Structural Classification of Proteins
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Fold: PDZ domain-like

contains barrel, partly opened; n*=4, S*=8; meander; capped by alpha-helix

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: PDZ domain-like [50155]
    contains barrel, partly opened; n*=4, S*=8; meander; capped by alpha-helix

Superfamilies:

  1. PDZ domain-like [50156] (4)
    peptide-binding domain
    1. PDZ domain [50157] (55)
      Pfam 00595
      1. Discs large protein homolog [50158]
        1. Human (Homo sapiens) [TaxId: 9606] [50159] (4) picpic
      2. Cask/Lin-2 [50160]
        1. Human (Homo sapiens) [TaxId: 9606] [50161] (1) picpic
      3. Synapse-associated protein 102 [101713]
        1. Human (Homo sapiens) [TaxId: 9606] [101714] (2) picpic
      4. Synaptic protein PSD-95 [50162]
        Synonym: synapse associated protein 90, sap90
        duplication: contains three PDZ domains
        1. Rat (Rattus norvegicus) [TaxId: 10116] [50163] (9) picpic
        2. Human (Homo sapiens) [TaxId: 9606] [74932] (1) picpic
      5. Syntrophin [50164]
        1. Mouse (Mus musculus) [TaxId: 10090] [50165] (3) picpic
      6. Syntenin 1 [89311]
        1. Human (Homo sapiens) [TaxId: 9606] [89312] (26) picpic
      7. Segment polarity protein dishevelled homolog Dvl-2 [89313]
        1. African clawed frog (Xenopus laevis) [TaxId: 8355] [89314] (5) picpic
        2. Mouse (Mus musculus) [TaxId: 10090] [101715] (1) picpic
      8. Neuronal nitric oxide synthase, NNOS [50166]
        1. Rat (Rattus norvegicus) [TaxId: 10116] [50167] (3) picpic
      9. Phosphatase hPTP1e [50168]
        1. Human (Homo sapiens) [TaxId: 9606] [50169] (3) picpic
        2. Mouse (Mus musculus) [TaxId: 10090] [74930] (3) picpic
      10. Na+/H+ exchanger regulatory factor, NHERF [63754]
        1. Human (Homo sapiens) [TaxId: 9606] [63755] (4) picpic
      11. Inad [63756]
        1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [63757] (1) picpic
      12. Glutamate receptor interacting protein [82083]
        1. Rat (Rattus norvegicus) [TaxId: 10116] [82084] (3) picpic
        2. Mouse (Mus musculus) [TaxId: 10090] [110177] (1) picpic
      13. Erbin [82085]
        1. Human (Homo sapiens) [TaxId: 9606] [82086] (5) picpic
      14. GTPase-binding domain of the cell polarity protein par6 (Par-6B) [89315]
        1. Mouse (Mus musculus) [TaxId: 10090] [89316] (1) picpic
        2. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [101716] (3) picpic
      15. Glutamate receptor-interacting protein 1, GRIP1 [101717]
        1. Rat (Rattus norvegicus) [TaxId: 10116] [101718] (2) picpic
      16. Membrane associated guanylate kinase inverted-2 (MAGI-2, KIAA0705) [101719]
        1. Human (Homo sapiens) [TaxId: 9606] [101720] (5) picpic
      17. KIAA1526 protein [101721]
        1. Human (Homo sapiens) [TaxId: 9606] [101722] (3) picpic
      18. Hypothetical protein KIAA1095 [101723]
        1. Human (Homo sapiens) [TaxId: 9606] [101724] (2) picpic
      19. Discs large 5 protein KIAA0583 [101725]
        1. Human (Homo sapiens) [TaxId: 9606] [101726] (1) picpic
      20. Hypothetical protein KIAA0559 [101727]
        1. Human (Homo sapiens) [TaxId: 9606] [101728] (1) picpic
      21. Hypothetical protein KIAA1849 [101729]
        1. Human (Homo sapiens) [TaxId: 9606] [101730] (1) picpic
      22. Scribble (KIAA0147) [101731]
        1. Human (Homo sapiens) [TaxId: 9606] [101732] (3) picpic
      23. Shank1, PDZ domain [101733]
        SH3 and multiple ankyrin repeat domains protein 1
        1. Rat (Rattus norvegicus) [TaxId: 10116] [101734] (2) picpic
      24. Zasp (Cypher, Oracle 1) [101735]
        1. Human (Homo sapiens) [TaxId: 9606] [101736] (1) picpic
        2. Mouse (Mus musculus) [TaxId: 10090] [117173] (1) picpic
      25. Alpha-actinin-2 associated LIM protein [110178]
        1. Mouse (Mus musculus) [TaxId: 10090] [110179] (1) picpic
      26. Glutamate receptor interacting protein 2, GRIP2 (KIAA1719) [110180]
        1. Human (Homo sapiens) [TaxId: 9606] [110181] (2) picpic
