Structural Classification of Proteins




Class: All alpha proteins
Lineage:
- Root: scop
- Class: All alpha proteins [46456]
Folds:
- Globin-like [46457] (2)

core: 6 helices; folded leaf, partly opened
- Long alpha-hairpin [46556] (19)

2 helices; antiparallel hairpin, left-handed twist
- Type I dockerin domain [63445] (1)

tandem repeat of two calcium-binding loop-helix motifs, distinct from the EF-hand
- LEM/SAP HeH motif [63450] (5)

helix-extended loop-helix; parallel helices
- RPB6/omega subunit-like [63561] (1)

core: 2 helices and adjacent loops
- KRAB domain (Kruppel-associated box) [109639] (1)

2 helices: one short, one long; aromatic-rich iterface
- Cytochrome c [46625] (1)

core: 3 helices; folded leaf, opened
- DNA/RNA-binding 3-helical bundle [46688] (14)

core: 3-helices; bundle, closed or partly opened, right-handed twist; up-and down
- Another 3-helical bundle [81602] (5)

topologically similar to the DNA/RNA-binding bundles; distinct packing
- RuvA C-terminal domain-like [46928] (9)

3 helices; bundle, right-handed twist
- S13-like H2TH domain [81297] (1)

core: 3-4 helices
- Putative DNA-binding domain [46954] (1)

core: 3 helices; architecture is similar to that of the "winged helix" fold but topology is different
- Spectrin repeat-like [46965] (15)

3 helices; bundle, closed, left-handed twist; up-and-down
- immunoglobulin/albumin-binding domain-like [46996] (10)

3 helices; bundle, closed, left-handed twist; up-and-down; mirror topology to the spectrin-like fold
- Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex [47004] (1)

3 helices; bundle, closed, right-handed twist; up-and-down
- ChaB-like [140375] (1)

3 helices, the first one is shorter than the other two; bundle, capped by a small, C-terminal beta-hairpin
- Protozoan pheromone-like [47013] (2)

3 helices; bundle, closed, left-handed twist, up-and-down
- Acyl-CoA binding protein-like [47026] (2)

core: 3 helices; bundle, closed, left-handed twist; up-and-down
- Kix domain of CBP (creb binding protein) [47039] (1)

3 helices; bundle, partly opened
- RAP domain-like [47044] (1)

3 helices, the first one is shorter than the other two; bundle, partly opened
- VHP, Villin headpiece domain [47049] (1)

3 short helices; irregular array
- BSD domain-like [140382] (1)

core: 3 helices; triangular array; the extra N-terminal and C-terminal helices form a coiled coil structure
- TAF(II)230 TBP-binding fragment [47054] (1)

3 short helices; irregular array
- S15/NS1 RNA-binding domain [47059] (1)

3 helices; irregular array
- Frizzled cysteine-rich domain [63500] (1)

Core: 3 helices; irregular array; disulfide-rich
- T4 endonuclease V [47076] (1)

3 helices; irregular array
- Fertilization protein [47081] (1)

core: 3 helices; bundle, closed, right-handed twist; up-and-down
- PGBD-like [47089] (1)

core: 3 helices; bundle, closed, left-handed twist; parallel
- HMG-box [47094] (1)

3 helices; irregular array
- Histone-fold [47112] (1)

core: 3 helices; long middle helix is flanked at each end with shorter ones
- Open three-helical up-and-down bundle [47143] (6)

core: 3 helices; bundle, open
- beta-catenin-interacting protein ICAT [81729] (1)

core: 3 helices; irregular array
- DNA polymerase III theta subunit-like [116730] (1)

3 helices; irregular array
- Four-helical up-and-down bundle [47161] (27)

core: 4 helices; bundle, closed or partly opened, left-handed twist; up-and-down
- PTS-regulatory domain, PRD [63519] (1)

core: 4 helices; bundle, closed, right-handed twist; 1 crossover connection
- Ferritin-like [47239] (4)

core: 4 helices; bundle, closed, left-handed twist; 1 crossover connection
- 4-helical cytokines [47265] (1)

core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
- Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases [47322] (1)

core: 4 helices; bundle; one loop crosses over one side of the bundle
- Acyl carrier protein-like [47335] (3)

4 helices, bundle; helix 3 is shorter than others; up-and-down
- Bromodomain-like [47363] (10)

4 helices; bundle; minor mirror variant of up-and-down topology
- ROP-like [47379] (8)

4 helices; dimer of identical alpha-hairpin subunits; bundle, closed, left-handed twist
- Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit [47390] (1)

