Protein: Immunoglobulin heavy chain variable domain, VH from Mouse (Mus musculus), cluster 2.2 [TaxId: 10090]

Lineage:

1. Root: scop
2. Class: All beta proteins [48724]
3. Fold: Immunoglobulin-like beta-sandwich [48725]
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands
4. Superfamily: Immunoglobulin [48726]
5. Family: V set domains (antibody variable domain-like) [48727]
6. Protein: Immunoglobulin heavy chain variable domain, VH [88543]
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species
7. Species: Mouse (Mus musculus), cluster 2.2 [TaxId: 10090] [88550]

PDB Entry Domains:

1. 1mqk
   part of Fv against Paracoccus denitrificans cytochrome c oxidase
   1. chain h [85053]
2. 1i8k
   part of dsFv MR1; complex with a EGFR-VIII peptide
   mutant
   1. chain b [71131]
3. 2hff
   automatically matched to d1mf2h1
   1. region b:1-113 [136379]
4. 2hff
   automatically matched to d1mf2h1
   1. region h:1-113 [136381]
5. 1qkz
   part of Fab MN14C11.6
   1. region h:1-113 [20137]
6. 1bm3
   part of anti-integrin Fab OPG2
   1. region h:1-125 [20067]
7. 1hil
   part of Fab 17/9
   1. region b:1-112 [19787]
   2. region d:1-112 [19789]
8. 2fbj
   part of Fab J539
   complexed with fuc, nag, zn
   1. region h:1-118 [19851]
9. 1opg
   part of anti-integrin Fab OPG2
   1. region h:1-125 [20069]
10. 1cfv
    part of Fv 4155
    complexed with e3g, zn
    1. chain h [20161]
11. 1h0d
    part of anti-angiogenin FAB; conflict: annotated in PDB as human
    complexed with gol, pca, so4
    1. region b:1-113 [83427]
12. 1dsf
    part of anticancer Fv B1; disulfide-stabilized
    mutant
    1. chain h [20247]
13. 1bfv
    part of Fv 4155
    complexed with stg, zn
    1. chain h [20163]
14. 1i8i
    part of dsFv MR1; complex with a EGFR-VIII peptide
    mutant
    1. chain b [71129]
15. 2hrp
    part of Fab F11.2.32 against HIV-1 protease
    1. region h:1-113 [20171]
    2. region n:1-113 [20173]
16. 1f4x
    part of anti-carbohydrate Fab S-20-4
    complexed with mgs
    1. region h:1-117 [20451]
17. 1ikf
    part of an anti-cyclosporin A Fab
    complexed with aba
    1. region h:1-126 [20033]
18. 1ind
    part of Fab Cha255
    complexed with eot, in
    1. region h:1-114 [19839]
19. 2bfv
    part of Fv 4155
    complexed with stg
    1. chain h [20165]
20. 1f4w
    part of anti-carbohydrate Fab S-20-4
    1. region h:1-117 [20453]
21. 1bz7
    part of humanized Fab R24 from murine ascites
    1. region b:1-122 [20403]
22. 2h1p
    part of polysaccharide binding antibody 2H1
    1. region h:301-420 [20191]
23. 1ejo
    part of anti-FMDV Fab 4C4
    1. region h:2501-2619 [20429]
24. 1ucb
    part of humanized Fab CBR96
    complexed with so4
    1. region h:1-113 [20101]
25. 2hfg
    automatically matched to d1mf2h1
    mutant
    1. region h:1-113 [136383]
26. 1mf2
    part of Fab F11.2.32 against HIV-1 protease
    1. region h:1-113 [20175]
    2. region n:1-113 [20177]
27. 1ifh
    part of Fab 17/9
    1. region h:1-112 [19791]
28. 1frg
    part of Fab 26/9
    complexed with nh2
    1. region h:218-336 [19925]
29. 1ar1
    part of Fv against Paracoccus denitrificans cytochrome c oxidase
