Class: All beta proteins

Lineage:

1. Root: scop
2. Class: All beta proteins [48724]

Folds:

1. Immunoglobulin-like beta-sandwich [48725] (27)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands
   1. Immunoglobulin [48726] (4)
   2. E set domains [81296] (20)
      "Early" Ig-like fold families possibly related to the immunoglobulin and/or fibronectin type III superfamilies
   3. Fibronectin type III [49265] (1)
   4. PKD domain [49299] (1)
   5. beta-Galactosidase/glucuronidase domain [49303] (1)
   6. Transglutaminase, two C-terminal domains [49309] (1)
   7. Cadherin-like [49313] (2)
   8. Actinoxanthin-like [49319] (1)
   9. Cu,Zn superoxide dismutase-like [49329] (1)
      has additional strand at N-terminus
   10. CBD9-like [49344] (3)
       has additional strand at N-terminus; the active site in a similar topological location as the Cu,Zn SOD site
   11. Lamin A/C globular tail domain [74853] (1)
   12. Clathrin adaptor appendage domain [49348] (3)
       contains an additional N-terminal strand
   13. Integrin domains [69179] (1)
   14. PapD-like [49354] (2)
       contains PP switch between strands D and C'
   15. Purple acid phosphatase, N-terminal domain [49363] (1)
   16. Fungal immunomodulatory protein, FIP [101542] (1)
   17. Superoxide reductase-like [49367] (1)
   18. Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha) [74863] (1)
   19. Invasin/intimin cell-adhesion fragments [49373] (1)
   20. Antigen MPT63/MPB63 (immunoprotective extracellular protein) [81982] (1)
   21. Tp47 lipoprotein, middle and C-terminal domains [81986] (1)
   22. ASF1-like [101546] (1)
       contains extra C-terminal strand
   23. ApaG-like [110069] (1)
   24. Accessory protein X4 (ORF8, ORF7a) [117066] (1)
   25. LEA14-like [117070] (1)
   26. ICP-like [141066] (1)
       topological variant with similarity to the Cupredoxin-like fold (scop_cf 49502) in the N-terminal region
   27. CalX-like [141072] (1)
2. Common fold of diphtheria toxin/transcription factors/cytochrome f [49379] (10)
   sandwich; 9 strands in 2 sheet; greek-key; subclass of immunoglobin-like fold
   1. Diphtheria toxin, C-terminal domain [49380] (1)
   2. Carbohydrate-binding domain [49384] (3)
   3. Bacterial adhesins [49401] (6)
   4. Alpha-macroglobulin receptor domain [49410] (1)
   5. p53-like transcription factors [49417] (7)
   6. Cytochrome f, large domain [49441] (1)
   7. beta-sandwich domain of Sec23/24 [81995] (1)
   8. Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor [49447] (1)
      duplication: one domain of this fold is inserted into another domain of the same fold
   9. Peptidylarginine deiminase Pad4, middle domain [110083] (1)
   10. DR1885-like metal-binding protein [110087] (1)
3. Prealbumin-like [49451] (7)
   sandwich; 7 strands in 2 sheets, greek-key
   variations: some members have additional 1-2 strands to common fold
   1. Starch-binding domain-like [49452] (2)
   2. Carboxypeptidase regulatory domain-like [49464] (2)
   3. VHL [49468] (1)
   4. Transthyretin (synonym: prealbumin) [49472] (1)
   5. Cna protein B-type domain [49478] (1)
   6. Aromatic compound dioxygenase [49482] (1)
   7. Hypothetical protein PA1324 [117074] (1)
4. HSP40/DnaJ peptide-binding domain [49492] (1)
   sandwich; 6 strands in 2 sheets
   1. HSP40/DnaJ peptide-binding domain [49493] (1)
5. Penicillin-binding protein associated domain [69188] (1)
   sandwich; 6 strands in 2 sheets
   1. Penicillin-binding protein associated domain [69189] (2)
6. alpha-Amylase inhibitor tendamistat [49497] (1)
   sandwich; 6 strands in 2 sheets
   1. alpha-Amylase inhibitor tendamistat [49498] (1)
