel to the rest
94. RibA-like [142694] (1)
  3 layers: a/b/a; mixed beta-sheet of 7 strands, order 1235467, strands 1 and 3 are antiparallel to the rest; partial topological similarity to some alpha/beta hydrolases (scop_cf 53473)
95. Activating enzymes of the ubiquitin-like proteins [69571] (1)
  3 layers: a/b/a; mixed beta-sheet of 8 strands, order 32145678; strands 6 and 8 are antiparallel to the rest
96. alpha/beta-Hydrolases [53473] (1)
  core: 3 layers, a/b/a; mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest
97. Nucleoside hydrolase [53589] (1)
  core: 3 layers, a/b/a ; mixed beta-sheet of 8 strands, order 32145687; strand 7 is antiparallel to the rest
98. Dihydrofolate reductase-like [53596] (1)
  3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
99. Ribokinase-like [53612] (3)
  core: 3 layers: a/b/a; mixed beta-sheet of 8 strands, order 21345678, strand 7 is antiparallel to the rest
  potential superfamily: members of this fold have similar functions but different ATP-binding sites
100. YjeF N-terminal domain-like [64152] (1)
  3 layers: a/b/a; mixed (mainly parallel) beta-sheet of 8 strands, order 32145678; strand 8 is antiparallel to the rest
101. Carbamate kinase-like [53632] (1)
  3 layers: a/b/a; mixed (mainly parallel) beta-sheet of 8 strands, order 34215786; strand 8 is antiparallel to the rest
102. 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain [64157] (1)
  core:3 layers: a/b/a; mixed beta-sheet of 8 strands, order 45321678, strands 4 and 5 are antiparallel to the rest
103. Alkaline phosphatase-like [53648] (1)
  core:3 layers: a/b/a; mixed beta-sheet of 8 strands, order 43516728, strand 7 is antiparallel to the rest
104. Hypothetical protein TT1679 [110709] (1)
  3 layers: a/b/a; mixed beta-sheet of 8 strands, order 78612354; strands 3, 4 and 8 are antiparallel to the rest
105. Glycerol-3-phosphate (1)-acyltransferase [69592] (1)
  3 layers: a/b/a; mixed beta-sheet of 9 strands, order 918736452; strands 1, 2 and 8 are antiparallel to the rest
106. AraD-like aldolase/epimerase [53638] (1)
  3 layers: a/b/a; mixed (mostly antiparallel) beta-sheet of 9 strands, order 432159876; left-handed crossover between strands 4 and 5
107. SurE-like [64166] (1)
  3 layers: a/b/a; mixed beta-sheet of 9 strands, order 342156798; strands 3, 8 and 9 are antiparallel to the rest; left-handed crossover connection between strands 6 and 7
108. Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1)
  consists of two intertwined (sub)domains related by pseudo dyad; duplication
  3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest
109. Amidase signature (AS) enzymes [75303] (1)
  possible duplication: the topologies of N- and C-terminal halves are similar; 3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213549A867 (A=10); strands from 5 to 9 are antiparallel to the rest
110. ATC-like [53670] (2)
  consists of two similar domains related by pseudo dyad; duplication
  core: 3 layers, a/b/a, parallel beta-sheet of 4 strands, order 2134
111. Tryptophan synthase beta subunit-like PLP-dependent enzymes [53685] (1)
  consists of two similar domains related by pseudo dyad; duplication
  core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 3214
112. SIS domain [53696] (1)
  3 layers: a/b/a; parallel beta-sheet of 5 strands, order 21345
113. Formate dehydrogenase/DMSO reductase, domains 1-3 [53705] (1)
  contains of two similar intertwined domains related by pseudo dyad; duplication
  core: 3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32451
114. ALDH-like [53719] (1)
  consists of two similar domains with 3 layers (a/b/a) each; duplication
  core: parallel beta-sheet of 5 strands, order 32145
115. NadA-like [142753] (1)
  duplication; consists of three similar domains related by pseudo threefold symmetry; 3 layers, a/b/a; parallel beta sheet, order: 2134
116. Aconitase iron-sulfur domain [53731] (1)
  consists of three similar domains with 3 layers (a/b/a) each; duplication
  core: parallel beta-sheet of 5 strands, order 32145
117. Phosphoglucomutase, first 3 domains [53737] (1)
  consists of three similar domains with 3 layers (a/b/a) each; duplication
  core: mixed beta-sheet of 4 strands, order 2134, strand 4 is antiparallel to the rest
118. FucI/AraA N-terminal and middle domains [53742] (1)
  consists of two domains of similar topology, 3 layers (a/b/a) each
  Domain 1 (1-173) has parallel beta-sheet of 5 strands, order 21345
  Domain 2 (174-355) has parallel beta-sheet of 4 strands, order 2134
119. YgbK-like [142763] (1)
  consists of two domains with partial topological similarity to the P-loop kinases but without the P-loop motif; the domain association results in the formation of a single mixed beta-sheet of 15 strands
120. Phosphoglycerate kinase [53747] (1)
  consists of two non-similar domains, 3 layers (a/b/a) each
  Domain 1 has parallel beta-sheet of 6 strands, order 342156
  Domain 2 has parallel beta-sheet of 6 strands, order 321456
121. UDP-Glycosyltransferase/glycogen phosphorylase [53755] (1)
  consists of two non-similar domains with 3 layers (a/b/a) each
  domain 1: parallel beta-sheet of 7 strands, order 3214567
  domain 2: parallel beta-sheet of 6 strands, order 321456
122. Glutaminase/Asparaginase [53773] (1)
  consists of two non-similar alpha/beta domains, 3 layers (a/b/a) each
  Domain 1 has mixed beta-sheet of 6 strands, order 213456, strand 6 is antiparallel to the rest; left-handed crossover connection between strands 4 and 5
  Domain 2 has parallel beta-sheet of 4 strands, order 1234
123. Phosphofructokinase [53783] (1)
  consists of two non-similar domains, 3 layers (a/b/a) each
  Domain 1 has mixed sheet of 7 strands, order 3214567; strands 3 & 7 are antiparallel to the rest
  Domain 2 has parallel sheet of 4 strands, order 2314
124. Tetrapyrrole methylase [53789] (1)
  consists of two non-similar domains
  Domain 1 has parallel sheet of 5 strands, order 32415
  Domain 2 has mixed sheet of 5 strands, order 12534; strands 4 & 5 are antiparallel to the rest
125. GckA/TtuD-like [82543] (1)
  consists of two non-similar domains
  Domain 1 has parallel sheet of 6 strands, order 321456, Rossmann-like topology
  Domain 2 has mixed sheet of 6 strands, order 126345; strands 5 and 6 are antiparallel to the rest; some similarity to CbiF Domain 2
126. DAK1/DegV-like [82548] (1)
  2 different domains; d1: [core: 3 layers, a/b/a; parallel sheet of 5 strands, order: 2134]; D2: [2 layers, a/b; mixed sheet of 6 strands, order 321645; strands 2 and 6 are antiparallel to the rest]
127. DHH phosphoesterases [64181] (1)
  consists of two non-similar domains
  Domain 1 has parallel sheet of 6 strands, order 321456
  Domain 2 has mixed sheet of 5 strands, order 12345; strands 1 & 4 are antiparallel to the rest
