Class: All beta proteins

Lineage:

1. Root: scop
2. Class: All beta proteins [48724]

Folds:

1. Immunoglobulin-like beta-sandwich [48725] (27)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands
2. Common fold of diphtheria toxin/transcription factors/cytochrome f [49379] (10)
   sandwich; 9 strands in 2 sheet; greek-key; subclass of immunoglobin-like fold
3. Prealbumin-like [49451] (7)
   sandwich; 7 strands in 2 sheets, greek-key
   variations: some members have additional 1-2 strands to common fold
4. HSP40/DnaJ peptide-binding domain [49492] (1)
   sandwich; 6 strands in 2 sheets
5. Penicillin-binding protein associated domain [69188] (1)
   sandwich; 6 strands in 2 sheets
6. alpha-Amylase inhibitor tendamistat [49497] (1)
   sandwich; 6 strands in 2 sheets
7. C-terminal domain of mollusc hemocyanin [81278] (1)
   six-stranded beta-sandwich, jelly-roll/greek-key topology
8. HPA-like [141085] (1)
   sandwich, 6 strands in 2 sheets; jelly-roll (truncated); also includes the pending PCSK9 V domain-like superfamily (the C-terminal domains of 2p4e and 2pmw)
9. L21p-like [141090] (1)
   core: sandwich, 6 strands in 2 sheets
10. Cupredoxin-like [49502] (2)
    sandwich; 7 strands in 2 sheets, greek-key
    variations: some members have additional 1-2 strands
11. Ctag/Cox11 [110110] (1)
    sandwich; 7 strands in 2 sheets, greek-key; permutation of the immunoglobulin-like fold
12. Atu1913-like [141098] (1)
    sandwich; 7 strands in two sheets, greek-key/jelly-roll; forms segment swapped dimers, swapping is probably facilitated by the helix insertion after strand 3
13. C2 domain-like [49561] (4)
    sandwich; 8 strands in 2 sheets; greek-key
14. TRAF domain-like [49598] (1)
    sandwich; 8 strands in 2 sheets; greek-key
15. Neurophysin II [49605] (1)
    sandwich; 8 strands in 2 sheets; meander
16. N-utilization substance G protein NusG, insert domain [82003] (1)
    sandwich; 8 strands in 2 sheets; meander
17. Nucleoplasmin-like/VP (viral coat and capsid proteins) [88632] (7)
    sandwich; 8 strands in 2 sheets; jelly-roll; some members can have additional 1-2 strands
    characteristic interaction between the domains of this fold allows the formation of five-fold and pseudo six-fold assemblies
18. gamma-Crystallin-like [49694] (1)
    sandwich; 8 strands in 2 sheets; greek-key
    duplication: has internal pseudo twofold symmetry
19. Lipase/lipooxygenase domain (PLAT/LH2 domain) [49722] (1)
    sandwich; 8 strands in 2 sheets; complex topology
    duplication: has weak internal pseudo twofold symmetry
20. Calpain large subunit, middle domain (domain III) [49757] (1)
    sandwich; 8 strands in 2 sheets; jelly-roll
21. Supernatant protein factor (SPF), C-terminal domain [101575] (1)
    sandwich; 8 strands in 2 sheets; jelly-roll; similarity to the Nucleoplasmin-like/VP fold
22. Hypothetical protein TM1070 [89231] (1)
    sandwich; 8 strands in 2 sheets; jelly-roll
23. Olfactory marker protein [63696] (1)
    sandwich; 8 strands in 2 sheets; jelly-roll
24. HSP20-like chaperones [49763] (1)
    sandwich; 8 strands in 2 sheets; greek-key
25. Heat shock protein 70kD (HSP70), peptide-binding domain [100919] (1)
    beta-sandwich: 8 strands in 2 sheets
26. Ecotin, trypsin inhibitor [49771] (1)
    sandwich; 8 strands in 2 sheets; complex topology with the crossing loops
27. PEBP-like [49776] (1)
    sandwich; 8 strands in 2 sheets; greek-key: partial topological similarity to immunoglobulin-like folds
28. Ganglioside M2 (gm2) activator [63706] (1)
    sandwich; 8 strands in 2 sheets; greek-key: partial topological similarity to immunoglobulin-like folds
29. Nicotinic receptor ligand binding domain-like [63711] (1)
    sandwich; 8 strands in 2 sheets; greek-key: partial topological similarity to immunoglobulin-like folds
30. Beta-galactosidase LacA, domain 3 [117099] (1)
    sandwich; 8 strands in 2 sheets
31. Galactose-binding domain-like [49784] (1)
    sandwich; 9 strands in 2 sheets; jelly-roll
32. Viral protein domain [49817] (1)