7. C-terminal domain of mollusc hemocyanin [81278] (1)
   six-stranded beta-sandwich, jelly-roll/greek-key topology
   1. C-terminal domain of mollusc hemocyanin [81277] (1)
      analogous to the Ig-like domain of arthropod hemocyanin; similar sequential but different spatial position relative the shared domain
8. HPA-like [141085] (1)
   sandwich, 6 strands in 2 sheets; jelly-roll (truncated); also includes the pending PCSK9 V domain-like superfamily (the C-terminal domains of 2p4e and 2pmw)
   1. Agglutinin HPA-like [141086] (1)
      forms similar trimers to the PCSK9 V domain; strand directions of the subunit beta-sheets are parallel to the three-fold symmetry axis;
9. L21p-like [141090] (1)
   core: sandwich, 6 strands in 2 sheets
   1. L21p-like [141091] (1)
10. Cupredoxin-like [49502] (2)
    sandwich; 7 strands in 2 sheets, greek-key
    variations: some members have additional 1-2 strands
    1. Cupredoxins [49503] (7)
       contains copper-binding site
    2. Major surface antigen p30, SAG1 [74877] (1)
       SS-crosslinked beta-sandwich of distinct geometry but topologically similar to cupredoxins
11. Ctag/Cox11 [110110] (1)
    sandwich; 7 strands in 2 sheets, greek-key; permutation of the immunoglobulin-like fold
    1. Ctag/Cox11 [110111] (1)
12. Atu1913-like [141098] (1)
    sandwich; 7 strands in two sheets, greek-key/jelly-roll; forms segment swapped dimers, swapping is probably facilitated by the helix insertion after strand 3
    1. Atu1913-like [141099] (1)
13. C2 domain-like [49561] (4)
    sandwich; 8 strands in 2 sheets; greek-key
    1. C2 domain (Calcium/lipid-binding domain, CaLB) [49562] (2)
       two constituent families are related by circular permutation
    2. Periplasmic chaperone C-domain [49584] (1)
    3. PHL pollen allergen [49590] (1)
    4. Rab geranylgeranyltransferase alpha-subunit, insert domain [49594] (1)
14. TRAF domain-like [49598] (1)
    sandwich; 8 strands in 2 sheets; greek-key
    1. TRAF domain-like [49599] (2)
       has a circularly permuted immunoglobulin-fold topology with extra strand
15. Neurophysin II [49605] (1)
    sandwich; 8 strands in 2 sheets; meander
    1. Neurophysin II [49606] (1)
       duplication: composed of two structural repeats
16. N-utilization substance G protein NusG, insert domain [82003] (1)
    sandwich; 8 strands in 2 sheets; meander
    1. N-utilization substance G protein NusG, insert domain [82004] (1)
17. Nucleoplasmin-like/VP (viral coat and capsid proteins) [88632] (7)
    sandwich; 8 strands in 2 sheets; jelly-roll; some members can have additional 1-2 strands
    characteristic interaction between the domains of this fold allows the formation of five-fold and pseudo six-fold assemblies
    1. Nucleoplasmin-like core domain [69203] (1)
       oligomerizes into a pentameric ring structure
    2. Positive stranded ssRNA viruses [88633] (9)
    3. ssDNA viruses [88645] (3)
    4. Group I dsDNA viruses [88648] (1)
    5. Group II dsDNA viruses VP [49749] (3)
       duplication: consists of two domains of this fold packed together like the nucleoplasmin subunits
       trimeric; in the trimers, the domains are arranged around pseudo six-fold axis
    6. Satellite viruses [88650] (1)
    7. PHM/PNGase F [49742] (2)
       members of this superfamily bind peptide substrates
       duplication: consists of two domains of this fold packed together like the adjacent nucleoplasmin subunits
18. gamma-Crystallin-like [49694] (1)
    sandwich; 8 strands in 2 sheets; greek-key
    duplication: has internal pseudo twofold symmetry
    1. gamma-Crystallin-like [49695] (6)
