Structural Classification of Proteins
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Family: V set domains (antibody variable domain-like)

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: Immunoglobulin-like beta-sandwich [48725]
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. Superfamily: Immunoglobulin [48726]
  5. Family: V set domains (antibody variable domain-like) [48727]

Protein Domains:

  1. Immunoglobulin light chain kappa variable domain, VL-kappa [88519]
    VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species
    1. Human (Homo sapiens), cluster 1 [TaxId: 9606] [88520] (18) picpic
    2. Human (Homo sapiens), cluster 2 [TaxId: 9606] [88521] (10) picpic
    3. Human (Homo sapiens), cluster 3.1 [TaxId: 9606] [88522] (8) picpic
    4. Human (Homo sapiens), cluster 3.2 [TaxId: 9606] [88523] (44) picpic
    5. Mouse (Mus musculus), cluster 1.1 [TaxId: 10090] [88524] (127) picpic
    6. Mouse (Mus musculus), cluster 1.2 [TaxId: 10090] [88525] (35) picpic
    7. Mouse (Mus musculus), cluster 2 [TaxId: 10090] [88526] (32) picpic
    8. Mouse (Mus musculus), cluster 3.1 [TaxId: 10090] [88527] (14) picpic
    9. Mouse (Mus musculus), cluster 3.2 [TaxId: 10090] [88528] (59) picpic
    10. Mouse (Mus musculus), cluster 3.3 [TaxId: 10090] [88529] (2) picpic
    11. Mouse (Mus musculus), cluster 3.4 [TaxId: 10090] [88530] (3) picpic
    12. Mouse (Mus musculus), cluster 4 [TaxId: 10090] [88531] (185) picpic
    13. Rat (Rattus norvegicus) [TaxId: 10116] [88532] (9) picpic
    14. Engineered (including hybrid species) [88533] (53) picpic
  2. Immunoglobulin light chain lambda variable domain, VL-lambda [88534]
    VL-lambda domains of human antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the human genome; mouse VL-lambda domains belong to a single germline family
    1. Human (Homo sapiens), cluster 1 [TaxId: 9606] [88535] (4) picpic
    2. Human (Homo sapiens), cluster 2 [TaxId: 9606] [88536] (9) picpic
    3. Human (Homo sapiens), cluster 3.1 [TaxId: 9606] [88537] (1) picpic
    4. Human (Homo sapiens), cluster 3.2 [TaxId: 9606] [88538] (1) picpic
    5. Human (Homo sapiens), cluster 4 [TaxId: 9606] [88539] (23) picpic
    6. Human (Homo sapiens), cluster 5 [TaxId: 9606] [88540] (6) picpic
    7. Mouse (Mus musculus) [TaxId: 10090] [88541] (33) picpic
    8. Rat (Rattus norvegicus) [TaxId: 10116] [101504] (8) picpic
    9. Hamster (Cricetulus griseus) [TaxId: 10029] [88542] (1) picpic
  3. Immunoglobulin heavy chain variable domain, VH [88543]
    VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species
    1. Human (Homo sapiens), cluster 1 [TaxId: 9606] [88544] (42) picpic
    2. Human (Homo sapiens), cluster 2.1 [TaxId: 9606] [88545] (3) picpic
    3. Human (Homo sapiens), cluster 2.2 [TaxId: 9606] [88546] (1) picpic
    4. Human (Homo sapiens), cluster 3 [TaxId: 9606] [88547] (28) picpic
    5. Human (Homo sapiens), cluster 4 [TaxId: 9606] [101505] (2) picpic
    6. Mouse (Mus musculus), cluster 1 [TaxId: 10090] [88548] (43) picpic
    7. Mouse (Mus musculus), cluster 2.1 [TaxId: 10090] [88549] (16) picpic
    8. Mouse (Mus musculus), cluster 2.2 [TaxId: 10090] [88550] (52) picpic
    9. Mouse (Mus musculus), cluster 3.1 [TaxId: 10090] [88551] (34) picpic
    10. Mouse (Mus musculus), cluster 3.2 [TaxId: 10090] [88552] (152) picpic
    11. Mouse (Mus musculus), cluster 3.3 [TaxId: 10090] [88553] (1) picpic
    12. Mouse (Mus musculus), cluster 4 [TaxId: 10090] [88554] (35) picpic
    13. Mouse (Mus musculus), cluster 5 [TaxId: 10090] [88555] (36) picpic
    14. Mouse (Mus musculus), cluster 6 [TaxId: 10090] [88556] (12) picpic
    15. Mouse (Mus musculus), cluster 7.1 [TaxId: 10090] [88557] (37) picpic
    16. Mouse (Mus musculus), cluster 7.2 [TaxId: 10090] [88558] (22) picpic
    17. Mouse (Mus musculus), cluster 7.3 [TaxId: 10090] [88559] (2) picpic
    18. Rat (Rattus norvegicus) [TaxId: 10116] [88560] (15) picpic
    19. Hamster (Cricetulus griseus) [TaxId: 10029] [88561] (1) picpic
    20. Engineered (including hybrid species) [88562] (81) picpic
  4. Camelid IG heavy chain variable domain, VHh [88563]
    1. Camel (Camelus dromedarius) [TaxId: 9838] [88564] (13) picpic