    sandwich; 9 strands in 2 sheets; jelly-roll; form trimers
33. Calcium-mediated lectin [82025] (1)
    sandwich; 9 strands in 2 sheets; greek-key
34. Dextranase, N-terminal domain [101595] (1)
    sandwich; 9 strands in 2 sheets; greek-key
35. Unnamed hypothetical protein [101600] (1)
    sandwich; 9 strands in 2 sheets; greek-key/jelly-roll
36. Superantigen (mitogen) Ypm [101605] (1)
    sandwich; 9 strands in 2 sheets; jelly-roll
37. ENV polyprotein, receptor-binding domain [49829] (1)
    sandwich; 9 strands in 2 sheets; greek-key; contains a few helices in loop regions
38. BTV NS2-like ssRNA-binding domain [110131] (1)
    sandwich; 9 strands in 2 sheets; unusual topology with 2 crossover loops
39. Virus attachment protein globular domain [49834] (1)
    sandwich, 10 strands in 2 sheets; greek-key
40. TNF-like [49841] (1)
    sandwich, 10 strands in 2 sheets; jelly-roll
41. CUB-like [49853] (3)
    sandwich, 10 strands in 2 sheets; jelly-roll
42. Hyaluronate lyase-like, C-terminal domain [49862] (1)
    sandwich, 10 strands in 2 sheets; "folded meander"
43. Cytolysin/lectin [63723] (1)
    sandwich, 10 strands in 2 sheets;
44. Putative glucosidase YicI, C-terminal domain [117124] (1)
    sandwich; 10 strands in two sheets
45. CsrA-like [117129] (1)
    sandwich; 10 strands in 2 sheets; intertwined dimer (segment-swapped, 5-stranded greek-key sandwich?)
46. Osmotin, thaumatin-like protein [49869] (1)
    sandwich; 11 strands in 2 sheets
47. SMAD/FHA domain [49878] (1)
    sandwich; 11 strands in 2 sheets; greek-key
48. Soluble secreted chemokine inhibitor, VCCI [49888] (1)
    sandwich; 11 strands in 2 sheets; greek-key
49. Baculovirus p35 protein [49893] (1)
    sandwich; 14 strands in 2 sheets; greek-key
50. Concanavalin A-like lectins/glucanases [49898] (1)
    sandwich; 12-14 strands in 2 sheets; complex topology
51. Supersandwich [49993] (3)
    sandwich; 18 strands in 2 sheets
52. Leukotriene A4 hydrolase N-terminal domain [63736] (1)
    duplication: two beta-sandwiches of similar topologies are fused together in a single three beta-sheet domain
53. EV matrix protein [50011] (1)
    consists of two beta-sandwich domains of similar topologies
54. Viral chemokine binding protein m3 [82045] (1)
    consists of two different beta-sandwich domains of partial topological similarity to immunoglobulin-like folds
55. gp9 [50016] (1)
    consists of two different beta-sandwich domains unrelated to other beta-sandwich folds
56. Flagellar hook protein flgE [117142] (1)
    consists of two different domains; d1: [complex fold made of bifurcated beta-sheets]; d2 (inserted into d1): [beta-sandwich; 8 strands in 2 sheets]
57. ISP domain [50021] (1)
    consists of two all-beta subdomains: conserved small domain has a rubredoxin-like fold; larger domain consists of 6 beta-stands packed in either sandwich of two 3-stranded sheets or closed barrel (n=6; S=8)
58. Obg-fold [82050] (1)
    this fold is formed by three glycine-rich regions inserted into a small 8-stranded beta-sandwich
    these regions form six left-handed collagen-like helices packed and H-bonded together
59. SH3-like barrel [50036] (18)
    barrel, partly opened; n*=4, S*=8; meander
    the last strand is interrupted by a turn of 3-10 helix
60. GroES-like [50128] (2)
    contains barrel, partly opened; n*=4, S*=8; meander
61. PDZ domain-like [50155] (1)
    contains barrel, partly opened; n*=4, S*=8; meander; capped by alpha-helix
62. N-terminal domains of the minor coat protein g3p [50175] (1)
    core: barrel, in some members open; n*=4, S*=8; meander
63. Sm-like fold [50181] (3)
    core: barrel, open; n*=4, S*=8; meander; SH3-like topology
64. Stringent starvation protein B, SspB [101737] (1)
    core: barrel, open; n*=4, S*=8; meander; SH3-like topology; some similarity to the Sm-like fold
65. Rof/RNase P subunit-like [101743] (1)
    core: barrel, open; n*=4, S*=8; meander; SH3-like topology; some similarity to the Sm-like fold