19. Lipase/lipooxygenase domain (PLAT/LH2 domain) [49722] (1)
    sandwich; 8 strands in 2 sheets; complex topology
    duplication: has weak internal pseudo twofold symmetry
    1. Lipase/lipooxygenase domain (PLAT/LH2 domain) [49723] (3)
20. Calpain large subunit, middle domain (domain III) [49757] (1)
    sandwich; 8 strands in 2 sheets; jelly-roll
    1. Calpain large subunit, middle domain (domain III) [49758] (1)
21. Supernatant protein factor (SPF), C-terminal domain [101575] (1)
    sandwich; 8 strands in 2 sheets; jelly-roll; similarity to the Nucleoplasmin-like/VP fold
    1. Supernatant protein factor (SPF), C-terminal domain [101576] (1)
22. Hypothetical protein TM1070 [89231] (1)
    sandwich; 8 strands in 2 sheets; jelly-roll
    1. Hypothetical protein TM1070 [89232] (1)
23. Olfactory marker protein [63696] (1)
    sandwich; 8 strands in 2 sheets; jelly-roll
    1. Olfactory marker protein [63697] (1)
24. HSP20-like chaperones [49763] (1)
    sandwich; 8 strands in 2 sheets; greek-key
    1. HSP20-like chaperones [49764] (4)
25. Heat shock protein 70kD (HSP70), peptide-binding domain [100919] (1)
    beta-sandwich: 8 strands in 2 sheets
    1. Heat shock protein 70kD (HSP70), peptide-binding domain [100920] (1)
26. Ecotin, trypsin inhibitor [49771] (1)
    sandwich; 8 strands in 2 sheets; complex topology with the crossing loops
    1. Ecotin, trypsin inhibitor [49772] (1)
27. PEBP-like [49776] (1)
    sandwich; 8 strands in 2 sheets; greek-key: partial topological similarity to immunoglobulin-like folds
    1. PEBP-like [49777] (2)
28. Ganglioside M2 (gm2) activator [63706] (1)
    sandwich; 8 strands in 2 sheets; greek-key: partial topological similarity to immunoglobulin-like folds
    1. Ganglioside M2 (gm2) activator [63707] (1)
29. Nicotinic receptor ligand binding domain-like [63711] (1)
    sandwich; 8 strands in 2 sheets; greek-key: partial topological similarity to immunoglobulin-like folds
    1. Nicotinic receptor ligand binding domain-like [63712] (1)
30. Beta-galactosidase LacA, domain 3 [117099] (1)
    sandwich; 8 strands in 2 sheets
    1. Beta-galactosidase LacA, domain 3 [117100] (1)
31. Galactose-binding domain-like [49784] (1)
    sandwich; 9 strands in 2 sheets; jelly-roll
    1. Galactose-binding domain-like [49785] (30)
32. Viral protein domain [49817] (1)
    sandwich; 9 strands in 2 sheets; jelly-roll; form trimers
    1. Viral protein domain [49818] (3)
       forms homotrimers
33. Calcium-mediated lectin [82025] (1)
    sandwich; 9 strands in 2 sheets; greek-key
    1. Calcium-mediated lectin [82026] (1)
34. Dextranase, N-terminal domain [101595] (1)
    sandwich; 9 strands in 2 sheets; greek-key
    1. Dextranase, N-terminal domain [101596] (1)
35. Unnamed hypothetical protein [101600] (1)
    sandwich; 9 strands in 2 sheets; greek-key/jelly-roll
    1. Unnamed hypothetical protein [101601] (1)
36. Superantigen (mitogen) Ypm [101605] (1)
    sandwich; 9 strands in 2 sheets; jelly-roll
    1. Superantigen (mitogen) Ypm [101606] (1)
37. ENV polyprotein, receptor-binding domain [49829] (1)
    sandwich; 9 strands in 2 sheets; greek-key; contains a few helices in loop regions
    1. ENV polyprotein, receptor-binding domain [49830] (1)
38. BTV NS2-like ssRNA-binding domain [110131] (1)
    sandwich; 9 strands in 2 sheets; unusual topology with 2 crossover loops
    1. BTV NS2-like ssRNA-binding domain [110132] (1)
39. Virus attachment protein globular domain [49834] (1)
    sandwich, 10 strands in 2 sheets; greek-key
    1. Virus attachment protein globular domain [49835] (3)
40. TNF-like [49841] (1)