128. Glycerate kinase I [110737] (1)
  consists of two different alpha/beta domains; (1) of the Flavodoxin-like fold (scop_cf 52171); (2) similar to the Restriction endonuclease-like fold (scop_cf 52979), inserted into domain 1
129. PEP carboxykinase-like [53794] (1)
  contains a P-loop NTP-binding motif; mixed beta-sheet folds into a barrel-like structure with helices packed on one side
130. PEP carboxykinase N-terminal domain [68922] (1)
  contains mixed beta-sheets; topology is partly similar to that of the catalytic C-terminal domain
131. Chelatase-like [53799] (2)
  duplication: tandem repeat of two domains; 3 layers (a/b/a); parallel beta-sheet of 4 strands, order 2134
132. HemD-like [69617] (1)
  duplication: consists of two similar 'swapped' domain with 3 layers (a/b/a) each; parallel beta-sheet of 5 strands, order 21345
133. CAC2185-like [142794] (1)
  consists of two non-similar domains, 3 layers (a/b/a) each; d1 has parallel sheet of 4 strands, order 2134; d2 has parallel sheet of 5 strands, order 21345, and antiparallel meander sheet of 3 strands
134. Periplasmic binding protein-like I [53821] (1)
  consists of two similar intertwined domain with 3 layers (a/b/a) each: duplication
  parallel beta-sheet of 6 strands, order 213456
135. Periplasmic binding protein-like II [53849] (1)
  consists of two similar intertwined domain with 3 layers (a/b/a) each: duplication
  mixed beta-sheet of 5 strands, order 21354; strand 5 is antiparallel to the rest
136. Thiolase-like [53900] (1)
  consists of two similar domains related by pseudo dyad; duplication
  3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32451; strand 5 is antiparallel to the rest
137. NIF3 (NGG1p interacting factor 3)-like [102704] (1)
  consist of two intertwined domains; duplication: contains two structural repeats of alpha-beta-(beta-alpha)3 motif with mixed beta-sheet, order: 1432, strand 1 is antiparallel to the rest
138. Fe-only hydrogenase [53919] (1)
  consist of two intertwined domains; contains partial duplication
139. ComB-like [142822] (1)
  contains of two similar intertwined domains related by pseudo dyad; duplication; core: 3 layers: a/b/a; parallel beta-sheet of 4 strands, order 1423
140. CoA-transferase family III (CaiB/BaiF) [89795] (1)
  consist of two different alpha/beta domains; N-terminal domain has a SurE-like topology with a left-handed beta-alpha-beta unit
141. Cytidine deaminase-like [53926] (2)
  core: alpha-beta(2)-(alpha-beta)2; 3 layers (a/b/a); mixed beta-sheet of 4 strands, order 2134; strand 1 is antiparallel to the rest
Alpha and beta proteins (a+b) [53931] (334)
Mainly antiparallel beta sheets (segregated alpha and beta regions)
1. Microbial ribonucleases [53932] (1)
  single helix packs against antiparallel beta-sheet
2. Lysozyme-like [53954] (1)
  common alpha+beta motif for the active site region
3. Cysteine proteinases [54000] (1)
  consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn
4. His-Me finger endonucleases [54059] (1)
  core: (alpha)-beta-omega_loop-beta-alpha; embeded in larger different structures
5. RNase A-like [54075] (1)
  contains long curved beta-sheet and 3 helices
6. EndoU-like [142876] (1)
  comprises several helices and two three-stranded antiparallel beta-sheets; similar architecture to the RNase A-like fold (scop_cf 54075)
7. Prion-like [54097] (1)
  beta-alpha-beta-alpha(2); antiparallel beta-ribbon
8. LysM domain [54105] (1)
  beta-alpha(2)-beta; antiparallel strands
9. Head-to-tail joining protein W, gpW [64209] (1)
  alpha-beta(2)-alpha; antiparallel hairpin
10. Hypothetical protein MTH677 [110782] (1)
  alpha-beta(2)-alpha; 2 layers a/b; antiparallel beta-hairpin
11. GTF2I-like repeat [117772] (1)
  alpha(2)-beta-alpha-beta-alpha; 2 layers: a/b; antiparallel beta-ribbon
12. Urease, gamma-subunit [54110] (1)
  alpha(3)-beta(2); antiparallel hairpin
13. IL8-like [54116] (2)
  beta(3)-alpha
14. DNA-binding domain [54170] (1)
  beta(3)-alpha; 2 layers: alpha/beta
15. Penicillin-binding protein 2x (pbp-2x), c-terminal domain [54183] (1)
  alpha1-beta3; 2 layers: alpha/beta; order 132
16. Dodecin subunit-like [88797] (5)
  beta-alpha-beta(2); 2 layers: alpha/beta; antiparallel beta-sheet: order 132
17. Ribosomal proteins S24e, L23 and L15e [54188] (1)
  beta-(alpha)-beta-alpha-beta(2); 3 layers: alpha/beta/alpha; antiparallel beta-sheet: order 1243
18. Ribosome binding domain-like [100965] (2)
  beta-(2)-alpha(2)-beta(2); 2 layers: beta/alpha; antiparallel beta-sheet: order 1243; topological similarity to the common core of ribosomal proteins L23 and L15e
19. TFB5-like [142896] (1)
  beta-alpha-beta(2)-alpha; 2 layers, a/b; antiparallel sheet, order: 132; dimerises in solution (PDB 2jnj) via extended N-terminal strand
20. Obg GTP-binding protein C-terminal domain [102740] (1)
  beta-(2)-alpha(3)-beta(2); 2 layers: beta/alpha; mixed beta-sheet: order 1234; strands 2 and 3 a parallel to each other
21. HIT-like [54196] (2)
  alpha-beta(3)-alpha-beta(2); 3 layers: alpha/beta/alpha
22. Secretion chaperone-like [69634] (3)
  alpha-beta(3)-alpha-beta(2)-alpha; 2 layers: alpha/beta
23. DNA-binding domain of intron-encoded endonucleases [64495] (1)
  beta(2)-alpha(2)-beta; 2 layers; 3-stranded antiparallel beta-sheet, order 213; HTH motif; also includes the extra N-terminal, DNA minor groove-binding helix
24. MotA C-terminal domain-like [69651] (1)
  alpha-beta(4)-alpha-beta(2)-alpha; 2 layers: alpha/beta
25. YktB/PF0168-like [142912] (1)
  alpha-beta(4)-alpha-beta(2)-alpha-beta-alpha; 2 layers, a/b; antiparallel beta-sheet, order: 1234756; half-barrel shape; topological similarity to the MotA C-terminal domain-like fold (scop_cf 69651) and the Secretion chaperone-like fold (scop_cf 69634)
26. Mago nashi protein [89816] (1)
  beta(4)-alpha-beta(2)-alpha; 2 layers: alpha/beta; antiparallel beta-sheet, order: 651234
27. WGR domain-like [142920] (1)
  beta(4)-alpha-X-beta; 2 layers, a/b; antiparallel beta-sheet, order 51234; the beta-hairpin insetrion in strand 1 results in the formation of a beta-triangle structure
28. Ribosomal protein S5 domain 2-like [54210] (1)
  core: beta(3)-alpha-beta-alpha; 2 layers: alpha/beta; left-handed crossover
29. beta-Grasp (ubiquitin-like) [54235] (13)
  core: beta(2)-alpha-beta(2); mixed beta-sheet 2143
30. WWE domain [117838] (1)
  beta(2)-alpha-beta(4); antiparallel folded beta-sheet (half-barrel), order 216543
31. FAD-linked reductases, C-terminal domain [54372] (1)
  alpha+beta sandwich
32. Cystatin-like [54402] (7)
  Core: alpha-beta(4); helix packs against coiled antiparallel beta-sheet
33. Nuclease A inhibitor (NuiA) [82601] (1)
  alpha-beta-alpha-beta-alpha(2)-beta(3); antiparallel beta-sheet; order: 15432
34. Colicin D/E5 nuclease domain [102823] (1)