4 helices; bundle, closed, right-handed twist
- Soluble domain of poliovirus core protein 3a [89042] (1)

4 helices; bundle, closed, right-handed twist
- Transcription factor IIA (TFIIA), alpha-helical domain [47395] (1)

4 helices; bundle, closed, right-handed twist
- Ectatomin subunits [47400] (1)

4 helices; bundle, closed, left-handed twist
- Dimerisation interlock [47405] (4)

4 helices; bundle, closed, right-handed twist
- lambda repressor-like DNA-binding domains [47412] (1)

core: 4 helices; folded leaf, closed
- Signal peptide-binding domain [47445] (1)

4 helices; orthogonal array
- A DNA-binding domain in eukaryotic transcription factors [47453] (1)

4 helices; the long C-terminal helix protrudes from the domain and binds to DNA
- HLH-like [47458] (2)

4-helices; bundle, closed, left-handed twist; 2 crossover connections
- EF Hand-like [47472] (4)

core: 4 helices; array of 2 hairpins, opened
- CH domain-like [47575] (3)

core: 4 helices: bundle
- Domain of poly(ADP-ribose) polymerase [47586] (1)

core: 4 helices: bundle; unusual topology
- SWIB/MDM2 domain [47591] (1)

core: 4 helices: open bundle; capped by two small 3-stranded beta-sheets
duplication: consists of two structural repeats
- Pre-protein crosslinking domain of SecA [81766] (1)

core: 4 helices: bundle; flanked by two short beta-hairpins
duplication: consists of two structural repeats
- Ribbon-helix-helix [47597] (1)

core: 4 helices; array of 2 hairpins, opened
- Glutathione S-transferase (GST), C-terminal domain [47615] (1)

core: 4 helices; bundle, closed, left-handed twist; right-handed superhelix
- Methionine synthase domain-like [47643] (3)

4 helices; bundle, left-handed twist; right-handed superhelix
- KaiA/RbsU domain [101214] (1)

4 helices; bundle, right-handed twist; right-handed superhelix
- STAT-like [47654] (6)

4 long helices; bundle, left-handed twist (coiled coil); right-handed superhelix
- N-cbl like [47667] (4)

4 helices; bundle, left-handed twist; left-handed superhelix
- Replisome organizer (g39p helicase loader/inhibitor protein) [89063] (1)

4 helices; bundle, right-handed twist; left-handed superhelix
- Hypothetical protein YqbG [116914] (1)

core: 4 helices; bundle, right-handed twist; left-handed superhelix
- C-terminal domain of B transposition protein [47680] (1)

4 helices; irregular array
- HAND domain of the nucleosome remodeling ATPase ISWI [101223] (1)

4 helices; irregular array
- N-terminal, cytoplasmic domain of anti-sigmaE factor RseA [89068] (1)

4 helices; irregular array
- Anaphylotoxins (complement system) [47685] (1)

4 helices; irregular array, disulfide-linked
- Cytochrome c oxidase subunit h [47693] (1)

4 helices; irregular array, disulfide-linked
- Crustacean CHH/MIH/GIH neurohormone [81777] (1)

4 helices; irregular array, disulfide-linked
- C-terminal domain of DFF45/ICAD (DFF-C domain) [81782] (1)

4 helices; folded leaf; right-handed superhelix
- Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin [47698] (1)

4 helices; folded leaf; right-handed superhelix
- p53 tetramerization domain [47718] (1)

core: 4 helices; bundle
- Bcr-Abl oncoprotein oligomerization domain [69035] (1)

core: 4 long helices; bundle
- Domain of early E2A DNA-binding protein, ADDBP [47723] (1)

4 helices; bundle, partly opened
- IHF-like DNA-binding proteins [47728] (1)

core: 4 helices; bundle, partly opened, capped with a beta-sheet
- TraM-like [140580] (1)

multihelical oligomeric protein; structure of whole subunit is not known; the N-terminal part is implicated in DNA binding, the middle region forms tetrameric parallel coiled coil, surrounded by the C-terminal helices
- CO dehydrogenase ISP C-domain like [47740] (1)

core: 4 helices, bundle
- Protein HNS-dependent expression A; HdeA [47751] (1)

4 helices; the three last helices form a bundle similar to that of the RuvA C-domain
- PABP domain-like [63569] (2)

4 helices; an orthogonal array
- Chemotaxis receptor methyltransferase CheR, N-terminal domain [47756] (1)