    sandwich, 10 strands in 2 sheets; jelly-roll
    1. TNF-like [49842] (1)
41. CUB-like [49853] (3)
    sandwich, 10 strands in 2 sheets; jelly-roll
    1. Spermadhesin, CUB domain [49854] (1)
    2. Collagen-binding domain [89260] (1)
       N-terminal strand appears only in calcium-free form
    3. Acetamidase/Formamidase-like [141130] (1)
       decorated fold with additional structures; contains extra C-terminal alpha+beta subdomain: beta(2)-alpha(2)-beta(2): antiparallel beta-sheet, order 1243
42. Hyaluronate lyase-like, C-terminal domain [49862] (1)
    sandwich, 10 strands in 2 sheets; "folded meander"
    1. Hyaluronate lyase-like, C-terminal domain [49863] (1)
43. Cytolysin/lectin [63723] (1)
    sandwich, 10 strands in 2 sheets;
    1. Cytolysin/lectin [63724] (2)
       some topological similarity to osmotin
44. Putative glucosidase YicI, C-terminal domain [117124] (1)
    sandwich; 10 strands in two sheets
    1. Putative glucosidase YicI, C-terminal domain [117125] (1)
45. CsrA-like [117129] (1)
    sandwich; 10 strands in 2 sheets; intertwined dimer (segment-swapped, 5-stranded greek-key sandwich?)
    1. CsrA-like [117130] (1)
46. Osmotin, thaumatin-like protein [49869] (1)
    sandwich; 11 strands in 2 sheets
    1. Osmotin, thaumatin-like protein [49870] (1)
       has two smaller insertion domains
47. SMAD/FHA domain [49878] (1)
    sandwich; 11 strands in 2 sheets; greek-key
    1. SMAD/FHA domain [49879] (4)
       has a few short helices inserted in loops
48. Soluble secreted chemokine inhibitor, VCCI [49888] (1)
    sandwich; 11 strands in 2 sheets; greek-key
    1. Soluble secreted chemokine inhibitor, VCCI [49889] (1)
49. Baculovirus p35 protein [49893] (1)
    sandwich; 14 strands in 2 sheets; greek-key
    1. Baculovirus p35 protein [49894] (1)
       has a few helices inserted in loops
50. Concanavalin A-like lectins/glucanases [49898] (1)
    sandwich; 12-14 strands in 2 sheets; complex topology
    1. Concanavalin A-like lectins/glucanases [49899] (25)
51. Supersandwich [49993] (3)
    sandwich; 18 strands in 2 sheets
    1. Galactose mutarotase-like [74650] (11)
       probable carbohydrate-binding domain in enzymes acting on sugars
    2. V-region of surface antigen I/II (SA I/II, PAC) [74914] (1)
    3. Amine oxidase catalytic domain [49998] (1)
52. Leukotriene A4 hydrolase N-terminal domain [63736] (1)
    duplication: two beta-sandwiches of similar topologies are fused together in a single three beta-sheet domain
    1. Leukotriene A4 hydrolase N-terminal domain [63737] (1)
53. EV matrix protein [50011] (1)
    consists of two beta-sandwich domains of similar topologies
    1. EV matrix protein [50012] (1)
54. Viral chemokine binding protein m3 [82045] (1)
    consists of two different beta-sandwich domains of partial topological similarity to immunoglobulin-like folds
    1. Viral chemokine binding protein m3 [82046] (1)
55. gp9 [50016] (1)
    consists of two different beta-sandwich domains unrelated to other beta-sandwich folds
    1. gp9 [50017] (1)
56. Flagellar hook protein flgE [117142] (1)
    consists of two different domains; d1: [complex fold made of bifurcated beta-sheets]; d2 (inserted into d1): [beta-sandwich; 8 strands in 2 sheets]
    1. Flagellar hook protein flgE [117143] (1)
57. ISP domain [50021] (1)
    consists of two all-beta subdomains: conserved small domain has a rubredoxin-like fold; larger domain consists of 6 beta-stands packed in either sandwich of two 3-stranded sheets or closed barrel (n=6; S=8)
    1. ISP domain [50022] (2)
58. Obg-fold [82050] (1)