66. Hydrophobin II, HfbII [101750] (1)
    core: barrel, closed; n=4, S=8; complex topology; helix-containing crossover connection
67. Ribosomal protein L14 [50192] (1)
    barrel, closed; n=5, S=8, meander
68. OB-fold [50198] (12)
    barrel, closed or partly opened n=5, S=10 or S=8; greek-key
69. PRC-barrel domain [50345] (1)
    core: barrel, partly opened; n*=5, S*=8; meander
70. beta-Trefoil [50352] (8)
    barrel, closed; n=6, S=12; and a hairpin triplet; meander
    duplication: has internal pseudo threefold symmetry
71. Reductase/isomerase/elongation factor common domain [50412] (4)
    barrel, closed; n=6, S=10; greek-key
72. Elongation factor/aminomethyltransferase common domain [50464] (2)
    barrel, closed; n=6, S=10; greek-key
73. Split barrel-like [50474] (2)
    barrel; n=6, S=10; greek-key
74. Phage tail proteins [69278] (1)
    core: barrel; n=6, S=10; greek-key; topologically similar to the FMN-binding split barrel
75. Surface presentation of antigens (SPOA) [101800] (1)
    segment-swapped dimer forming two identical conjoint barrels (n=6, S=10) topologically similar to the FMN-binding split barrel
76. FMT C-terminal domain-like [50485] (1)
    barrel, open; n*=6, S*=10; greek-key
77. Trypsin-like serine proteases [50493] (1)
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
78. Replicase NSP9 [101815] (1)
    barrel; n=6, S=8, greek-key; similar to one trypsin-like protease barrel
79. mu transposase, C-terminal domain [50609] (1)
    barrel; n=6, S=8, greek-key
80. Domain of alpha and beta subunits of F1 ATP synthase-like [50614] (3)
    barrel, closed; n=6, S=8; greek-key
81. Small protein B (SmpB) [74981] (1)
    barrel, closed; n=6, S=8, greek-key, partial similarity to the OB-fold
82. Acid proteases [50629] (1)
    barrel, closed; n=6, S=10, complex topology
83. ValRS/IleRS/LeuRS editing domain [50676] (1)
    core: barrel, closed; n=6, S=8; topology is similar to that of the acid proteases barrel
84. Urease metallochaperone UreE, N-terminal domain [69286] (1)
    barrel, closed; n=6, S=8; a crossover loop topology
85. Double psi beta-barrel [50684] (2)
    barrel, closed; n=6, S=10; complex topology with crossover (psi) loops
86. Ribosomal protein L25-like [50714] (1)
    barrel, closed; n=6, S=10; complex topology
87. Core binding factor beta, CBF [50722] (1)
    barrel, closed; n=6, S=10; meander; capped at both ends by alpha-helices
88. PH domain-like barrel [50728] (2)
    barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix
89. Transcription factor IIA (TFIIA), beta-barrel domain [50783] (1)
    barrel, closed; n=6, S=12; mixed beta-sheet
90. Hcp1-like [141451] (1)
    barrel, closed; n=6, S=12; contains extra, non-barrel strand 7 at the C-terminus
91. Herpes virus serine proteinase, assemblin [50788] (1)
    core: barrel, closed; n=7, S=8; complex topology
92. PK beta-barrel domain-like [50799] (1)
    barrel, closed; n=7, S=10; complex topology
93. XRCC4, N-terminal domain [50808] (1)
    barrel, closed; n=7, S=10; order: 1234765; strands 1 and 5 are parallel to each other
94. HesB-like domain [89359] (1)
    barrel, closed; n=7, S=10; complex topology
95. Bacterial fluorinating enzyme, C-terminal domain [101851] (1)
    barrel, closed; n=7, S=10; greek-key topology; one overside connection
96. SPOC domain-like [100938] (1)
    barrel, closed; n=7, S=10; complex topology
97. BH3618-like [141456] (1)
    barrel, closed; n=7, S=10; meander
98. FAS1 domain [82152] (1)
    core: barrel, closed; n=7, S=12; meander
99. Lipocalins [50813] (1)
    barrel, closed or opened; n=8, S=12; meander
100. Streptavidin-like [50875] (8)
     barrel, closed; n=8, S=10; meander
101. Allene oxide cyclase-like [141492] (1)
     barrel, closed; n=8, S=10; meander; mirrored (reversed) topology to the Spreptavidin-like and Lipocalin-like folds
102. Cyclophilin-like [50890] (1)
     barrel, closed; n=8, S=10; complex topology
103. Oncogene products [50903] (1)
     barrel, closed; n=8, S=10; one overside connection
