Structural Classification of Proteins
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Fold: lambda repressor-like DNA-binding domains

core: 4 helices; folded leaf, closed

Lineage:

  1. Root: scop
  2. Class: All alpha proteins [46456]
  3. Fold: lambda repressor-like DNA-binding domains [47412]
    core: 4 helices; folded leaf, closed

Superfamilies:

  1. lambda repressor-like DNA-binding domains [47413] (13)
    1. POU-specific domain [47414] (3)
      1. Oct-1 [47415]
        canonical 4-helical fold
        1. Human (Homo sapiens) [TaxId: 9606] [47416] (7) picpic
      2. Pit-1 [47417]
        1. Rat (Rattus norvegicus) [TaxId: 10116] [47418] (1) picpic
      3. Hepatocyte nuclear factor 1a (LFB1/HNF1) [81748]
        atypical POU domain with extra N-terminal helix
        1. Human (Homo sapiens) [TaxId: 9606] [81749] (1) picpic
    2. Phage repressors [47419] (7)
      consists of different sequence families of HTH repressors of phage origins
      1. lambda C1 repressor, DNA-binding domain [47420]
        1. Bacteriophage lambda [TaxId: 10710] [47421] (6) picpic
      2. 434 C1 repressor, DNA-binding domain [47422]
        1. Bacteriophage 434 [TaxId: 10712] [47423] (8) picpic
      3. cro 434 [47424]
        1. Bacteriophage 434 [TaxId: 10712] [47425] (3) picpic
          contains a short additional helix at C-terminus
      4. P22 C2 repressor, DNA-binding domain [47426]
        1. Salmonella bacteriophage P22 [TaxId: 10754] [47427] (1) picpic
          contains a short additional helix at C-terminus
      5. cro lambda repressor [47428]
        the fourth helix is replaced with a beta hairpin
        3 helices; folded leaf, opened
        1. Bacteriophage lambda [TaxId: 10710] [47429] (9) picpic
      6. Ner [47430]
        1. Bacteriophage mu [TaxId: 10677] [47431] (2) picpic
      7. cro p22 [109809]
        1. Bacteriophage p22 [TaxId: 10754] [109810] (1) picpic
    3. SinR domain-like [47432] (5)
      1. SinR repressor, DNA-binding domain [47433]
        1. Bacillus subtilis [TaxId: 1423] [47434] (1) picpic
      2. Putative transcription regulator CylR2 [109811]
        1. Enterococcus faecalis [TaxId: 1351] [109812] (3) picpic
      3. Regulatory protein C.BclI [140512]
        1. Bacillus caldolyticus [TaxId: 1394] [140513] (4) picpic
      4. Restriction-modification controller protein C.AhdI [140514]
        1. Aeromonas hydrophila [TaxId: 644] [140515] (2) picpic
      5. Hydroxypropylphosphonic acid epoxidase Fom4, N-terminal domain [140516]
        1. Streptomyces wedmorensis [TaxId: 43759] [140517] (20) picpic
    4. Cyanase N-terminal domain [47435] (1)
      probably does not bind to DNA
      1. Cyanase N-terminal domain [47436]
        1. Escherichia coli [TaxId: 562] [47437] (22) picpic
    5. GalR/LacI-like bacterial regulator [47438] (4)
      lacks the first helix of canonical fold
      3 helices; bundle, partly opened, right-handed twist
      1. Purine repressor (PurR), N-terminal domain [47439]
        1. Escherichia coli [TaxId: 562] [47440] (24) picpic
      2. Lac repressor (LacR), N-terminal domain [47441]
        1. Escherichia coli [TaxId: 562] [47442] (11) picpic
      3. Fructose repressor (FruR), N-terminal domain [47443]
        1. Escherichia coli [TaxId: 562] [47444] (2) picpic
      4. Glucose-resistance amylase regulator CcpA, N-terminal domain [116889]
        1. Bacillus megaterium [TaxId: 1404] [116890] (5) picpic
    6. YdiL-like [109813] (1)
      contains extra C-terminal all-alpha dimerization subdomain; the dimer may bind DNA
      1. Putative cytoplasmic protein YdiL [109814]
        1. Salmonella typhimurium [TaxId: 602] [109815] (1) picpic
    7. CUT domain [116891] (4)
      Pfam 02376
      1. Homeobox protein Cux-2, CUTL2 [116892]
        1. Human (Homo sapiens) [TaxId: 9606] [116893] (3) picpic
      2. DNA-binding protein SATB2 [116894]
        1. Human (Homo sapiens) [TaxId: 9606] [116895] (2) picpic
      3. Hepatocyte nuclear factor 6 [116896]
        1. Mouse (Mus musculus) [TaxId: 10090] [116897] (1) picpic
      4. DNA-binding protein SATB1 [140518]
        1. Human (Homo sapiens) [TaxId: 9606] [140519] (1) picpic
    8. Probable transcriptional regulator VC1968, N-terminal domain [116898] (1)
      1. Probable transcriptional regulator VC1968, N-terminal domain [116899]
        1. Vibrio cholerae [TaxId: 666] [116900] (1) picpic
    9. Bacteriophage CII protein [140520] (1)
      Pfam 05269; a compact helix-swapped dimer of the canonical fold; includes the extra C-terminal teramerisation region (alpha-helix); in the tetramer-DNA complex only two of the four HTH motifs interact with DNA
      1. Regulatory protein cII [140521]
        1. Bacteriophage lambda [TaxId: 10710] [140522] (12) picpic
    10. NE0471 C-terminal domain-like [140523] (1)
      1. Hypothetical protein NE0471 C-terminal domain [140524]
        1. Nitrosomonas europaea [TaxId: 915] [140525] (2) picpic
    11. PrgX N-terminal domain-like [140526] (1)
      Part of Pfam 01381
      1. PrgX [140527]
        possibly involved in pheromone-inducible conjugation
        1. Enterococcus faecalis [TaxId: 1351] [140528] (38) picpic
    12. EDF1-like [140529] (1)
      part of Pfam 01381
      1. Endothelial differentiation-related factor 1, EDF1 [140530]
        1. Human (Homo sapiens) [TaxId: 9606] [140531] (1) picpic
    13. NE1354 [140532] (1)
      contains extra C-terminal dimerisation arm (beta-strand)
      1. HTH-motif protein NE1354 [140533]
        1. Nitrosomonas europaea [TaxId: 915] [140534] (2) picpic
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MRC site Generated from scop database 1.73 with scopm 1.101 on Wed Nov 21 11:18:32 2007
Copyright © 1994-2007 The scop authors / scop@mrc-lmb.cam.ac.uk