    this fold is formed by three glycine-rich regions inserted into a small 8-stranded beta-sandwich
    these regions form six left-handed collagen-like helices packed and H-bonded together
    1. Obg GTP-binding protein N-terminal domain [82051] (1)
59. SH3-like barrel [50036] (18)
    barrel, partly opened; n*=4, S*=8; meander
    the last strand is interrupted by a turn of 3-10 helix
    1. C-terminal domain of transcriptional repressors [50037] (3)
       the N-terminal domains of these repressors bind DNA
    2. SH3-domain [50044] (1)
    3. Prokaryotic SH3-related domain [82057] (4)
    4. Myosin S1 fragment, N-terminal domain [50084] (1)
    5. Tudor/PWWP/MBT [63748] (3)
    6. Chromo domain-like [54160] (3)
       SH3-like barrel is capped by a C-terminal helix
    7. BAH domain [82061] (1)
    8. PAZ domain [101690] (1)
    9. Cap-Gly domain [74924] (1)
    10. Electron transport accessory proteins [50090] (4)
    11. Translation proteins SH3-like domain [50104] (6)
        many known members contain KOW motif
    12. Cell growth inhibitor/plasmid maintenance toxic component [50118] (3)
        contains insert beta-sheet subdomain and C-terminal helix
    13. Fumarylacetoacetate hydrolase, FAH, N-terminal domain [63433] (1)
    14. DNA-binding domain of retroviral integrase [50122] (1)
    15. Hypothetical protein YfhH [101697] (1)
        contains extra N-terminal all-alpha subdomain
    16. Kinase-associated protein B-like [141251] (1)
        contains extra C-terminal alpha-hairpin
    17. YccV-like [141255] (1)
        contains extra C-terminal helix packed against barrel
    18. CarD-like [141259] (1)
60. GroES-like [50128] (2)
    contains barrel, partly opened; n*=4, S*=8; meander
    1. GroES-like [50129] (2)
    2. SacY-like RNA-binding domain [50151] (1)
61. PDZ domain-like [50155] (1)
    contains barrel, partly opened; n*=4, S*=8; meander; capped by alpha-helix
    1. PDZ domain-like [50156] (4)
       peptide-binding domain
62. N-terminal domains of the minor coat protein g3p [50175] (1)
    core: barrel, in some members open; n*=4, S*=8; meander
    1. N-terminal domains of the minor coat protein g3p [50176] (1)
63. Sm-like fold [50181] (3)
    core: barrel, open; n*=4, S*=8; meander; SH3-like topology
    1. Sm-like ribonucleoproteins [50182] (5)
    2. YhbC-like, C-terminal domain [74942] (1)
    3. GatD N-terminal domain-like [141300] (1)
64. Stringent starvation protein B, SspB [101737] (1)
    core: barrel, open; n*=4, S*=8; meander; SH3-like topology; some similarity to the Sm-like fold
    1. Stringent starvation protein B, SspB [101738] (1)
65. Rof/RNase P subunit-like [101743] (1)
    core: barrel, open; n*=4, S*=8; meander; SH3-like topology; some similarity to the Sm-like fold
    1. Rof/RNase P subunit-like [101744] (2)
66. Hydrophobin II, HfbII [101750] (1)
    core: barrel, closed; n=4, S=8; complex topology; helix-containing crossover connection
    1. Hydrophobin II, HfbII [101751] (1)
67. Ribosomal protein L14 [50192] (1)
    barrel, closed; n=5, S=8, meander
    1. Ribosomal protein L14 [50193] (1)
68. OB-fold [50198] (12)
    barrel, closed or partly opened n=5, S=10 or S=8; greek-key
    1. Staphylococcal nuclease [50199] (1)
    2. Bacterial enterotoxins [50203] (2)
    3. TIMP-like [50242] (3)
    4. Heme chaperone CcmE [82093] (1)
    5. Tail-associated lysozyme gp5, N-terminal domain [69255] (1)
    6. Hypothetical protein YgiW [101756] (1)
    7. Nucleic acid-binding proteins [50249] (14)
    8. Inorganic pyrophosphatase [50324] (1)
    9. MOP-like [50331] (3)
    10. CheW-like [50341] (1)
    11. TM0957-like [141318] (1)