      27. Harmonin [110182]
        1. Mouse (Mus musculus) [TaxId: 10090] [110183] (1) picpic
        2. Human (Homo sapiens) [TaxId: 9606] [141263] (1) picpic
      28. Rhophilin-2 [110184]
        1. Mouse (Mus musculus) [TaxId: 10090] [110185] (1) picpic
      29. PDZ-LIM protein mystique [110186]
        1. Mouse (Mus musculus) [TaxId: 10090] [110187] (1) picpic
      30. Enigma homolog ENH [117174]
        1. Mouse (Mus musculus) [TaxId: 10090] [117175] (1) picpic
      31. DNA Regulating synaptic membrane exocytosis protein 2, RIMS2 [117176]
        1. Human (Homo sapiens) [TaxId: 9606] [117177] (1) picpic
      32. Partitioning-defective 3-like protein, PAR3-L (RIKEN cDNA 2810455b10) [117178]
        1. Mouse (Mus musculus) [TaxId: 10090] [117179] (1) picpic
      33. Regulator of G-protein signaling 3, RGS3 [117180]
        1. Mouse (Mus musculus) [TaxId: 10090] [117181] (1) picpic
        2. Human (Homo sapiens) [TaxId: 9606] [141264] (2) picpic
      34. PDZ domain containing protein 11, Pdzk11 [117182]
        1. Mouse (Mus musculus) [TaxId: 10090] [117183] (1) picpic
      35. hypothetical PDZ domain containing protein Uqcrc2 (4930408O21Rik) [117184]
        1. Mouse (Mus musculus) [TaxId: 10090] [117185] (1) picpic
      36. Tight junction protein ZO-2, Tjp2 [141265]
        1. Mouse (Mus musculus) [TaxId: 10090] [141266] (1) picpic
      37. Multiple PDZ domain protein [141267]
        1. Human (Homo sapiens) [TaxId: 9606] [141268] (4) picpic
      38. Afadin [141269]
        1. Human (Homo sapiens) [TaxId: 9606] [141270] (3) picpic
      39. Syntaxin binding protein 4 [141271]
        1. Mouse (Mus musculus) [TaxId: 10090] [141272] (1) picpic
      40. Channel associated protein of synapse-110 [141273]
        Discs large homolog 2, PSD-93
        1. Human (Homo sapiens) [TaxId: 9606] [141274] (1) picpic
      41. Maguk p55 subfamily member 5 [141275]
        1. Mouse (Mus musculus) [TaxId: 10090] [141276] (1) picpic
          Structure of the second L27 domain is known (scop_sp 101293)
      42. Neurabin-i [141277]
        1. Human (Homo sapiens) [TaxId: 9606] [141278] (1) picpic
      43. Regulating synaptic membrane exocytosis protein 1, RIMS1 [141279]
        1. Rat (Rattus norvegicus) [TaxId: 10116] [141280] (1) picpic
        2. Human (Homo sapiens) [TaxId: 9606] [141281] (1) picpic
      44. Amyloid beta A4 precursor protein-binding family A member 1 (APBA1, X11) [141282]
        1. Human (Homo sapiens) [TaxId: 9606] [141283] (7) picpic
          structure of the PTB domain is also known (scop_sp 50757)
      45. Presynaptic protein sap97 [141284]
        PSD-95 homologue
        1. Rat (Rattus norvegicus) [TaxId: 10116] [141285] (1) picpic
      46. Tyrosine-protein phosphatase non-receptor type 4, PTPN4 [141286]
        1. Human (Homo sapiens) [TaxId: 9606] [141287] (1) picpic
    2. Tail specific protease PDZ domain [68933] (2)
      1. Photosystem II D1 C-terminal processing protease [68934]
        1. Algae (Scenedesmus obliquus) [TaxId: 3088] [50171] (4) picpic
      2. Tricorn protease [69253]
        1. Archaeon Thermoplasma acidophilum [TaxId: 2303] [69254] (4) picpic
    3. HtrA-like serine proteases [74933] (4)
      1. Protease Do (DegP, HtrA), C-terminal domains [74934]
        duplication: tandem repeat of two PDZ domains
        1. Escherichia coli [TaxId: 562] [74935] (1) picpic
      2. Mitochondrial serine protease HtrA2 [74936]
        1. Human (Homo sapiens) [TaxId: 9606] [74937] (1) picpic
      3. Stress sensor protease DegS, C-terminal domain [110188]
        1. Escherichia coli [TaxId: 562] [110189] (4) picpic
      4. Protease PepD [141288]
        1. Mycobacterium tuberculosis [TaxId: 1773] [141289] (3) picpic
          Rv0983
    4. Interleukin 16 [50172] (1)
      1. Interleukin 16 [50173]
        1. Human (Homo sapiens) [TaxId: 9606] [50174] (2) picpic
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MRC site Generated from scop database 1.73 with scopm 1.101 on Wed Nov 21 11:18:32 2007
Copyright © 1994-2007 The scop authors / scop@mrc-lmb.cam.ac.uk