Protein: Immunoglobulin heavy chain variable domain, VH from Human (Homo sapiens), cluster 1 [TaxId: 9606]

Lineage:

1. Root: scop
2. Class: All beta proteins [48724]
3. Fold: Immunoglobulin-like beta-sandwich [48725]
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands
4. Superfamily: Immunoglobulin [48726]
5. Family: V set domains (antibody variable domain-like) [48727]
6. Protein: Immunoglobulin heavy chain variable domain, VH [88543]
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species
7. Species: Human (Homo sapiens), cluster 1 [TaxId: 9606] [88544]

PDB Entry Domains:

1. 1rzf
   part of anti HIV-1 gp120-reactive Fab E51
   complexed with gol, ioh
   1. region h:2-113 [98150]
2. 2fx7
   automatically matched to d1hzhh1
   complexed with gol; mutant
   1. region h:1-113 [134276]
3. 1n0x
   part of an anti HIV-1 Fab
   complexed with cxs, gol, k, orn, so4
   1. region h:1-113 [91528]
   2. region k:1-113 [91530]
4. 2nxy
   automatically matched to d1rz8b1
   complexed with hez, nag, trs; mutant
   1. region d:3001-3128 [138749]
5. 1rz7
   part of anti HIV-1 gp120-reactive Fab 48D
   complexed with gol
   1. region h:1-113 [98133]
6. 1rzg
   part of anti HIV-1 gp120-reactive Fab 412D
   complexed with suc
   1. region a:1-113 [98154]
   2. region c:2-113 [98158]
7. 2ny2
   automatically matched to d1rz8b1
   complexed with edo, hez, nag, suc; mutant
   1. region d:3001-3128 [138774]
8. 1iqd
   part of intact IgG B12 antibody
   mutant
   1. region b:1-114 [62646]
9. 1vge
   part of humanized Fab TR1.9
   1. region h:1-122 [20095]
10. 2ny3
    automatically matched to d1rz8b1
    complexed with nag, suc; mutant
    1. region d:3001-3128 [138780]
11. 2ny4
    automatically matched to d1rz8b1
    complexed with hez, nag, suc; mutant
    1. region d:3001-3128 [138786]
12. 1rhh
    part of HIV-1 neutralizing Fab x5
    1. region b:3-113 [97475]
    2. region d:4-113 [97479]
13. 2ny1
    automatically matched to d1rz8b1
    complexed with nag, suc; mutant
    1. region d:3001-3128 [138768]
14. 2nxz
    automatically matched to d1rz8b1
    complexed with edo, hez, ipa, nag, suc; mutant
    1. region d:3001-3128 [138755]
15. 2fx9
    automatically matched to d1hzhh1
    complexed with orq
    1. region h:1-113 [134296]
16. 2fx9
    automatically matched to d1hzhh1
    complexed with orq
    1. region i:1-113 [134298]
17. 1tzg
    automatically matched to d1hzhh1
    complexed with gol
    1. region h:1-113 [119396]
18. 1tzg
    automatically matched to d1hzhh1
    complexed with gol
    1. region i:1-113 [119398]
19. 2ny0
    automatically matched to d1rz8b1
    complexed with hez, nag; mutant
    1. region d:3001-3128 [138762]
20. 2fx8
    automatically matched to d1hzhh1
    mutant
    1. region h:1-113 [134280]
21. 2fx8
    automatically matched to d1hzhh1
    mutant
    1. region i:1-113 [134282]
22. 2fx8
    automatically matched to d1hzhh1
    mutant
    1. region j:1-113 [134284]
23. 2fx8
    automatically matched to d1hzhh1
    mutant
    1. region k:1-113 [134286]
24. 1yym
    automatically matched to d1rz8b1
    complexed with edo, ipa, mpt, nag, ndg, vlm; mutant
    1. region h:1-113 [124233]
25. 1yym
    automatically matched to d1rz8b1
    complexed with edo, ipa, mpt, nag, ndg, vlm; mutant
    1. region r:1001-1113 [124240]
26. 2ny7
    automatically matched to d1hzhh1
    complexed with nag; mutant
    1. region h:1-113 [138800]
27. 1rz8
    part of anti HIV-1 gp120-reactive Fab 17B
    1. region b:1-113 [98139]
    2. region d:1-113 [98143]
28. 2i60
    automatically matched to d1rz8b1
    complexed with ipa, mpt, nag, ndg, vlm
    1. region h:2-113 [137082]
29. 2i60
    automatically matched to d1rz8b1
    complexed with ipa, mpt, nag, ndg, vlm
    1. region r:1-113 [137089]
30. 2ny5
    automatically matched to d1rz8b1
    complexed with nag, suc; mutant
    1. region h:3001-3128 [138790]
31. 1g9m
    part of HIV-1 neutralizing Fab 17B; binds to the CD4-induced state of gp120
    complexed with fuc, ioh, nag; mutant
    1. region h:1-129 [20263]
32. 1rzj
    part of anti HIV-1 gp120-reactive Fab 17B
    complexed with fuc, ioh, nag; mutant
    1. region h:1-113 [98201]
33. 1gc1
    part of HIV-1 neutralizing Fab 17B; binds to the CD4-induced state of gp120
    complexed with fuc, nag; mutant
    1. region h:1-129 [20265]
34. 1yyl
    automatically matched to d1rz8b1
    complexed with bif, mpt, nag, ndg, vlm; mutant
    1. region h:1-113 [124223]
35. 1yyl
    automatically matched to d1rz8b1
    complexed with bif, mpt, nag, ndg, vlm; mutant
    1. region r:1001-1113 [124230]
36. 2ny6
    automatically matched to d1rz8b1
    complexed with nag, suc; mutant
    1. region d:3001-3128 [138798]
37. 2i5y
    automatically matched to d1rz8b1
    complexed with bif, mpt, nag, ndg, vlm
    1. region h:1-113 [137072]
38. 2i5y
    automatically matched to d1rz8b1
    complexed with bif, mpt, nag, ndg, vlm
    1. region r:1-113 [137079]
39. 1hzh
    part of intact IgG B12 antibody
    complexed with fuc, gal, man, nag
    1. region h:1-113 [61437]
    2. region k:1-113 [61441]
40. 1rzk
    part of anti HIV-1 gp120-reactive Fab 17B
    complexed with nag; mutant
    1. region h:1-113 [98208]
41. 1g9n
    part of HIV-1 neutralizing Fab 17B; binds to the CD4-induced state of gp120
    complexed with nag; mutant
    1. region h:1-129 [20267]
42. 1rzi
    part of anti HIV-1 gp120-reactive Fab 47E
    1. region b:1-113 [98168]
    2. region d:1-113 [98172]
    3. region f:1-113 [98176]
    4. region h:1-113 [98180]
    5. region j:1-113 [98184]
    6. region l:1-113 [98188]
    7. region n:1-113 [98192]
    8. region p:1-113 [98196]

Generated from scop database 1.73 with scopm 1.101 on Wed Nov 21 11:18:32 2007 Copyright © 1994-2007 The scop authors / scop@mrc-lmb.cam.ac.uk