Structural Classification of Proteins

Fold: Four-helical up-and-down bundle

: core: 4 helices; bundle, closed or partly opened, left-handed twist; up-and-down

Lineage:

Root: scop
Class: All alpha proteins [46456]
Fold: Four-helical up-and-down bundle [47161]
core: 4 helices; bundle, closed or partly opened, left-handed twist; up-and-down

Superfamilies:

Apolipoprotein [47162] (1)
Aspartate receptor, ligand-binding domain [47170] (1)
Cytochromes [47175] (2)
Heme-containing proteins
Hemerythrin [47188] (1)
TMV-like viral coat proteins [47195] (1)
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) [47212] (1)
Proteasome activator reg(alpha) [47216] (1)
alpha-catenin/vinculin-like [47220] (2)
FAT domain of focal adhesion kinase [68993] (1)
Oxygen-evolving enhancer protein 3, [101112] (1)
Histidine-containing phosphotransfer domain, HPT domain [47226] (5)
contains additional, fifth helix at the N-terminus
Bacterial GAP domain [47233] (1)
contains extra helices in the loops at one end of the bundle
Outer surface protein C (OspC) [63515] (1)
Flagellar export chaperone FliS [101116] (1)
can form closed, open and helix-swapped bundles
Domain of the SRP/SRP receptor G-proteins [47364] (1)
FAD-dependent thiol oxidase [69000] (1)
Group V grass pollen allergen [81736] (1)
Nucleotidyltransferase substrate binding subunit/domain [81593] (4)
RecG, N-terminal domain [69008] (1)
Colicin D immunity protein [101125] (1)
Nickel-containing superoxide dismutase, NiSOD [109770] (1)
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain [109775] (1)
contains extra alpha+beta subdomain formed by the N- and C-termini.
Domain from hypothetical 2610208m17rik protein [109779] (1)
TrmE connector domain [116878] (1)
YppE-like [140415] (1)
flattened bundle at one end with helices 2 and coming in contact and separating helices 1 and 3
MW0975(SA0943)-like [140423] (1)
open bundle; there is a long groove between helices 1 and 4
VPS28 C-terminal domain-like [140427] (1)