104. L,D-transpeptidase catalytic domain-like [141522] (1)
     barrel, closed; n=8, S=10; one overside connection
105. Sortase [63816] (1)
     barrel, closed; n=8, S=10; mixed sheet; two overside connections
106. PTSIIA/GutA-like [141529] (1)
     barrel, closed; n=8, S=12; mixed sheet; two overside connections; duplication: consists of two intertwinned structural repeats
107. Mannose 6-phosphate receptor domain [50910] (1)
     barrel, partly open; n*=8, S*=10; one psi loop
108. triple barrel [50915] (1)
     dimer of two non-identical subunits; forms two similar barrels, n=8, S=10 each, that are fused together with the formation of third barrel, n=6, S=8
109. 4-bladed beta-propeller [50922] (1)
     consists of four 4-stranded beta-sheet motifs; meander
110. 5-bladed beta-propeller [50933] (3)
     consists of five 4-stranded beta-sheet motifs; meander
111. 6-bladed beta-propeller [50938] (11)
     consists of six 4-stranded beta-sheet motifs; meander
112. 7-bladed beta-propeller [50964] (14)
     consists of seven 4-stranded beta-sheet motifs; meander
113. 8-bladed beta-propeller [50997] (3)
     consists of eight 4-stranded beta-sheet motifs; meander
     also found in some members of the WD40-repeat superfamily
114. Glycosyl hydrolase domain [51010] (1)
     folded sheet; greek-key
115. WW domain-like [51044] (3)
     core: 3-stranded meander beta-sheet
116. Head domain of nucleotide exchange factor GrpE [51063] (1)
     small mixed beta-sheet, 4 "generalized" strands
117. Coronavirus RNA-binding domain [110303] (1)
     coiled antiparallel beta-sheet of 5 strands, order 51324; complex topology, crossing loops
118. Ribonuclease domain of colicin E3 [63839] (1)
     twisted meander beta-sheet of 6 strands
119. NAC domain [101940] (1)
     core: twisted 7-stranded beta-sheet (half-barrel)
120. At5g01610-like [141561] (1)
     contains large meander beta-sheet bent into a scoop-like shape
121. Carbonic anhydrase [51068] (1)
     single sheet; 10 strands
122. Prokaryotic lipoproteins and lipoprotein localization factors [89391] (1)
     11 stranded sheet partly folded in a corner-like structure filled with a few short helices
123. Bacteriochlorophyll A protein [51080] (1)
     single sheet; 16 strands; meander
124. open-sided beta-meander [51086] (2)
     single sheet formed by beta-hairpin repeats; exposed on both sides in the middle
125. beta-Prism I [51091] (3)
     consists of 3 4-stranded sheets; strands are parallel to the 3-fold axis
     duplication: has internal pseudo threefold symmetry
126. beta-Prism II [51109] (1)
     consists of 3 4-stranded sheets; strands are perpendicular to the 3-fold axis
     duplication: consists of two domains of this fold
127. Single-stranded right-handed beta-helix [51125] (8)
     superhelix turns are made of parallel beta-strands and (short) turns
128. Single-stranded left-handed beta-helix [51160] (3)
     superhelix turns are made of parallel beta-strands and (short) turns
129. Double-stranded beta-helix [51181] (7)
     one turn of helix is made by two pairs of antiparallel strands linked with short turns
     has appearance of a sandwich of distinct architecture and jelly-roll topology
130. Triple-stranded beta-helix [69348] (1)
     (homo)trimer; each chain donates 3 beta-strands per turn of the helix
131. Triple beta-spiral [51224] (1)
     trimer formed by the interlocking beta-hairpin repeat units
132. Trimeric adhesin [101998] (1)
     trimer; contains two different beta-prism-like domains connected by an linker subdomain of less regular structure
133. beta-hairpin stack [69359] (1)
     Trp-rich beta-hairpin repeat units form helical structures of 3 units per turn
134. Barrel-sandwich hybrid [51229] (4)
     sandwich of half-barrel shaped beta-sheets
135. beta-clip [51268] (7)
     double-stranded ribbon sharply bent in two places; the ribbon ends form incomplete barrel; jelly-roll
136. PheT/TilS domain [56036] (1)
     core: 3 layers; contains beta-sandwich of unusual topology