        extra N-terminal region and large insertion after strand 3 together form an alpha-helical subdomain
    12. NfeD domain-like [141322] (1)
        close structural similarity to some members of the Nucleic acid-binding OB-fold proteins, possibly related to this superfamily
69. PRC-barrel domain [50345] (1)
    core: barrel, partly opened; n*=5, S*=8; meander
    1. PRC-barrel domain [50346] (4)
70. beta-Trefoil [50352] (8)
    barrel, closed; n=6, S=12; and a hairpin triplet; meander
    duplication: has internal pseudo threefold symmetry
    1. Cytokine [50353] (2)
    2. MIR domain [82109] (1)
    3. Ricin B-like lectins [50370] (3)
    4. Agglutinin [50382] (1)
       this superfamily is distinct from the ricin B-like lectin superfamily
    5. STI-like [50386] (2)
    6. Actin-crosslinking proteins [50405] (2)
    7. DNA-binding protein LAG-1 (CSL) [110217] (1)
       contains rudiment hairpin triplet lacking one hairpin
    8. AbfB domain [110221] (1)
71. Reductase/isomerase/elongation factor common domain [50412] (4)
    barrel, closed; n=6, S=10; greek-key
    1. Riboflavin synthase domain-like [63380] (3)
    2. Riboflavin kinase-like [82114] (1)
    3. FucI/AraA C-terminal domain-like [50443] (2)
    4. Translation proteins [50447] (5)
72. Elongation factor/aminomethyltransferase common domain [50464] (2)
    barrel, closed; n=6, S=10; greek-key
    1. EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain [50465] (1)
       probably related to the second domain and its superfamiy by a circular permutation
    2. Aminomethyltransferase beta-barrel domain [101790] (1)
73. Split barrel-like [50474] (2)
    barrel; n=6, S=10; greek-key
    1. FMN-binding split barrel [50475] (3)
       related to the ferredoxin reductase-like FAD-binding domain
    2. PilZ domain-like [141371] (2)
74. Phage tail proteins [69278] (1)
    core: barrel; n=6, S=10; greek-key; topologically similar to the FMN-binding split barrel
    1. Phage tail proteins [69279] (2)
75. Surface presentation of antigens (SPOA) [101800] (1)
    segment-swapped dimer forming two identical conjoint barrels (n=6, S=10) topologically similar to the FMN-binding split barrel
    1. Surface presentation of antigens (SPOA) [101801] (1)
76. FMT C-terminal domain-like [50485] (1)
    barrel, open; n*=6, S*=10; greek-key
    1. FMT C-terminal domain-like [50486] (2)
77. Trypsin-like serine proteases [50493] (1)
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
    1. Trypsin-like serine proteases [50494] (4)
78. Replicase NSP9 [101815] (1)
    barrel; n=6, S=8, greek-key; similar to one trypsin-like protease barrel
    1. Replicase NSP9 [101816] (1)
79. mu transposase, C-terminal domain [50609] (1)
    barrel; n=6, S=8, greek-key
    1. mu transposase, C-terminal domain [50610] (1)
80. Domain of alpha and beta subunits of F1 ATP synthase-like [50614] (3)
    barrel, closed; n=6, S=8; greek-key
    1. N-terminal domain of alpha and beta subunits of F1 ATP synthase [50615] (1)
    2. Alanine racemase C-terminal domain-like [50621] (2)
       the barrel is decorated with additional structures
    3. Aminopeptidase/glucanase lid domain [101821] (1)
81. Small protein B (SmpB) [74981] (1)
    barrel, closed; n=6, S=8, greek-key, partial similarity to the OB-fold
    1. Small protein B (SmpB) [74982] (1)
82. Acid proteases [50629] (1)
    barrel, closed; n=6, S=10, complex topology
    1. Acid proteases [50630] (2)
83. ValRS/IleRS/LeuRS editing domain [50676] (1)
    core: barrel, closed; n=6, S=8; topology is similar to that of the acid proteases barrel
    1. ValRS/IleRS/LeuRS editing domain [50677] (1)
