Superfamily: RuvA domain 2-like

duplication: contains two helix-hairpin-helix (HhH) motifs

Lineage:

1. Root: scop
2. Class: All alpha proteins [46456]
3. Fold: SAM domain-like [47768]
   4-5 helices; bundle of two orthogonally packed alpha-hairpins; involved in the interactions with DNA and proteins
4. Superfamily: RuvA domain 2-like [47781]
   duplication: contains two helix-hairpin-helix (HhH) motifs

Families:

1. DNA helicase RuvA subunit, middle domain [47782] (3)
   1. DNA helicase RuvA subunit, middle domain [47783]
      tetramer; binds Holliday junction
      1. Escherichia coli [TaxId: 562] [47784] (5)
      2. Mycobacterium leprae [TaxId: 1769] [47785] (1)
      3. Thermus thermophilus [TaxId: 274] [81794] (1)
2. Excinuclease UvrC C-terminal domain [81795] (1)
   1. Excinuclease UvrC C-terminal domain [81796]
      1. Escherichia coli [TaxId: 562] [81797] (1)
3. NAD+-dependent DNA ligase, domain 3 [47786] (1)
   1. NAD+-dependent DNA ligase, domain 3 [47787]
      duplication: consists of two RuvA-like domains (four HhH motifs); also contains a zinc-finger subdomain
      1. Thermus filiformis [TaxId: 276] [47788] (2)
4. Topoisomerase V repeat domain [140626] (1)
   1. Topoisomerase V [140627]
      1. Methanopyrus kandleri [TaxId: 2320] [140628] (4)
5. Hef domain-like [140629] (4)
   helicase/nuclease domain; forms homo and heterodimers; probably includes the Excinuclease UvrC C-terminal domain (scop_fa 81795, that contains a single NMR structure of a monomeric truncated domain, 1kft)
   1. DNA excision repair protein ERCC-1 [140630]
      1. Human (Homo sapiens) [TaxId: 9606] [140631] (2)
   2. ATP-dependent RNA helicase PF2015 [140632]
      1. Pyrococcus furiosus [TaxId: 2261] [140633] (2)
   3. DNA repair endonuclease XPF [140634]
      1. Aeropyrum pernix [TaxId: 56636] [140635] (6)
      2. Human (Homo sapiens) [TaxId: 9606] [140636] (4)

Generated from scop database 1.73 with scopm 1.101 on Wed Nov 21 11:18:32 2007 Copyright © 1994-2007 The scop authors / scop@mrc-lmb.cam.ac.uk