    complexed with ca, cu, hea, lda, mg
    1. chain c [20207]
30. 1igc
    part of Fab MoPC21
    1. region h:1-119 [20047]
31. 1cly
    part of humanized Fab CBR96
    complexed with fuc, gal, nag, non
    1. region h:1-113 [20103]
32. 1ine
    part of Fab Cha255
    complexed with eot, fe
    1. region h:1-114 [19841]
33. 1bln
    part of anti-P-glycoprotein Fab MRK-16
    1. region b:1-113 [20331]
    2. region d:1-113 [20333]
34. 1igf
    part of Fab B13I2
    complexed with nag
    1. region h:1-113 [19813]
    2. region j:1-113 [19815]
35. 1clz
    part of Fab MBR96
    complexed with fuc, gal, nag, non
    1. region h:1-113 [20105]
36. 1igt
    part of intact IgG2a antibody Mab231
    complexed with fuc, gal, man, nag
    1. region b:1-114 [19765]
    2. region d:1-114 [19767]
37. 1fh5
    part of Fab MAK33; conflict: annotated in PDB as human protein
    1. region h:4-120 [20465]
38. 1h3p
    part of anti-hepatitis B Fab (against PRES1 region)
    1. region h:1-113 [76648]
39. 1ots
    part of anti-CLC chloride channel Fab
    complexed with cl
    1. region c:2-121 [87417]
    2. region e:2-121 [87421]
40. 1him
    part of Fab 17/9; chain identifiers are mixed up
    complexed with nh2
    1. region l:1-112 [19792]
    2. region m:1-112 [19794]
41. 2igf
    part of Fab B13I2
    complexed with nag
    1. region h:1-113 [19817]
42. 1qle
    part of Fv against Paracoccus denitrificans cytochrome c oxidase
    1. chain h [20209]
43. 1f4y
    part of anti-carbohydrate Fab S-20-4
    complexed with mgu
    1. region h:1-117 [20455]
44. 1hin
    part of Fab 17/9
    1. region h:1-112 [19797]
45. 1kno
    part of Fab CNJ206
    complexed with pnp, zn
    1. region b:1-119 [20009]
    2. region d:1-119 [20011]
    3. region f:1-119 [20013]
46. 1ott
    part of anti-CLC chloride channel Fab
    complexed with cl; mutant
    1. region c:2-121 [87427]
    2. region e:2-121 [87431]
47. 1qfw
    part of anti-[gonadotropin beta subunit] Fv
    complexed with nag
    1. chain i [20437]
48. 1r24
    part of humanized Fab R24 from murine ascites
    1. region b:1-122 [20405]
    2. region d:1-122 [20407]
49. 1otu
    part of anti-CLC chloride channel Fab
    complexed with cl; mutant
    1. region c:2-121 [87437]
    2. region e:2-121 [87441]
50. 1uz8
    MQ P01811 P22436 # ! natural chimera
    complexed with fuc, gal, mag
    1. region b:1-113 [108168]
    2. region h:1-113 [108170]
51. 1uz6
    MQ P01811 P22436 # ! natural chimera
    complexed with so4
    1. region f:1-113 [108152]
    2. region h:1-113 [108154]
    3. region p:1-113 [108160]
    4. region w:1-113 [108164]
52. 2gfb
    part of Fab CNJ206; H-chains in this entry seem to be mistraced in VH region
    1. region b:1-119 [19993]
    2. region d:1-119 [19995]
    3. region f:1-119 [19997]
    4. region h:1-119 [19999]
    5. region j:1-119 [20001]
    6. region l:1-119 [20003]
    7. region n:1-119 [20005]
    8. region p:1-119 [20007]

Generated from scop database 1.73 with scopm 1.101 on Wed Nov 21 11:18:32 2007 Copyright © 1994-2007 The scop authors / scop@mrc-lmb.cam.ac.uk