  alpha(2)-beta(4)-alpha, 2 layers: alpha/beta, antiparallel beta sheet, meander
35. RelE-like [143010] (1)
  beta-alpha(2)-beta(4), 2 layers; a/b, antiparallel beta-sheet; order 15432
36. Hypothetical protein SAV1430 [110835] (1)
  beta(3)-alpha-beta(2)-alpha; 2 layers, alpha/beta; antiparallel beta-sheet, order: 12543
37. Ns1 effector domain-like [143020] (1)
  beta-X-beta(5)-alpha-beta-alpha; 2 layers: a/b; bifurcated beta-sheet; order 23654[1,7]
38. YbaB-like [82606] (1)
  core: alpha-beta(3)-alpha, 2 layers:alpha/beta, three-stranded antiparallel beta sheet, strand order 123
39. Kinetochore globular domain-like [143025] (1)
  core: alpha-beta(3)-alpha; variant: alpha-beta(4)-alpha(2)
40. L35p-like [143033] (1)
  core: alpha-beta(3)-alpha; 2layers a/b
41. Cell division protein ZapA-like [102828] (1)
  core: beta(2)-alpha(2), 2 layers: alpha/beta; long C-terminal helix forms dimeric parallel and tetrameric antiparallel coiled coils
42. ssDNA-binding transcriptional regulator domain [54446] (1)
  helix-swapped dimer of beta(4)-alpha motifs
43. Photosystem I subunit PsaD [64233] (1)
  beta-BETA(2)-beta-alpha-beta(2); antiparallel sheet: order 2134 packed against helix and BETA-hairpin on the same side; irregular C-terminal tail
44. MHC antigen-recognition domain [54451] (1)
  dimeric
45. UBC-like [54494] (1)
  alpha-beta(4)-alpha(3); core: meander beta-sheet plus one helix 2
46. SAND domain-like [63762] (1)
  core: three short helices packed against a barrel-like beta-sheet; some similarity to the SH3-like fold
47. Coronavirus NSP8-like [143075] (1)
  core: alpha-beta(2)-alpha-beta(4)-alpha-beta; bifurcated barrel-like beta-sheet
48. ParB/Sulfiredoxin [110848] (1)
  beta*-alpha-beta(2)-alpha-beta-alpha; mixed beta sheet forms a partly open barrel: (n*=4, S*=8)
49. BtrG-like [110856] (1)
  beta-alpha-beta(4)-alpha-beta(2); contains beta-sheet barrel (n=5, S=8)
50. BB1717-like [143080] (1)
  complex fold with a bifurcated beta-sheet structure surrounded by helices; contains beta-sheet barrel, closed (n=5, S=8)
51. AF0104/ALDC/Ptd012-like [117855] (1)
  duplication: consists of two similar beta-alpha-beta(4) motifs
52. NSFL1 (p97 ATPase) cofactor p47, SEP domain [102847] (1)
  beta(3)-alpha(2)-beta; 2 layers; mixed beta-sheet, order 4123, strands 1 and 4 are parallel to each other
53. TTHA1013-like [143099] (1)
  beta(3)-alpha-beta; 2 layers; mixed beta-sheet, order 4123, strands 1 and 4 are parallel to each other; topological similarity to the SEP domain fold (scop_cf 102847); dimerises via the long C-terminal strand with the formation of a single beta-sheet
54. Diaminopimelate epimerase-like [54505] (1)
  mixed beta-sheet folds into a barrel (n=8, S=14) around the central helix
55. GFP-like [54510] (1)
  beta-sheet folds into a barrel (n=11, S=14) around the central helix
56. Tubby C-terminal domain-like [54517] (1)
  beta-sheet folds into a barrel (n=12, S=12) around the central helix
57. Pili subunits [54522] (1)
  contains very long N-terminal helix, which end is packed against beta-sheet
58. Mitochondrial glycoprotein MAM33-like [54528] (1)
  core: beta(7)-alpha(2); N- and C-terminal extensions form a coiled coil subdomain
59. NAP-like [143112] (1)
  core: central meander 4-stranded beta-sheet (order: 1234) transversed by a C-terminal helix
60. Polo-box domain [82614] (1)
  beta(6)-alpha; antiparallel beta-sheet, meander
61. mRNA decapping enzyme DcpS N-terminal domain [102859] (1)
  beta(3)-alpha-beta(3)-alpha; 3 layers a/b/a
62. Inhibitor of vertebrate lysozyme, Ivy [89871] (1)
  alpha(2)-beta(5)-alpha(2); 3 layers a/b/a; meander beta-sheet
63. FKBP-like [54533] (3)
  core: beta(2)-alpha-beta(2); antiparallel beta-sheet
64. Ribosomal protein S16 [54564] (1)
  beta(4)-alpha-beta; 2 layers: alpha/beta; mixed beta-sheet, order: 51234
65. Ribosomal protein S19 [54569] (1)
  alpha-beta-X-beta(2); 2 layers: alpha/beta; mixed beta-sheet, order: 123
66. YefM-like [143119] (1)
  core: beta-alpha(2)-beta(2)-alpha; mixed beta-sheet, order:123, strands 1 and 2 are parallel; forms compact dimer with a single beta-sheet;
67. Ribosomal protein L31e [54574] (1)
  beta-alpha-beta-(alpha)-beta(2); 2 layers: alpha/beta; mixed beta-sheet, order: 1342
68. Allophycocyanin linker chain (domain) [54579] (1)
  beta(2)-alpha-beta; 2 layers: alpha/beta
69. Cdc48 domain 2-like [54584] (1)
  beta-alpha-beta(3); 2 layers: alpha/beta
70. Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [54592] (1)
  beta-alpha-beta(3); 2 layers: alpha/beta
71. Chromosomal protein MC1 [102874] (1)
  beta(2)-alpha-beta(3); 2 layers: alpha/beta
72. beta-hairpin-alpha-hairpin repeat [74651] (2)
  multiple repeats of beta(2)-alpha(2) motif
73. Proguanylin [89889] (1)
  beta(2)-alpha(3)-beta; two layers: alpha/beta; antiparallel sheet: order 213
74. Bacterial protein-export protein SecB [54610] (1)
  beta(4)-alpha(2); two layers: alpha/beta; antiparallel sheet: order 1432
75. MesJ substrate recognition domain-like [82828] (1)
  beta-alpha(2)-beta(3); 2 layers: a/b; antiparallel beta-sheet, order:1432
76. FYSH domain [89894] (1)
  beta(2)-alpha(2)-beta(2)-alpha-beta; two layers: alpha/beta; antiparallel sheet: order 51234
77. VSV matrix protein [75403] (1)
  beta-alpha(2)-beta(4)-alpha-beta(2); two layers: alpha/beta; bifurcated coiled beta-sheet: order of the first 5 strands: 23154
78. DNA-binding domain of Mlu1-box binding protein MBP1 [54615] (1)
  beta(4)-alpha(2)-beta(2)-alpha; antiparallel sheet: order 123465
79. Heme-binding protein A (HasA) [54620] (1)
  beta-alpha-beta(6)-alpha(2); antiparallel sheet: order 165432
80. Chalcone isomerase [54625] (1)
  beta(3)-alpha(2)-beta-alpha(2)-beta3; 2 layers alpha/beta; antiparallel sheet: order 1234567
81. Coproporphyrinogen III oxidase [102885] (1)
  alpha-beta(6)-alpha(2)-beta-alpha(n); 3 layers alpha/beta/alpha; antiparallel sheet: order 1234567
82. Hypothetical protein Ta1206 [102890] (1)
  beta(4)-alpha-beta(2)-alpha(2); mixed, predominately antiparallel beta-sheet, order: 123465, strands 4 and 5 are parallel to each other
83. CBS-domain [54630] (1)
  core: beta-alpha-beta(4); 2 layers: alpha/beta
84. Thioesterase/thiol ester dehydrase-isomerase [54636] (1)
  core: beta-alpha-beta(4); 2 layers: alpha/beta
85. DLC [54647] (1)
  core: beta-alpha(2)-beta-X-beta(2); 2 layers: alpha/beta; antiparallel beta-sheet: order 1342
86. CI-2 family of serine protease inhibitors [54653] (1)
  alpha+beta sandwich; loop across free side of beta-sheet
87. Integrin beta tail domain [69686] (1)
  alpha-beta-loop-beta(3); loop across free side of beta-sheet
88. alpha/beta-Hammerhead [54664] (5)
  core: beta-BETA-alpha-beta-BETA-beta-alpha; contains a beta-hammerhead motif similar to that in barrel-sandwich hybrids
89. POZ domain [54694] (1)
  core: beta(2)-alpha(2)-beta(2)-alpha(2); 2 layers a/b; mixed sheet: 2143