4 helices; an orthogonal array
- Dcp2 domain-like [140585] (1)

4 helices; orthogonal array of two alpha hairpins
- Type III secretion system domain [140590] (1)

core: 4 helices, orthogonal array; right-handed superhelix
- YugE-like [116921] (1)

4-helices; bundle; right-handed twist
- PWI domain [101232] (1)

4 helices; up-and-down bundle; topological similarity to the bromodomain-like and SAM domain-like folds
- PAH2 domain [47761] (1)

4 helices; open up-and-down bundle; binds alpha-helical peptides
- Myosin phosphatase inhibitor 17kDa protein, CPI-17 [81789] (1)

4 helices; open up-and-down bundle; flexible N-terminal tail
- XPC-binding domain [101237] (1)

4 helices; array
- DinB/YfiT-like putative metalloenzymes [109853] (1)

core: 4 helices; bundle, closed, left-handed twist; an unusual topology with a higher contact order
- EspA/CesA-like [116926] (1)

4 helices; bundle, closed, left ight-handed twist; interlocked (hetero)dimer of 2-helical subunits
- NblA-like [109858] (1)

4 helices; dimer of identical alpha-hairpin subunits; open bundle
- EF2947-like [140606] (1)

4 helices; "diamond" array; duplication: N-terminal and C-terminal pairs of helices are related by pseudo dyad
- EB1 dimerisation domain-like [140611] (1)

dimeric 4-helical bundle with a coiled coil at one end formed by the longer N-terminal helices
- SAM domain-like [47768] (15)

4-5 helices; bundle of two orthogonally packed alpha-hairpins; involved in the interactions with DNA and proteins
- Retroviral matrix proteins [47835] (1)

4-5 helices; right-handed superhelix
- Flavivirus capsid protein C [101256] (1)

core: 5 helices; right-handed superhelix; swapped dimer with the two long C-terminal helices
- Hepatitis B viral capsid (hbcag) [47851] (1)

5 helices; array; two long helices form a hairpin that dimerizes into a 4-helical bundle
- Apolipophorin-III [47856] (1)

5 helices; bundle, closed, left-handed twist
- Methenyltetrahydrofolate cyclohydrolase-like [101261] (1)

5 helices; bundle, closed, left-handed twist
- A middle domain of Talin 1 [109879] (1)

5 helices; bundle, closed, left-handed twist; helices 2-5 adopt the Four-helical up-and-down bundle fold (scop_cf 47161)
- I/LWEQ domain [109884] (1)

5 helices; bundle, closed, left-handed twist
- RNA-binding protein She2p [116941] (1)

5 helices; bundle, closed, left-handed twist; topological similarity to the middle domain of the L-aspartase-like fold (scop_cf 48556)
- Hyaluronidase domain-like [140656] (2)

5 helices; bundle, closed, left-handed twist; up-and-down (meander) topology
- YoaC-like [140669] (1)

5 helices; bundle, one crossover connection, the arrangement of the first four helices is similar to the KaiA/RbsU domain fold (scop_cf 101214)
- Saposin-like [47861] (2)

5 helices; folded leaf, closed
- Annexin [47873] (1)

5 helices; folded leaf, closed
- Transducin (alpha subunit), insertion domain [47894] (1)

5 helices; folded leaf
- Wiscott-Aldrich syndrome protein, WASP, C-terminal domain [47911] (1)

5 helices; irregular array; left-handed superhelix
- Left-handed superhelix [47916] (3)

core: 4-5 helices; bundle; left-handed superhelix
- N-terminal domain of the delta subunit of the F1F0-ATP synthase [47927] (1)

core: 5 helices; bundle
- ERP29 C domain-like [47932] (2)

5 helices; bundle
- Functional domain of the splicing factor Prp18 [47937] (1)

core: 5 helices; bundle
- Retrovirus capsid protein, N-terminal core domain [47942] (1)

core: 5 helices; bundle
- Cyclin-like [47953] (1)

core: 5 helices; one helix is surrounded by the others
- Arp2/3 complex 21 kDa subunit ARPC3 [69059] (1)

5 helices; one helix is surrounded by the others
- RNase III domain-like [69064] (1)

core: 5 helices; one helix is surrounded by the others
- Ribosomal protein S7 [47972] (1)

core: 5 helices; contains one more helix and a beta-hairpin outside the core
- DNA polymerase III clamp loader subunits, C-terminal domain [48018] (1)

core: 5 helices: bundle
- PAP/OAS1 substrate-binding domain [81632] (1)

core: 5-helical bundle; up-and-down; right-handed twist
- Anti-sigma factor AsiA [69069] (1)

core: 5 helices: orthogonal array
- Antibiotic binding domain of TipA-like multidrug resistance regulators [89081] (1)

