Family: Hef domain-like

helicase/nuclease domain; forms homo and heterodimers; probably includes the Excinuclease UvrC C-terminal domain (scop_fa 81795, that contains a single NMR structure of a monomeric truncated domain, 1kft)

Lineage:

1. Root: scop
2. Class: All alpha proteins [46456]
3. Fold: SAM domain-like [47768]
   4-5 helices; bundle of two orthogonally packed alpha-hairpins; involved in the interactions with DNA and proteins
4. Superfamily: RuvA domain 2-like [47781]
   duplication: contains two helix-hairpin-helix (HhH) motifs
5. Family: Hef domain-like [140629]
   helicase/nuclease domain; forms homo and heterodimers; probably includes the Excinuclease UvrC C-terminal domain (scop_fa 81795, that contains a single NMR structure of a monomeric truncated domain, 1kft)

Protein Domains:

1. DNA excision repair protein ERCC-1 [140630]
   1. Human (Homo sapiens) [TaxId: 9606] [140631] (2)
2. ATP-dependent RNA helicase PF2015 [140632]
   1. Pyrococcus furiosus [TaxId: 2261] [140633] (2)
3. DNA repair endonuclease XPF [140634]
   1. Aeropyrum pernix [TaxId: 56636] [140635] (6)
   2. Human (Homo sapiens) [TaxId: 9606] [140636] (4)

Generated from scop database 1.73 with scopm 1.101 on Wed Nov 21 11:18:32 2007 Copyright © 1994-2007 The scop authors / scop@mrc-lmb.cam.ac.uk