90. EF-Ts domain-like [54712] (2)
  beta(2)-alpha(n)-beta; 2 layers a/b; antiparallel sheet: 123
91. Fe,Mn superoxide dismutase (SOD), C-terminal domain [54718] (1)
  alpha-beta(2)-alpha-beta-alpha(2); 3 strands of antiparallel sheet: 213
92. ClpS-like [54735] (1)
  beta-alpha(2)-beta-alpha-beta; 2 layers, alpha/beta
93. Hypothetical protein MTH1880 [75411] (1)
  beta-alpha-beta(2)-alpha(2); 3 layers, alpha/beta/alpha; antiparallel beta-sheet: order 123
94. Ribosomal L11/L12e N-terminal domain [54746] (1)
  beta-alpha(2)-beta(2); 2 layers, alpha/beta; antiparallel beta-sheet: order 123
95. Anti-LPS factor/recA domain [54751] (2)
  alpha-beta(3)-alpha(2); 2 layers, alpha/beta
96. Signal recognition particle alu RNA binding heterodimer, SRP9/14 [54761] (1)
  (beta)-alpha-beta(3)-alpha; 2 layers, alpha/beta
97. dsRBD-like [54767] (5)
  alpha-beta(3)-alpha; 2 layers: alpha/beta
98. 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain [110920] (1)
  duplication: consists of two beta(3)-alpha repeats; 3 layers, beta/alpha/beta
99. SRP19 [69694] (1)
  beta-alpha-beta(2)-alpha; 2 layers: alpha/beta
100. SufE/NifU [82648] (1)
  alpha(2)-beta(3)-alpha(3); 2 layers alpha/beta, 3-stranded antiparallel beta-sheet; order 123
101. DNA-binding protein Tfx [89914] (1)
  alpha(3)-beta-alpha(2)-beta(2); 2 layers alpha/beta, 3-stranded antiparallel beta-sheet; order 123
102. Eukaryotic type KH-domain (KH-domain type I) [54790] (1)
  beta-alpha(2)-beta(2)-alpha; 2 layers: alpha/beta
103. Alpha-lytic protease prodomain-like [54805] (8)
  core: alpha-beta(2)-(alpha)-beta; 2 layers: alpha/beta
104. Nucleotidyltransferase [81302] (1)
  core: alpha-beta-turn-beta-X-beta-(alpha); mixed beta-sheet, order of core strands: 123
105. Nqo5-like [143242] (1)
  core: alpha-beta(2)-alpha-beta(3); 2 layers, a/b; mixed beta-sheet, order 12534, strands 2 and 5 are parallel
106. Ribosomal protein S3 C-terminal domain [54820] (1)
  alpha(2)-beta(4); 2 layers: alpha/beta; antiparallel beta-sheet: order 2143
107. Transcription factor NusA, N-terminal domain [69704] (1)
  alpha-beta(3)-alpha-beta-alpha; bifurcated coiled beta-sheet
108. Enolase N-terminal domain-like [54825] (1)
  beta(3)-alpha(3); meander and up-and-down bundle
109. Ribosomal protein L22 [54842] (1)
  beta-alpha(3)-beta(2); 2 layers: alpha/beta; related to the enolase/MLE N-domain fold by a circular permutation
110. Prokaryotic ribosomal protein L17 [64262] (1)
  alpha-beta-alpha(3)-beta(2); 2 layers: alpha/beta;
111. GroEL-intermediate domain like [54848] (1)
  3-helical bundle packed against 3-stranded mixed beta-sheet
112. PX domain [64267] (1)
  beta(3)-alpha(4); meander beta-sheet packed against array of helices; contains Pro-rich stretch
113. DsrC, the gamma subunit of dissimilatory sulfite reductase [69720] (1)
  beta(3)-alpha(5); meander beta-sheet packed against array of helices
114. DNA damage-inducible protein DinI [54856] (1)
  beta-alpha-beta(2)-alpha; 2 layers: alpha/beta; mixed sheet 213; crossing loops
115. HSP90 C-terminal domain [110941] (1)
  alpha-beta(3)-alpha(3); 2 layers, a/b; mixed beta-sheet, order:132; crossing loops
116. Ferredoxin-like [54861] (55)
  alpha+beta sandwich with antiparallel beta-sheet; (beta-alpha-beta)x2
117. PurS-like [109622] (1)
  consists of two alpha+beta subdomains with some similarity to the ferredoxin-like fold
118. Dystroglycan, domain 2 [111005] (1)
  beta-alpha-beta-X-beta(2)-alpha(2)-beta; antiparallel beta-sheet, order 24153; topological similarity to the ferredoxin-like fold (scop_cf 54861)
119. Pseudouridine synthase [100877] (1)
  consists of two alpha+beta subdomains with some similarity to the ferredoxin-like fold
120. Folate-binding domain [103024] (1)
  duplication: consists of two beta(2)-alpha-beta(3)-alpha subdomains swapped with the first strands
121. THUMP domain [143436] (1)
  contains mixed 8-stranded beta-sheet, folded into a half-barrel and covered with 4 helices on the outside; order 32148756; strands 5, 6 and 7 are parallel
122. AMMECR1-like [143446] (1)
  duplication; contains two beta(2)-alpha-beta(2) structural repeats, swapped with C-terminal strands; extra N-terminal helix and C-terminal strand
123. YehU-like [118000] (1)
  beta-alpha(2)-beta(2)-alpha; 3 layers, alpha/beta/alpha; antiparallel beta-sheet: order 123
124. Hypothetical protein YwqG [103031] (1)
  duplication: contains two similar beta-x-beta(4) motifs swapped with the first strands
125. VC0467-like [143455] (1)
  complex fold; contains bifurcated beta-sheet structure folded into pseudo barrel
126. Lesion bypass DNA polymerase (Y-family), little finger domain [100878] (1)
  beta-alpha-beta(2)-alpha-beta; antiparallel beta-sheet: order 1423; "reversed" ferredoxin-like topology
127. ImmE5-like [143468] (1)
  alpha-beta(2)-alpha-beta; 2 layers, a/b; antiparallel beta-sheet, order 213
128. Ribosomal protein L30p/L7e [55128] (1)
  core: beta-alpha-beta-alpha-beta; antiparallel beta-sheet: order 312; some similarity to the ferredoxin-like fold
129. Chorismate lyase-like [64287] (1)
  duplication of alpha(2)-beta(3) motif; antiparallel beta sheet, order 123654
130. TM1622-like [143476] (1)
  alpha-beta(3)-alpha-beta(4)-alpha; 3 layers, a/b/a; antiparallel beta-sheet, order: 1237654
131. Probable bacterial effector-binding domain [55135] (1)
  duplication of beta-alpha-beta(2) motif: antiparallel beta sheet forms barrel (n=6, S=12)
132. CheC-like [103038] (1)
  duplication: tandem repeat of two intertwined alpha-beta-(X)-beta(2) motifs
133. LigT-like [55143] (1)
  duplication of beta-alpha-beta-alpha-beta motif: antiparallel beta sheet forms barrel (n=6, S=8) similar to the barrel of prokaryotic DNA topoisomerases I and III
134. Pepsin inhibitor-3 [55148] (1)
  duplication of beta(3)-alpha(2) motif: meander beta sheets form barrel-like structure
135. CYTH-like phosphatases [55153] (1)
  duplication of beta-alpha-beta(3) motif: antiparallel beta sheet forms wide barrel (n=8, S=16) with a channel running through it
136. Antiparallel beta/alpha barrel (PT-barrel) [143491] (1)
  tandem repeat of five alpha(2)-beta(2) motifs; antiparallel beta-sheet barrel, closed; n=10, S=10; order 123456789A; there is a channel along the barrel axis
137. eIF1-like [55158] (2)
  beta(2)-alpha-beta(2)-alpha-beta; 2 layers: alpha/beta; mixed beta-sheet: order 51243
138. Hedgehog/DD-peptidase [55165] (1)
  alpha-beta(2)-alpha-beta(2); 2 layers: alpha/beta
139. Alpha-L RNA-binding motif [55173] (1)
  alpha(2)-beta(2)-loop-beta; 2 layers: alpha/beta
140. RRF/tRNA synthetase additional domain-like [55185] (4)
  core: alpha-beta(2)-alpha-beta(2); 2 layers: alpha/beta
141. LuxS/MPP-like metallohydrolase [63410] (1)
  core: beta-alpha-beta(2)-alpha(2); 2 layers: alpha/beta