5 helices: orthogonal array
- Surp module (SWAP domain) [109904] (1)

5 helices: irregular array
- YgfY-like [109909] (1)

5 helices; array; forms a tight dimer in crystals
- Hypothetical protein YhaI [109914] (1)

core: 5 helices; orthogonal array; folding similarity to the TipA-S domain (1ny9)
- Hypothetical protein At3g22680 [109919] (1)

5 helices; array; probable biological unit is a homodimer
- SP0561-like [140682] (1)

5 helices; array; includes extra N-terminal and C-terminal short strands forming parrallel beta-sheet ladder
- YfmB-like [140687] (1)

5 helices, array; buried N-terminal helix; some topological similarity (circular permutation?) to the Nucleotidyltransferase substrate binding subunit/domain (scop_sf 81593)
- N-terminal domain of adenylylcyclase associated protein, CAP [101277] (1)

6 helices: bundle; left-handed twist, up-and-down topology
- IpaD-like [140692] (1)

6 helices; bundle, up-and-down; can be divided into two four-helical bundles sharing two helices (3 and 6), which are twice longer than the rest
- Iron-dependent repressor protein, dimerization domain [47978] (1)

6 helices, homodimer of 3-helical domains
- Glutamyl tRNA-reductase dimerization domain [69074] (1)

6 helices, homodimer of 3-helical domains
- GRIP domain [101282] (1)

6 helices, homodimer of 3-helical domains
- BAR/IMD domain-like [116747] (1)

6 helices, homodimer of 3-helical domains
- L27 domain [101287] (1)

6 helices, heterodimer of 3-helical domains
- Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain [109924] (1)

dimer of 3-helical segments; consists of two subdomains: 4-helical bundle and coiled coil
- Phage replication organizer domain [140712] (1)

6 helices, homodimer of 3-helical domains
- Mediator hinge subcomplex-like [140717] (1)

6 helices; heterodimer of structurally similar subunits; the N-terminal hairpins form a four-helical bundle, whereas the C-terminal helices form coiled coil structure
- DEATH domain [47985] (1)

6 helices: closed bundle; greek-key; internal pseudo twofold symmetry
- Fatty acid responsive transcription factor FadR, C-terminal domain [48007] (1)

core: 6 helices: closed bundle; greek-key; internal pseudo twofold symmetry
- AF0941-like [140725] (1)

6 helices, arranged into two interconnected 3-helical bundles; can also be described as a 'kinked' four-helical bundle; right-handed superhelix
- NusB-like [48012] (1)

6 helices: bundle; one central helix is surrounded by 5 others
- YutG-like [101306] (1)

core: 6 helices; bundle; one central helix is surrounded by 5 others
- N-terminal domain of DnaB helicase [48023] (1)

6 helices: array
- Invasion protein A (SipA) , C-terminal actin binding domain [101311] (1)

6 helices: orthogonal array
- Guanido kinase N-terminal domain [48033] (1)

irregular array of 6 short helices
- Scaffolding protein gpD of bacteriophage procapsid [48044] (1)

core: 6 helices; one central helix is surrounded by 5 others
- Hemocyanin, N-terminal domain [48049] (1)

6 helices; bundle; one central helix is surrounded by 5 others
- Di-copper centre-containing domain [48055] (1)

multihelical
- DBL homology domain (DH-domain) [48064] (1)

multihelical; core: 5-helical bundle
- LigA subunit of an aromatic-ring-opening dioxygenase LigAB [48075] (1)

multihelical; contains compact array of 6 short helices
- RuBisCo LSMT C-terminal, substrate-binding domain [81821] (1)

multihelical; irregular array of long and short helices
- Methyl-coenzyme M reductase alpha and beta chain C-terminal domain [48080] (1)

multihelical bundle; contains buried central helix
- YcfC-like [101321] (1)

multihelical; contains two buried central helices
- PA2201 C-terminal domain-like [140730] (1)

multihelical; seven-helical bundle with buried central helix
- Rv1873-like [140735] (1)

multihelical; contains unusually short buried central helix
- RUN domain-like [140740] (1)

multihelical; 3-helical bundle similar to one half of the DEATH domain fold is flanked by two alpha-hairpins forming a four-helical bundle; the axes of the three-helical and four-helical bundles are aproximately orthogonal to each other
- SipA N-terminal domain-like [140745] (1)

