Structural Classification of Proteins

Fold: Ferritin-like

: core: 4 helices; bundle, closed, left-handed twist; 1 crossover connection

Lineage:

Root: scop
Class: All alpha proteins [46456]
Fold: Ferritin-like [47239]
core: 4 helices; bundle, closed, left-handed twist; 1 crossover connection

Ferritin-like [47240] (5)
contains bimetal-ion centre in the middle of the bundle
1. Ferritin [47241] (34)
2. Ribonucleotide reductase-like [47253] (17)
3. Manganese catalase (T-catalase) [100951] (2)
4. YciF-like [140445] (2)
  Pfam 05974; DUF892
5. half-ferritin [140450] (1)
  comprise of alpha-hairpin subunits forming the ferritin-like four-helical bundle; assembles further in a homodecamer
Cobalamin adenosyltransferase-like [89028] (2)
crossover loop goes across a different side of the 4-helical bundle; no internal metal-binding site
1. Cobalamin adenosyltransferase [89032] (2)
2. Hypothetical protein Ta1238 [89029] (1)
EsxAB dimer-like [140453] (1)
(hetero)dimer of alpha-hairpin subunits similar to that of the half-ferritin family; no bound metals
1. ESAT-6 like [140454] (2)
  Pfam 06013; the conserwed WxG motif makes the turn at the alpha-hairpin tip
PE/PPE dimer-like [140459] (2)
(hetero)dimer of alpha-hairpin subunits similar to that of the half-ferritin family; no bound metals inside the bundle
1. PE [140460] (1)
  Pfam 00934; pairs with with the N-terminal hairpin of PPE
2. PPE [140463] (1)
  Pfam 00823; contains extra C-terminal alpha-hairpin, unlike the PE family subunit