137. C-terminal autoproteolytic domain of nucleoporin nup98 [82214] (1)
     multisheet protein with a mixture of beta-sandwich and beta-prism features
138. Pseudo beta-prism [141657] (1)
     beta-sandwich with one regular beta-sheet and the other beta-sheet bent in the middle with a set of aligned beta-bulges
139. SARS ORF9b-like [141665] (1)
     complex dimeric fold with three intersubunit beta-sheets packed around a single core
140. Adsorption protein p2 [89427] (1)
     multisheet protein containing partial beta-propeller and beta-sandwich regions
141. Baseplate structural protein gp8 [89432] (1)
     multisheet protein with a mixture of beta-sandwich and beta-barrel features
142. Hedgehog/intein (Hint) domain [51293] (1)
     complex fold made of five beta-hairpin units and a b-ribbon arc
143. LexA/Signal peptidase [51305] (1)
     complex fold made of several coiled beta-sheets; contains an SH3-like barrel
144. Cloacin translocation domain [69368] (1)
     complex fold made of several coiled beta-sheets
145. Mss4-like [51315] (1)
     complex fold made of several coiled beta-sheets
146. Cyanovirin-N [51321] (1)
     complex fold
147. Tp47 lipoprotein, N-terminal domain [82219] (1)
     complex fold; consists of two intertwined subdomains
148. Methuselah ectodomain [63876] (1)
     complex fold
149. Head-binding domain of phage P22 tailspike protein [51326] (1)
     complex fold made of bifurcated and partly folded beta-sheet
150. E2 regulatory, transactivation domain [51331] (1)
     complex fold made of bifurcated and coiled beta-sheets
151. MoeA N-terminal region -like [63881] (1)
     complex fold made of bifurcated and coiled b-sheets
152. MOSC N-terminal domain-like [141672] (1)
     complex fold; comprises a beta-hairpin and a meander 3-stranded sheet packed against beta-barrel: closed, n=5, S=8; contains three short helices
153. MAL13P1.257-like [141677] (1)
     complex fold; duplication: consists of two intertwinned structural repeats related by pseudo dyad
154. Composite domain of metallo-dependent hydrolases [51337] (1)
     pseudobarrel; mixed sheet of 7 strand folded upon itself and "buckled" by two beta-turns
155. Epsilon subunit of F1F0-ATP synthase N-terminal domain [51343] (1)
     pseudobarrel: sandwich of two sheets packed at a positive interstrand angle and interconnected with many short turns
156. N-terminal domain of MutM-like DNA repair proteins [81625] (1)
     pseudobarrel; capped on both ends by alpha-helices
157. Hypothetical protein YojF [89441] (1)
     pseudobarrel; capped at one end by an alpha-helix
158. DNA-binding pseudobarrel domain [101935] (1)
     core: barrel, open; n=7, S*=10; capped with helices at both ends; partial similarity to the AbrB/MazE/MraZ-like fold (scop_cf 89446)
159. Double-split beta-barrel [89446] (2)
     pseudobarrel; capped on both ends by alpha-helices
160. PUA domain-like [88696] (1)
     pseudobarrel; mixed folded sheet of 5 strands; order 13452; strand 1 and 3 are parallel to each other
161. AXH domain [102030] (1)
     pseudobarrel; some similarity to OB-fold
162. FimD N-terminal domain-like [141728] (1)
     pseudo barrel, capped by an alpha-helix; some topological similarity to the PRC-barrel domain (scop_sf 50346) and the N-terminal domain of Glutamine synthetase (scop_sf 54368)
163. HisI-like [141733] (1)
     pseudo barrel, capped by an alpha-helix; contains a beta-triangle structure on one side; some topological similarity to the Ribosomal protein L25-like fold (scop_cf 50714) and the N-terminal domain of Glutamine synthetase (scop_sf 54368)
164. MFPT repeat-like [141738] (1)
     consists of two similar pseudo barrel subdomains with structural similarity to a circularly permuted SAND domain (scop_fa 63764)
165. P-domain of calnexin/calreticulin [63886] (1)
     non-globular proline-rich hairpin

Generated from scop database 1.73 with scopm 1.101 on Wed Nov 21 11:18:32 2007 Copyright © 1994-2007 The scop authors / scop@mrc-lmb.cam.ac.uk