multihelical; bundle; the last helix is buried inside the bundle
- Transcription factor STAT-4 N-domain [48091] (1)

multihelical; can be divided into two subdomains
- Regulator of G-protein signaling, RGS [48096] (1)

multihelical; consists of two all-alpha subdomains
contains a 4-helical bundle with left-handed twist and up-and-down topology
- SopE-like GEF domain [81831] (1)

multihelical; consists of two all-alpha subdomains each containing a 3-helical bundle with right-handed twist
- Variable surface antigen VlsE [74747] (1)

multihelical; consists of two all-alpha subdomains; contains a 4-helical bundle with left-handed twist and up-and-down topology
- YgfB-like [101326] (1)

multihelical; consists of two tightly associated 3-helical bundles with different twists
- Hypothetical protein MTH393 [101331] (1)

multihelical; consists of two all-alpha subdomains; dimer
- PG0816-like [140752] (1)

multihelical; comprises two helical bundles, both are topologically similar to the RuvA C-terminal domain-like fold (scop_cf 46928)
- Carbamoyl phosphate synthetase, large subunit connection domain [48107] (1)

multihelical; consists of two all-alpha subdomains
possible duplication: subdomains have similar topologies
- Heme-dependent peroxidases [48112] (1)

multihelical; consists of two all-alpha domains
- Ribosomal protein L19 (L19e) [48139] (1)

multihelical; consists of two different 3-helical domains connected by a long, partly helical linker
- GatB/YqeY motif [89094] (1)

multihelical; consists of two different alpha-helical bundles (4-helical and 3-helical)
- YfbU-like [116959] (1)

multihelical; consist of two subdomains; forms 24-mer with the N-terminal sudbomains packing around the 4-fold axis and the C-terminal domains interacting at the 2-fold and 3-fold axes
- Hypothetical protein MPN330 [116964] (1)

multihelical; consists of three different 4-helical bundles
- HD-domain/PDEase-like [109603] (1)

multihelical; consists of two different alpha-helical bundles
- Superantigen MAM [101343] (1)

multihelical; consists of two different alpha-helical bundles
- Influenza virus matrix protein M1 [48144] (1)

multihelical; consists of two different all-alpha subdomains, 4 helices each
- DNA-glycosylase [48149] (1)

multihelical; consists of two all-alpha domains
- An anticodon-binding domain of class I aminoacyl-tRNA synthetases [48162] (1)

multihelical; consists of two all-alpha domains
- Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) [101352] (1)

multihelical; consists of two all-alpha subdomains
- R1 subunit of ribonucleotide reductase, N-terminal domain [48167] (1)

multihelical consists of two all-alpha subdomains
subdomain 1 (residues 10-100) is a 4-helical bundle
- BEACH domain [81836] (1)

multihelical, complex architecture
- Cryptochrome/photolyase FAD-binding domain [48172] (1)

multihelical; consists of two all-alpha subdomains
- 6-phosphogluconate dehydrogenase C-terminal domain-like [48178] (1)

multihelical; common core is formed around two long antiparallel helices related by (pseudo) twofold symmetry
- Uteroglobin-like [48200] (1)

multihelical
- alpha/alpha toroid [48207] (5)

multihelical; up to seven alpha-hairpins are arranged in closed circular array; there may be sequence similarities between different superfamilies
- Citrate synthase [48255] (1)

multihelical; consists of two all-alpha domains
- Cytochrome P450 [48263] (1)

multihelical
- Flagellar transcriptional activator FlhD [63591] (1)

multihelical; forms intertwined dimer of identical 5-helical subunits
- Ribosomal protein L7/12, oligomerisation (N-terminal) domain [48299] (1)

multihelical; intertwined tetramer
- Class II MHC-associated invariant chain ectoplasmic trimerization domain [48304] (1)

multihelical; intertwined trimer of identical 3-helical subunits
- Aldehyde ferredoxin oxidoreductase, C-terminal domains [48309] (1)

multihelical; consists of two all-alpha domains
- Acid phosphatase/Vanadium-dependent haloperoxidase [48316] (1)

multihelical; core: 5-helical bundle; binds cofactor at the beginning of third helix
- BRCA2 helical domain [81871] (1)

multihelical; contains a 3-helical bundle surrounded by several shorter helices
- BRCA2 tower domain [81877] (1)

multihelical; contains a 3-helical Hin recombinase-like subdomain and two long dimerisation helices
- H-NS histone-like proteins [81274] (1)