    2. Llama (Lama glama) [TaxId: 9844] [88565] (9) picpic
  5. T-cell antigen receptor [48933]
    sequences may differ within each classified species
    1. Mouse (Mus musculus), alpha-chain [TaxId: 10090] [48934] (17) picpic
    2. Human (Homo sapiens), alpha-chain [TaxId: 9606] [48935] (10) picpic
    3. Mouse (Mus musculus), beta-chain [TaxId: 10090] [48936] (19) picpic
    4. Human (Homo sapiens), beta-chain [TaxId: 9606] [48937] (22) picpic
    5. Human (Homo sapiens), gamma-chain [TaxId: 9606] [63651] (1) picpic
    6. Human (Homo sapiens), delta-chain [TaxId: 9606] [48938] (2) picpic
  6. Immunoreceptor CTLA-4 (CD152), N-terminal fragment [48939]
    1. Human (Homo sapiens) [TaxId: 9606] [48940] (3) picpic
    2. Mouse (Mus musculus) [TaxId: 10090] [48941] (1) picpic
  7. Myelin membrane adhesion molecule P0 [48728]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [48729] (1) picpic
  8. Myelin oligodendrocyte glycoprotein (MOG) [89174]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [89175] (3) picpic
  9. Coxsackie virus and adenovirus receptor (Car), domain 1 [48730]
    1. Human (Homo sapiens) [TaxId: 9606] [48731] (19) picpic
  10. N-terminal domain of sialoadhesin [48732]
    1. Mouse (Mus musculus) [TaxId: 10090] [48733] (8) picpic
  11. N-terminal domain of sialic acid binding Ig-like lectin 7 (SIGLEC-7, p75/AIRM1) [89176]
    1. Human (Homo sapiens) [TaxId: 9606] [89177] (6) picpic
  12. NK cell activating receptor NKP44 [89178]
    a triggering partner in natural cytotoxicity
    1. Human (Homo sapiens) [TaxId: 9606] [89179] (1) picpic
  13. TREM-1 (triggering receptor expressed on myeloid cells 1) [101506]
    1. Human (Homo sapiens) [TaxId: 9606] [101507] (2) picpic
    2. Mouse (Mus musculus) [TaxId: 10090] [117037] (1) picpic
  14. CD8 [48734]
    1. Human (Homo sapiens) [TaxId: 9606] [48735] (2) picpic
    2. Mouse (Mus musculus) [TaxId: 10090] [48736] (6) picpic
  15. CD4 V-set domains [48737]
    1. Human (Homo sapiens) [TaxId: 9606] [48738] (25) picpic
    2. Rat (Rattus rattus) [TaxId: 10117] [48739] (1) picpic
  16. CD2, first domain [48740]
    1. Human (Homo sapiens) [TaxId: 9606] [48741] (4) picpic
    2. Rat (Rattus norvegicus) [TaxId: 10116] [48742] (5) picpic
  17. CD2-binding domain of CD58, N-terminal domain [48743]
    1. Human (Homo sapiens) [TaxId: 9606] [48744] (3) picpic
  18. CD80, N-terminal domain [48745]
    a soluble form of b7-1
    1. Human (Homo sapiens) [TaxId: 9606] [48746] (2) picpic
  19. CD86 (b7-2), N-terminal domain [63635]
    1. Human (Homo sapiens) [TaxId: 9606] [63636] (2) picpic
  20. Junction adhesion molecule, JAM, N-terminal domain [48747]
    1. Mouse (Mus musculus) [TaxId: 10090] [48748] (1) picpic
    2. Human (Homo sapiens) [TaxId: 9606] [89180] (1) picpic
  21. Biliary glycoprotein C (CD66a, CEACAM1A[1,4]), N-terminal domain [81942]
    1. Mouse (Mus musculus) [TaxId: 10090] [81943] (1) picpic
  22. Tyrosine-protein kinase receptor tyro3, N-terminal domain [101508]
    1. Human (Homo sapiens) [TaxId: 9606] [101509] (1) picpic
  23. Programmed cell death protein 1, PD1, extracellular domain [101510]
    1. Mouse (Mus musculus) [TaxId: 10090] [101511] (1) picpic
  24. HSV glycoprotein D [63637]
    1. Herpes simplex virus type 1 [TaxId: 10298] [63638] (2) picpic
      elaborated with insertions and N- and C-terminal extensions
  25. Novel antigen receptor (against lysozyme) [110042]
    1. Nurse shark (Ginglymostoma cirratum) [TaxId: 7801] [110043] (2) picpic
  26. Novel antigen receptor 12Y-1 [110044]
    1. Spotted wobbegong (Orectolobus maculatus) [TaxId: 168098] [110045] (1) picpic
  27. Novel antigen receptor 12Y-2 [110046]
    1. Spotted wobbegong (Orectolobus maculatus) [TaxId: 168098] [110047] (1) picpic
  28. Polymeric-immunoglobulin receptor, PIGR [117038]
    1. Human (Homo sapiens) [TaxId: 9606] [117039] (1) picpic
  29. Alphaherpesvirus glycoprotein E [141008]
    elaborated with insertions and C-terminal extensions
    1. Human herpesvirus 1 [TaxId: 10298] [141009] (4) picpic
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MRC site Generated from scop database 1.73 with scopm 1.101 on Wed Nov 21 11:18:32 2007
Copyright © 1994-2007 The scop authors / scop@mrc-lmb.cam.ac.uk