Protein: Immunoglobulin light chain lambda variable domain, VL-lambda from Human (Homo sapiens), cluster 2 [TaxId: 9606]

Lineage:

1. Root: scop
2. Class: All beta proteins [48724]
3. Fold: Immunoglobulin-like beta-sandwich [48725]
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands
4. Superfamily: Immunoglobulin [48726]
5. Family: V set domains (antibody variable domain-like) [48727]
6. Protein: Immunoglobulin light chain lambda variable domain, VL-lambda [88534]
   VL-lambda domains of human antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the human genome; mouse VL-lambda domains belong to a single germline family
7. Species: Human (Homo sapiens), cluster 2 [TaxId: 9606] [88536]

PDB Entry Domains:

1. 2rhe
   VL of Bence-Jones protein RHE
   1. chain a [20523]
2. 1rzf
   part of anti HIV-1 gp120-reactive Fab E51
   complexed with gol, ioh
   1. region l:2-108 [98152]
3. 2fb4
   part of Fab KOL
   1. region l:1-109 [19846]
4. 1nl0
   part of Fab 10c12 against factor IX Gla domain
   complexed with ca, so4
   1. region l:1-108 [91947]
5. 1bjm
   VL dimer of Bence-Jones protein LOC
   1. region a:1-111 [20524]
   2. region b:1-111 [20525]
6. 3bjl
   VL dimer of Bence-Jones protein LOC
   1. region a:1-111 [20526]
   2. region b:1-111 [20527]
7. 4bjl
   VL dimer of Bence-Jones protein LOC
   1. region a:2-111 [20528]
   2. region b:2-111 [20529]
8. 1q1j
   part of anti HIV-1 Fab 447-52d
   1. region l:1-108 [95585]
   2. region m:1-108 [95587]
9. 2ig2
   part of antibody KOL; intact protein but only Fab's can be seen in the crystal structure
   1. region l:1-109 [19848]

Generated from scop database 1.73 with scopm 1.101 on Wed Nov 21 11:18:32 2007 Copyright © 1994-2007 The scop authors / scop@mrc-lmb.cam.ac.uk