84. Urease metallochaperone UreE, N-terminal domain [69286] (1)
    barrel, closed; n=6, S=8; a crossover loop topology
    1. Urease metallochaperone UreE, N-terminal domain [69287] (1)
85. Double psi beta-barrel [50684] (2)
    barrel, closed; n=6, S=10; complex topology with crossover (psi) loops
    1. Barwin-like endoglucanases [50685] (3)
    2. ADC-like [50692] (3)
86. Ribosomal protein L25-like [50714] (1)
    barrel, closed; n=6, S=10; complex topology
    1. Ribosomal protein L25-like [50715] (2)
87. Core binding factor beta, CBF [50722] (1)
    barrel, closed; n=6, S=10; meander; capped at both ends by alpha-helices
    1. Core binding factor beta, CBF [50723] (1)
88. PH domain-like barrel [50728] (2)
    barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix
    1. PH domain-like [50729] (12)
    2. PA2021-like [141447] (1)
       prokaryotiic proteins of PH domain-like fold lacking the N-terminal strand
89. Transcription factor IIA (TFIIA), beta-barrel domain [50783] (1)
    barrel, closed; n=6, S=12; mixed beta-sheet
    1. Transcription factor IIA (TFIIA), beta-barrel domain [50784] (1)
       dimer of non-identical beta-sheet domains
90. Hcp1-like [141451] (1)
    barrel, closed; n=6, S=12; contains extra, non-barrel strand 7 at the C-terminus
    1. Hcp1-like [141452] (1)
       probable biological unit is a ring-like hexamer containing a 24-stranded beta-barrel made of the subunit beta-sheets
91. Herpes virus serine proteinase, assemblin [50788] (1)
    core: barrel, closed; n=7, S=8; complex topology
    1. Herpes virus serine proteinase, assemblin [50789] (1)
92. PK beta-barrel domain-like [50799] (1)
    barrel, closed; n=7, S=10; complex topology
    1. PK beta-barrel domain-like [50800] (2)
93. XRCC4, N-terminal domain [50808] (1)
    barrel, closed; n=7, S=10; order: 1234765; strands 1 and 5 are parallel to each other
    1. XRCC4, N-terminal domain [50809] (1)
       an HTH motif connects strands 4 and 5
94. HesB-like domain [89359] (1)
    barrel, closed; n=7, S=10; complex topology
    1. HesB-like domain [89360] (1)
95. Bacterial fluorinating enzyme, C-terminal domain [101851] (1)
    barrel, closed; n=7, S=10; greek-key topology; one overside connection
    1. Bacterial fluorinating enzyme, C-terminal domain [101852] (1)
96. SPOC domain-like [100938] (1)
    barrel, closed; n=7, S=10; complex topology
    1. SPOC domain-like [100939] (3)
97. BH3618-like [141456] (1)
    barrel, closed; n=7, S=10; meander
    1. BH3618-like [141457] (1)
98. FAS1 domain [82152] (1)
    core: barrel, closed; n=7, S=12; meander
    1. FAS1 domain [82153] (1)
99. Lipocalins [50813] (1)
    barrel, closed or opened; n=8, S=12; meander
    1. Lipocalins [50814] (8)
       bind hydrophobic ligands in their interior
100. Streptavidin-like [50875] (8)
     barrel, closed; n=8, S=10; meander
     1. Avidin/streptavidin [50876] (1)
     2. beta-Barrel protease inhibitors [50882] (2)
     3. D-aminopeptidase, middle and C-terminal domains [50886] (1)
     4. Quinohemoprotein amine dehydrogenase A chain, domain 3 [69298] (1)
     5. Dipeptidyl peptidase I (cathepsin C), exclusion domain [75001] (1)
     6. YceI-like [101874] (1)
     7. Extracellular hemoglobin linker subunit, receptor domain [141480] (1)
     8. YdhA-like [141488] (1)
101. Allene oxide cyclase-like [141492] (1)
     barrel, closed; n=8, S=10; meander; mirrored (reversed) topology to the Spreptavidin-like and Lipocalin-like folds
     1. Allene oxide cyclase-like [141493] (1)
102. Cyclophilin-like [50890] (1)
     barrel, closed; n=8, S=10; complex topology