142. IF3-like [55199] (7)
  beta-alpha-beta-alpha-beta(2); 2 layers; mixed sheet 1243, strand 4 is antiparallel to the rest
143. PUG domain-like [143502] (1)
  alpha(2)-beta-alpha(2)-beta(2)-alpha; cluster of helices with a small antiparallel beta-sheet on one side; order 132; topological similarity to the fold of an extended R3H domain (PDB 1whr)
144. Ribosome binding protein Y (YfiA homologue) [69753] (1)
  beta-alpha-beta(3)-alpha; 2 layers; mixed sheet 1234, strand 3 is antiparallel to the rest
145. TolA/TonB C-terminal domain [74652] (1)
  beta(2)-alpha-beta; 2 layers, alpha/beta; left-handed beta-alpha-beta unit in non-swapped monomer
146. Yeast killer toxins [55220] (1)
  beta-alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta; left-handed crossover connection
147. Cell division protein MinE topological specificity domain [55228] (1)
  dimer of alpha-beta(2) motifs ; 2 layers, alpha/beta
148. Hypothetical protein YoaG [103062] (1)
  dimer of beta(2)-alpha motifs ; 2 layers, alpha/beta; reverse MinE topology
149. Nucleocapsid protein dimerization domain [103067] (1)
  dimer of alpha-beta(2)-alpha motifs ; 2 layers, alpha/beta
150. Cyanase C-terminal domain [55233] (1)
  intertwined dimer of alpha-beta(2) motifs ; 2 layers, alpha/beta
151. Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains [82713] (1)
  Intertwined pseudo hexamer of an alpha+beta motif
152. RuBisCO, small subunit [55238] (1)
  alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta
153. DCoH-like [55247] (4)
  beta(2)-alpha-beta(2)-alpha; 2 layers, alpha/beta
154. TRCF domain-like [143516] (1)
  beta-alpha(3)-beta(2)-alpha-beta(2)-alpha; 2 layers: alpha/beta; mixed beta sheet, order 12354, strands 1 and 2 are parallel; some topological similarity to the DCoH-like fold (scop_cf 55247)
155. Hypothetical protein Yml108w [100886] (1)
  beta(2)-alpha-beta(2)-alpha; 2 layers, alpha/beta; mixed beta-sheet 2143, strands 1 and 4 are parallel
156. MutS N-terminal domain-like [55266] (2)
  beta(2)-alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta
157. GYF domain [55276] (1)
  beta(2)-alpha-beta(2)-alpha; 2 layers, alpha/beta
158. GTP cyclohydrolase I feedback regulatory protein, GFRP [69760] (1)
  beta(2)-alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta, antiparallel beta-sheet: order 342165
159. Ribosomal protein L5 [55281] (1)
  beta-alpha-beta(2)-alpha-beta(3)-alpha; 2 layers, alpha/beta; antiparallel beta-sheet: order 231654
160. RPB5-like RNA polymerase subunit [55286] (1)
  core: beta-alpha-beta-alpha-beta(2); 2 layers, alpha/beta
161. Bacillus chorismate mutase-like [55297] (7)
  core: beta-alpha-beta-alpha-beta(2); mixed beta-sheet: order: 1423, strand 4 is antiparallel to the rest
162. YjbQ-like [111037] (1)
  beta(2)-alpha-beta(2)-alpha(2)-beta(3); contains a beta-sandwich: 7 strands in 2 sheets; trimerizes with orthogonally packed beta-sheets
163. Tautomerase/MIF [55330] (1)
  (beta-alpha-beta)2; 2 layers: alpha/beta; mixed beta-sheet
  generally forms trimers with three closely packed beta-sheets
164. FwdE/GAPDH domain-like [55346] (3)
  core: alpha-beta-alpha-beta(3); mixed sheet: 2134, strand 2 is parallel to strand 1
165. Hypothetical protein PF0899 [111056] (1)
  alpha-beta-alpha-beta(4); 2 layers: a/b; mixed beta-sheet, order 23145, strands 1 and 3 are parallel; similar to the GAPDH C-terminal domain-like fold (scop_cf 55346)
166. Major capsid protein gp5 [56562] (1)
  unusual fold; contains PF0899-like core, decorated with additional structure
167. MK0786-like [143559] (1)
  alpha(2)-beta(4); 2 layers: a/b; antiparallel beta-sheet, order 1234 (meander)
168. YkuJ-like [143566] (1)
  alpha-beta(4)-alpha; 2 layers a/b; antiparallel beta-sheet, order 1234
169. N domain of copper amine oxidase-like [55382] (5)
  alpha-beta(5)-alpha; 2 layers: alpha/beta; meander antiparallel sheet
170. Aha1/BPI domain-like [55393] (2)
  core: [beta]-alpha-beta(5)-alpha; 2 layers: alpha/beta; antiparallel beta-sheet, meander
171. Subtilisin inhibitor [55398] (1)
  alpha+beta sandwich
172. RNA bacteriophage capsid protein [55404] (1)
  6-standed beta-sheet followed with 2 helices; meander
173. eIF4e-like [55417] (1)
  beta(2)-alpha-beta(2)-alpha-beta(2)-alpha-beta-2; 2 layers: alpha/beta; antiparallel sheet: 21356478
174. CO dehydrogenase flavoprotein C-domain-like [55423] (2)
  core: beta(3,4)-alpha(3); alpha+beta sandwich
175. SRF-like [55454] (1)
  alpha-beta(2)-alpha; dimer; 3 layers a/b/a; antiparallel beta-sheet
176. Origin of replication-binding domain, RBD-like [55463] (1)
  alpha-beta-alpha-beta(2)-alpha-beta-alpha-beta; 3 layers: a/b/a; antiparallel sheet 41325
177. SARS receptor-binding domain-like [143586] (1)
  core: 3 layers, a/b/a; antiparallel beta-sheet of 5 strands, order 13542
178. Hut operon positive regulatory protein HutP [111063] (1)
  alpha(2)-beta-alpha(2)-beta(3); 3 layers: a/b/a; antiparallel beta-sheet: order 1234
179. Hypothetical protein yfbM [111068] (1)
  beta-alpha(2)-beta-alpha(2)-beta(2)-alpha(n)-beta; 3 layers: a/b/a; antiparallel beta-sheet, order: 21543
180. TTHA1528-like [143591] (1)
  beta-alpha-beta(3)-alpha-beta-alpha(2)-beta; 3 layers: a/b/a; mixed beta-sheet, order: 143256, parallel strands' pairs are 1-4 and 2-5
181. YojJ-like [143596] (1)
  alpha-beta-X-beta-alpha-beta(2)-alpha-beta(3); 3 layers: a/b/a; 7-stranded mixed beta-sheet, order 2431567; strands 1 and 3 are parallel to each other
182. STIV B116-like [143601] (1)
  subunit fold consists of mixed 5-stranded beta-sheet, order:31452, strand 5 is antiparallel to the rest, with 3 helices on one side; dimerises with the formation of a single 10-stranded beta-sheet; strand 2 is in the dimer interface
183. Bacillus phage protein [111073] (1)
  alpa-beta(3)-alpha-beta(3)-alpha; 3 layers: b/a/b, 3-helical bundle flanked by two 3-stranded meander beta-sheets
184. FMN-dependent nitroreductase-like [55468] (1)
  core: (alpha-beta-alpha-beta)2; 3 layers a/b/a; antiparallel beta-sheet: 1243
185. N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 [55480] (1)
  alpha-beta-alpha(2)-beta(3)-alpha; 3 layers a/b/a; antiparallel beta-sheet: 4123
186. Zincin-like [55485] (2)
  contains mixed beta sheet with connection over free side of the sheet
187. SH2-like [55549] (1)
  3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flaked by two helices
188. HPr-like [55593] (2)
  beta-alpha-beta(2)-alpha-beta-alpha; 2 layers: a/b; antiparallel sheet 1423
189. TrkA C-terminal domain-like [116725] (1)
  beta-X-beta(2)-X-beta-alpha; pseudo barrel capped by helix at one end; topological similarity to the HPr-like fold
190. Hypothetical protein YjiA, C-terminal domain [90001] (1)
  beta-alpha-beta(4)-alpha; 2 layers: a/b; antiparallel sheet 15234; topological similarity to the HPr-like fold