multihelical oligomeric protein; structure of whole subunit is not known yet but are probably composed of three different domains
- Sigma2 domain of RNA polymerase sigma factors [88945] (1)

multihelical; consists of a conserved 4-helical core and a variable insert subdomain
- DNA repair protein MutS, domain III [48333] (1)

multihelical; consists of 2 all-alpha subdomains
- Helical scaffold and wing domains of SecA [81885] (1)

multihelical; consists of 2 all-alpha subdomains
- all-alpha NTP pyrophosphatases [101385] (1)

multihelical: dimeric 4-helical bundle surrounded by other helices; oligomerizes further in a tetramer
- Hsp90 co-chaperone CDC37 [101390] (1)

multihelical; consists of 2 all-alpha subdomains connected by a long helix
- Nop domain [89123] (1)

multihelical; array of longer and shorter helices; contains an alpha-hairpin dimerisation subdomain
- YidB-like [140803] (1)

multihelical; three strings of short helices are packed across one longer helix
- Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain [48339] (1)

multihelical; bundle of longer and shorter helices
- A virus capsid protein alpha-helical domain [48344] (1)

multihelical; three-helical bundle in the core is surrounded by non-conserved helices
- P40 nucleoprotein [101398] (1)

multihelical; consists of two subdomains
- Rhabdovirus nucleoprotein-like [140808] (1)

multihelical, consist of two helical domains; each domain contains a buried helix
- GTPase activation domain, GAP [48349] (1)

multihelical
- Ras GEF [48365] (1)

multihelical
- Telomeric repeat binding factor (TRF) dimerisation domain [63599] (1)

multihelical; can be divided into an alpha-alpha superhelix domain and a long alpha-hairpin dimerization domain
- Poly A polymerase C-terminal region-like [81890] (1)

multihelical; can be divided into three subdomains (neck, body and tail)
- alpha-alpha superhelix [48370] (23)

multihelical; 2 (curved) layers: alpha/alpha; right-handed superhelix
- GUN4-like [140868] (1)

multihelical; open array, trapping inside an extended region before the C-terminal helix
- Lipoxigenase [48483] (1)

multihelical
large nearly all-alpha domain
- gene 59 helicase assembly protein [48492] (1)

multihelical; consists of two all-alpha subdomains
- Tetracyclin repressor-like, C-terminal domain [48497] (1)

multihelical; interlocked (homo)dimer
- Skp1 dimerisation domain-like [81384] (1)

multihelical; interlocked heterodimer with F-box proteins
- F-box domain [81385] (1)

multihelical; interlocked heterodimer with the Skp1 dimerisation domain
- Nuclear receptor ligand-binding domain [48507] (1)

multihelical; 3 layers or orthogonally packed helices
- Phospholipase C/P1 nuclease [48536] (1)

multihelical
- ATP-dependent DNA ligase DNA-binding domain [117017] (1)

multihelical; duplication: contains two intertwined structural repeats related by pseudo twofold symmetry
- DNA primase DnaG, C-terminal domain [117022] (1)

multihelical; segment-swapped dimer
- PriB N-terminal domain-like [140913] (1)

multihelical bundle; contains buried central helix; also includes the PriA interface-forming insert subdomain (alpha+beta)
- VPS9 domain [109992] (1)

multihelical; consist of two subdomains
- Triger factor/SurA peptide-binding domain-like [109997] (1)

multihelical; irregular array of long and short helices
- DNA terminal protein [140918] (1)

multihelical, open array; contains the C-terminal four-helical bundle, left-handed superhelix
- Glycolipid transfer protein, GLTP [110003] (1)

multihelical; 2 layers or orthogonally packed helices
- Hypothetical protein MG354 [110008] (1)

multihelical bundle; contains buried central helix
- Duffy binding domain-like [140923] (1)

consist of two subdomains, each containing a three-helical bundle
- Fic-like [140930] (1)

multihelical; one central helix is surrounded by seven helices
- Her-1 [110013] (1)

multihelical; consists of two topologically similar alpha-helical bundles
- ERO1-like [110018] (1)

multihelical; consists of 2 four-helical bundles
- Serum albumin-like [48551] (1)

multihelical; one domain consists of two similar disulfide-linked subdomains
- L-aspartase-like [48556] (1)

multihelical, consists of three all-alpha domains
- Formin homology 2 domain (FH2 domain) [101446] (1)

multihelical, consists of three all-alpha domains
- Terpenoid synthases [48575] (1)