191. YggU-like [69785] (1)
  beta(2)-loop-alpha-beta(2)-alpha; 2 layers: a/b; antiparallel sheet 1243; some similarity to the Homing endonuclease-like fold
192. Homing endonuclease-like [55603] (2)
  alpha-beta(2)-alpha-beta(2)-alpha; 2 layers: a/b; antiparallel sheet 1243
193. T-fold [55619] (2)
  beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1234
  tunnel-shaped: its known members form wide oligomeric barrels different sizes
194. Cell cycle regulatory proteins [55636] (1)
  beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1243
  can form strand-exchange dimers
195. beta-lactamase-inhibitor protein, BLIP [55647] (1)
  alpha(2)-beta(4); 2 layers: alpha/beta
196. Ribosomal protein L9 C-domain [55652] (1)
  alpha-beta-alpha(2)-beta(2); 2 layers: alpha/beta
197. L9 N-domain-like [55657] (1)
  beta(2)-alpha-beta-alpha; 3 layers: alpha/beta/alpha
198. Tombusvirus P19 core protein, VP19 [103144] (1)
  beta(2)-alpha-beta(2)-alpha; 2 layers: alpha/beta; antiparallel sheet: order 2134
199. Ribonuclease PH domain 2-like [55665] (1)
  beta(2)-alpha-beta(2)-alpha; 3 layers: alpha/beta/alpha; antiparallel sheet: order 2134
200. Regulatory factor Nef [55670] (1)
  alpha(2)-beta(4)-alpha; 3 layers: alpha/beta/alpha
201. CytB endotoxin-like [55675] (1)
  core: beta-alpha(2)-beta-alpha(2)-beta(4); 3 layers: a/b/a
202. Class II aaRS and biotin synthetases [55680] (1)
  contains large mixed beta-sheet
203. Subdomain of clathrin and coatomer appendage domain [55710] (1)
  beta-alpha-beta-alpha-beta(4)-alpha; 3 layers: a/b/a; bifurcated antiparallel beta-sheet
204. Sterol carrier protein, SCP [55717] (1)
  alpha-beta(3)-(crossover)-beta-(alpha)-beta; 3 layers: a/b/a; antiparallel beta-sheet of 5 strands; order: 32145
205. Ta1353-like [103164] (1)
  core: beta-alpha-beta(2)-alpha-beta-alpha-beta; 3 layers: a/b/a; antiparallel beta-sheet of 5 strands; order: 51423;
206. Mog1p/PsbP-like [55723] (1)
  (beta-hairpin)-beta(3)-alpha-beta(4)-alpha; 3 layers: a/b/a; antiparallel beta-sheet of 7 strands; order: 1237654
207. Acyl-CoA N-acyltransferases (Nat) [55728] (1)
  3 layers: a/b/a; contains mixed beta-sheet
208. Gelsolin-like [55752] (2)
  3 layers: a/b/a; contains mixed beta-sheet
209. PHP14-like [143723] (1)
  beta(3)-alpha-beta(2)-alpha-beta; 3 layers, a/b/a; mixed beta-sheet, half-barrel, order: 132456; strands 2 and 5 are antiparallel to the rest
210. Profilin-like [55769] (9)
  core: 2 alpha-helices and 5-stranded antiparallel sheet: order 21543; 3 layers: alpha/beta/alpha
211. Ligand-binding domain in the NO signalling and Golgi transport [111125] (1)
  an N-terminal helical bundle and the C-terminal alpha-beta(2)-alpha-beta(2) subdomain enclose a ligand-binding cavity
212. Phage tail protein-like [143748] (1)
  alpha-beta-X-beta(2)-alpha-beta(2); 2 layers: a/b; mixed beta-sheet: order 12354, strands 1 and 2 are parallel
213. PR-1-like [55796] (1)
  alpha-beta-alpha-beta-alpha(2)-beta(2); 3 layers, alpha/beta/alpha; mixed sheet: order 1342
214. Phoshotransferase/anion transport protein [55803] (1)
  beta-alpha(2)-beta(3)-alpha(3); 3 layers, alpha/beta/alpha; mixed sheet: order 1342; loop crossing
215. Nudix [55810] (1)
  beta(2)-alpha-beta(3)-alpha; 3 layers: alpha/beta/alpha; mixed sheet
  contains beta-grasp motif
216. 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain [55815] (1)
  core: alpha-beta(2)-alpha-beta(2)-alpha-beta; 3 layers; mixed sheet: order 31425
217. YrdC/RibB [55820] (1)
  core: alpha-beta(2)-alpha-beta-alpha(2)-beta(2)-alpha-beta-alpha-beta; 3 layers; mixed twisted sheet of 7 strands; order 7126354; strands 7 and 1 are parallel to each other
218. GIY-YIG endonuclease [82770] (1)
  beta(2)-alpha(2)-beta-alpha-(beta); strand 4 is very short; 3 layers; antiparallel (mixed) beta-sheet; order 312(4)
219. YbaK/ProRS associated domain [55825] (1)
  core: alpha-beta-alpha-beta(2)-(alpha-beta)2-alpha-beta(2)-alpha-beta; 3 layers; bifurcated mixed sheet
220. Thymidylate synthase/dCMP hydroxymethylase [55830] (1)
  contains large mixed beta-sheet
221. Thymidylate synthase-complementing protein Thy1 [69795] (1)
  complex alpha+beta fold; contains antiparallel 5-stranded beta-sheet: order 12354
222. N-acetylmuramoyl-L-alanine amidase-like [55845] (1)
  contains mixed beta-sheet
223. Cytochrome b5-like heme/steroid binding domain [55855] (1)
  beta-alpha-beta(2)-alpha(1,2)-(beta)-alpha(2)-beta; 3 layers: a/b/a; antiparallel beta-sheet, order: 1532(4)
224. DUSP-like [143790] (1)
  alpha-beta-alpha-X-beta-alpha-beta; three-helical bundle capped at one end by antiparallel beta-sheet, order: 213
225. DNA topoisomerase I domain [55868] (1)
  beta(2)-alpha-beta-(alpha)-beta(2); left-handed crossover between strands 2 & 3
226. ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873] (1)
  8-stranded mixed beta-sheet; 2 layers: alpha/beta
227. Sporulation response regulatory protein Spo0B [55889] (1)
  core: alpha-beta-alpha-beta(2)-(alpha)-beta(2)
228. Ribonuclease Rh-like [55894] (1)
  alpha+beta fold
229. YlxR-like [64375] (1)
  alpha+beta fold; could have evolved from a glucocorticoid receptor-like zinc finger domain
230. YggX-like [111147] (1)
  beta(2)-alpha(3); contains zinc-less 'zinc finger'-like fold (scop_cf 57715; see also scop_cf 64375)
231. L28p-like [143799] (1)
  unusual fold consisting of three beta-hairpins, that form a paper clip-like structure, and two helices; could have evolved from a glucocorticoid receptor-like zinc finger domain (scop_cf 57715)
232. Ornithine decarboxylase C-terminal domain [55903] (1)
  complex alpha+beta motif
233. Pentein, beta/alpha-propeller [55908] (1)
  duplication: composed of 5 alpha-beta(2)-alpha-beta units arranged around pseudo fivefold axis
234. Creatinase/aminopeptidase [55919] (1)
  duplication: composed of two very similar alpha+beta folds
235. Glutamine synthetase/guanido kinase [55930] (1)
  duplication: common core consists of two beta-alpha-beta2-alpha repeats
236. TBP-like [55944] (10)
  beta-alpha-beta(4)-alpha
237. XisI-like [143846] (1)
  alpha-beta(4)-alpha-beta-alpha; 2 layers, a/b; antiparallel beta-sheet, order 1234, meander; the open side of beta-sheet provides dimerization interface
238. S-adenosylmethionine synthetase [55972] (1)
  duplication: consists of 3 similar intertwined domains
  structural repeat: beta-alpha-beta(2)-alpha-beta; two layers, alpha/beta
239. DNA clamp [55978] (1)
  contains two helices and two beta sheets
  duplication: fold has internal pseudo two-fold symmetry
240. Hypothetical protein TM0160 [103255] (1)
  duplication: consists of two beta(3)-alpha(2) structural repeats; single barrel-like beta-sheet
241. Molybdenum cofactor-binding domain [56002] (1)
  beta(2)-alpha-beta-alpha-beta; 2 layers: a/b; mixed sheet: order 1243: crossing loops
242. Sulfite reductase hemoprotein (SiRHP), domains 2 and 4 [56013] (1)
  beta-alpha-beta-alpha-beta(3)-alpha(2,3); mixed sheet: order 12345; left-handed crossover connection between strands 1 and 2
243. DeoB insert domain-like [143855] (1)
  alpha-beta-X-beta(2)-alpha-beta(2); 2 layers, a/b; mixed beta-sheet of 5 strands, order 12345; strands 2 and 5 are antiparallel to the rest
244. The spindle assembly checkpoint protein mad2 [56018] (1)
  core: alpha(2)-beta(2)-alpha-beta; mixed sheet: order 213
245. Phospholipase D/nuclease [56023] (1)
  beta-alpha-beta-alpha-beta-alpha-beta(4)-alpha; mixed sheet: order 1765234
246. CorA soluble domain-like [143864] (1)
  beta(2)-alpha-beta-alpha(2)-beta(4)-alpha(3); 3 layers: a/b/a; mixed beta-sheet, order 2137654; strands 3 and 7 are parallel
247. Monooxygenase (hydroxylase) regulatory protein [56028] (1)
  corner-like structure formed by two sheets and filled in with 2-3 helices
248. PurM C-terminal domain-like [56041] (1)
  3 layers: alpha/beta/alpha; partial topological similarity to the ferredoxin-like fold
249. PF0523-like [143869] (1)
  beta-alpha-beta-alpha(3)-beta-alpha-beta-alpha; 3 layers, a/b/a; antiparallel beta-sheet, order 4132; some similarity to the PurM C-terminal domain-like fold (scop_cf 56041)
250. Chorismate synthase, AroC [103262] (1)
  duplication: consists of two DCoH-like beta(2)-alpha-beta(2)-alpha structural repeats; 3 layers, beta/alpha/beta
251. Hsp33 domain [64396] (1)
  3 layers: beta/alpha/beta; buried helix
252. MTH1598-like [69818] (1)
  beta(2)-alpha-beta-alpha-beta(4); 3 layers: beta/alpha/beta; some similarity to the Hsp33 fold
253. Protein-L-isoaspartyl O-methyltransferase, C-terminal domain [68929] (1)
  beta-alpha-beta(4)-alpha-beta(2); 3 layers: beta/alpha/beta; buried helix
254. OsmC-like [82783] (1)
  swapped dimer of beta(3)-alpha-beta(2)-alpha(2)-beta subunits; mixed beta-sheet; order: 321[4][5][6]; buried helix
255. Hypothetical protein HI1480 [103276] (1)
  beta-alpha(4)-beta-alpha-beta; segregated alpha-helical and beta-sheet subdomains; dimeric beta-sheet barrel: n=6, S=10
256. ERH-like [143874] (1)
  beta(2)-alpha(2)-beta(2)-alpha; antiparallel beta-sheet, order:2134; helices are arranged in a bundle rather than packed agains beta-sheet; dimerises via with the formation of a flattened beta-barel: closed n=8, S=10
257. Ribosomal protein S8 [56046] (1)
  consists of 2 different alpha+beta subdomains arranged in a 4-layer structure: b/a/b/a
258. Ribosomal protein L6 [56052] (1)
  consists of two beta-sheets and one alpha-helix packed around single core
259. NE0471 N-terminal domain-like [143879] (1)
  beta(3)-alpha(n)-beta(3)-alpha; the two meander beta-sheets and helices are packed against the same core
260. RGC domain-like [143884] (1)
  consists of two beta-sheets and four helices eclosing a cental cavity
261. Smc hinge domain [75552] (1)
  consists of 2 different alpha+beta subdomains; forms subdomain-swapped dimers
262. DNA mismatch repair protein MutL [118115] (1)
  consists of two different alpha+beta (sub)domains; d1: [beta(3)-alpha-(insert of d2)-alpha(2)-beta; 2 layers, a/b; antiparallel sheet, order: 1234]; d2: [beta-alpha-beta(2)-alpha(2); 2 layers, a/b; antiparallel sheet, order: 132]
263. ATP-grasp [56058] (2)
  Consists of two subdomains with different alpha+beta folds
  shares functional and structural similarities with the PIPK and protein kinase superfamilies
264. SAICAR synthase-like [56103] (1)
  consists of two alpha+beta subdomains
265. Protein kinase-like (PK-like) [56111] (1)
  consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
266. FAD-binding domain [56175] (1)
  consists of two alpha+beta subdomains
267. Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain [56193] (1)
  consists of two alpha+beta subdomains
268. Methenyltetrahydromethanopterin cyclohydrolase [56198] (1)
  consists of two alpha+beta subdomains
269. Prim-pol domain [56746] (1)
  consists of two alpha+beta domains
270. Hect, E3 ligase catalytic domain [56203] (1)
  consists of two alpha+beta domains; the N-terminal domain is array of helices and beta-hairpins; the C-terminal domain is an a/b sandwich with one left-handed beta-alpha(n)-beta unit; conformational flexibility of domain orientation
271. Nitrile hydratase alpha chain [56208] (1)
  4 layers a/b/b/a; inside is a sandwich of two 2-stranded beta-sheets
272. 4'-phosphopantetheinyl transferase [56213] (1)
  beta-alpha(3)-beta(2) motif
273. DNase I-like [56218] (1)
  contains beta-sandwich; duplication of alpha+beta motif
274. Aldehyde ferredoxin oxidoreductase, N-terminal domain [56227] (1)
  contains sandwich; duplication of alpha+beta motif with single mixed sheet
  motif: beta(2)-alpha-beta(3)-alpha-beta; strand order 216345, strands 1 and 6 are parallel
275. Ntn hydrolase-like [56234] (2)
  4 layers: alpha/beta/beta/alpha; has an unusual sheet-to-sheet packing
276. DmpA/ArgJ-like [56265] (1)
  duplication of beta(3)-alpha-beta-alpha motif; 4 layers: alpha/beta/beta/alpha
277. Pyruvoyl-dependent histidine and arginine decarboxylases [56270] (1)
  duplication of beta-alpha-beta(2) motif; 4 layers: alpha/beta/beta/alpha; contains "silk" beta-sandwich
278. S-adenosylmethionine decarboxylase [56275] (1)
  duplication of beta-alpha-beta(4)-alpha-beta-alpha-beta(2) motif; 4 layers a/b/b/a; antiparallel beta-sheets: order 23451687
279. Metallo-hydrolase/oxidoreductase [56280] (1)
  duplication of beta(4)-alpha-beta-alpha motif; 4 layers a/b/b/a; mixed beta-sheets
280. PP2C-like [81607] (1)
  4 layers: alpha/beta/beta/alpha; antiparallel beta sheets
281. Metallo-dependent phosphatases [56299] (1)
  4 layers: alpha/beta/beta/alpha; mixed beta sheets; contains duplication
282. Carbon-nitrogen hydrolase [56316] (1)
  4 layers: alpha/beta/beta/alpha; mixed beta sheets; contains duplication
283. CNF1/YfiH-like putative cysteine hydrolases [64437] (1)
  4 layers: alpha/beta/beta/alpha; mixed beta sheets
284. ADC synthase [56321] (1)
  duplication: contains four repeats of alpha-beta(2)-beta motif arranged in a 4 layer core structure: alpha/beta/beta/alpha; orthogonally packed beta-sheets
285. Sulfolobus fructose-1,6-bisphosphatase-like [111248] (1)
  4 layers: a/b/b/a; antiparallel beta sheets; similarities to ferredoxin-like fold (scop_cf 54861) in the N-terminal part (1-120) and to the Bacterial S-adenosylmethionine decarboxylase subunit (scop_fa 997656) in the C-terminal part (121-340)
286. LDH C-terminal domain-like [56326] (1)
  unusual fold, defines family
287. DNA breaking-rejoining enzymes [56348] (1)
  core: alpha3-beta3-alpha4; one side of beta-sheet is exposed
288. Replication modulator SeqA, C-terminal DNA-binding domain [82807] (1)
  consists of seven alpha-helices and three-stranded beta-sheet
289. SMAD MH1 domain [56365] (1)
  consists of four alpha-helices and three beta-ribbons
290. YopH tyrosine phosphatase N-terminal domain [64448] (1)
  consists of four alpha-helices and two beta-hairpins
291. Rotavirus NSP2 fragment, N-terminal domain [75573] (1)
  consists of six alpha-helices and two beta-hairpins
292. Ribosome inactivating proteins (RIP) [56370] (1)
  contains mixed beta-sheet
293. ADP-ribosylation [56398] (1)
  unusual fold
294. Peptide deformylase [56419] (1)
  alpha-beta(5)-alpha; 3 layers: a/b/a; meander beta-sheet wraps around the C-terminal alpha-helix
295. LCCL domain [69847] (1)
  unusual fold
296. Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain [56424] (1)
  unusual fold
297. C-type lectin-like [56435] (1)
  unusual fold
298. Hemolytic lectin CEL-III, C-terminal domain [111264] (1)
  unusual fold
299. SRCR-like [56486] (2)
  unusual fold; disulfide-rich; core: beta-x-alpha-beta-loop-beta
300. Fibrinogen C-terminal domain-like [56495] (1)
  unusual fold
301. gp120 core [56501] (1)
  unusual fold
302. Methionine synthase activation domain-like [56506] (1)
  unusual fold; core: beta-alpha(2)-beta(2)-alpha(2)-beta-alpha-beta; antiparallel beta-sheet: order 12354
303. UbiD C-terminal domain-like [143967] (1)
  alpha-beta(2)-alpha-beta-alpha-beta(2); 3 layers, a/b/a; mixed beta-sheet, order: 12354, strands 2,3 and 5 are parallel to each other
304. Hypothetical protein TM0875 [90063] (1)
  unusual fold; core: beta(2)-loop-beta(2)-alpha-beta; mixed beta-sheet: order 51243; parallel strands 2 and 4
305. Metal cation-transporting ATPase, ATP-binding domain N [81661] (1)
  unusual fold; core: beta-alpha(2)-beta(3)-alpha(2)-beta(2); 6-stranded antiparallel beta-sheet, order: 165432
306. Suppressor of Fused, N-terminal domain [103358] (1)
  unusual fold; bifurcated beta-sheet; left-handed beta-alpha-beta unit
307. Nitric oxide (NO) synthase oxygenase domain [56511] (1)
  unusual fold
308. Penicillin binding protein dimerisation domain [56518] (1)
  unusual fold
309. Oxidoreductase molybdopterin-binding domain [56523] (1)
  unusual fold; contains 3 layers of beta-sheet structure and a beta-grasp like motif
310. FAH [56528] (1)
  unusual fold; contains 3 layers of beta-sheet structure
311. Aromatic aminoacid monoxygenases, catalytic and oligomerization domains [56533] (1)
  unusual fold
312. Substrate-binding domain of HMG-CoA reductase [56541] (1)
  unusual fold
313. Argininosuccinate synthetase, C-terminal domain [69863] (1)
  unusual fold
314. Hypothetical protein PH1602 [103364] (1)
  complex alpha+beta fold; contains a region of similarity to the ferredoxin-like fold
315. IlvD/EDD N-terminal domain-like [143974] (1)
  contains a large cluster of helices and a mixed beta-sheet of 4 strands; order 2134, strands 3 and 4 are parallel
316. DNA methylase specificity domain [116733] (1)
  comprises the N-terminal, double beta-helix like structure and C-terminal alpha-hairpin
317. GCM domain [90072] (1)
  consists of two different alpha+beta subdomains; 2 zinc-binding sites
318. Conserved core of transcriptional regulatory protein vp16 [56547] (1)
  unusual fold
319. Insert subdomain of RNA polymerase alpha subunit [56552] (1)
  unusual fold; contains a left-handed beta-alpha-beta unit
320. Baseplate structural protein gp11 [56557] (1)
  unusual fold; trimer
321. Receptor-binding domain of short tail fibre protein gp12 [88873] (1)
  unusual fold; trimer
322. Outer capsid protein sigma 3 [64464] (1)
  unusual fold
323. Phosphoprotein M1, C-terminal domain [118172] (1)
  consists of 6 helices and one beta-hairpin
324. L,D-transpeptidase pre-catalytic domain-like [143984] (1)
  unusual fold, made of four helices and four 2-3 stranded beta-sheets
325. YbiA-like [143989] (1)
  consists of six alpha-helices and two two-stranded beta-sheets
326. NinB [103369] (1)
  unusual fold; intertwined dimer; consists of two different structural domains
327. AF2331-like [143994] (1)
  interlocked dimer of beta-alpha-beta(2)-alpha-beta-(alpha) subunits; 3 layers: b/b/a
328. SSo0622-like [111277] (1)
  alpha(2)-beta(2)-alpha-beta-alpha-beta(2)-alpha; 2 layers: a/b; antiparallel beta-sheet: order 21354; strands 1,3 and 5 and the C-terminal helix are longer than other secondary structures
329. Putative modulator of DNA gyrase, PmbA/TldD [111282] (1)
  consists of two different alpha+beta domains; d1: [duplication of alpha-beta(3)-alpha motif; 2 layers: a/b; antiparallel beta-sheet, order: 321456; strands 1, 2, 4 and 5 are twice longer than other secondary structures]; d2 [ complex fold; contains beta-barrel (n=5, S=10)]
330. Oxysterol-binding protein-like [143999] (1)
  core: large meander beta-sheet of 12 strands wrapped around the N-terminal (distorted) alpha-hairpin; some similarity to transmembrane beta-barrel proteins
331. ORC1-binding domain [144004] (1)
  complex fold, composed of an alpha hairpin, meander beta-sheet and a five-stranded barrel of unusual topology
332. CofE-like [144009] (1)
  consists of two different domains; d1: beta-alpha-beta-alpha-beta(2)-alpha-beta, mixed sheet of 5 strands, order:15234, strands 2 and 3 are parralel; d2 is inserted in d1 after strand 2 and comprises a helix-turn-helix motif and two 3-stranded sheets
333. Peptidoglycan deacetylase N-terminal noncatalytic region [144014] (1)
  consists of two different domains, d1: [alpha-beta(2)-alpha-beta(3); 3 layers: a/b/a; mixed beta-sheet, order 12345, strands 2 and 3 are parallel to each other with a left-handed crossover connection], d2: alpha-beta(3)-alpha; 2 layers; antiparallel beta-sheet, order 123]
334. Non-globular alpha+beta subunits of globular proteins [56567] (1)
  not a true fold
Multi-domain proteins (alpha and beta) [56572] (53)
Folds consisting of two or more domains belonging to different classes
1. Serpins [56573] (1)
  contains a cluster of helices and a beta-sandwich
2. FdhE-like [144019] (1)
  consists on the N-terminal five-helical bundle, a tandem repeat of two rubredoxin-like domains and the C-terminal helix packed together
3. Replication terminator protein (Tus) [56595] (1)
  contains a cluster of helices and a beta-sandwich
4. 2-methylcitrate dehydratase PrpD [103377] (1)
  consists of an all-alpha and alpha+beta domains
5. Antivirulence factor [103382] (1)
  contains a helical bundle with a buried helix and an alpha+beta insert domain
6. Virulence-associated V antigen [103387] (1)
  consists of an all-alpha and alpha+beta domains connected by antiparallel coiled coil
7. Heme-dependent catalase-like [56633] (1)
  contains an (8,10) beta-barrel and an all-alpha domain
8. Acyl-CoA dehydrogenase NM domain-like [56644] (1)
  2 domains: (1) all-alpha: 5 helices; (2) contains an open beta-sheet barrel: n*=5, S*=8; complex topology
9. Carbohydrate phosphatase [56654] (1)