Class: Alpha and beta proteins (a/b)

Mainly parallel beta sheets (beta-alpha-beta units)

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b) [51349]
   Mainly parallel beta sheets (beta-alpha-beta units)

Folds:

1. TIM beta/alpha-barrel [51350] (33)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites
   1. Triosephosphate isomerase (TIM) [51351] (1)
   2. Ribulose-phoshate binding barrel [51366] (6)
   3. Thiamin phosphate synthase [51391] (1)
   4. Pyridoxine 5'-phosphate synthase [63892] (1)
   5. FMN-linked oxidoreductases [51395] (1)
   6. Inosine monophosphate dehydrogenase (IMPDH) [51412] (1)
      The phosphate moiety of substrate binds in the 'common' phosphate-binding site
   7. PLP-binding barrel [51419] (2)
      circular permutation of the canonical fold: begins with an alpha helix and ends with a beta-strand
   8. NAD(P)-linked oxidoreductase [51430] (1)
   9. (Trans)glycosidases [51445] (14)
   10. Metallo-dependent hydrolases [51556] (15)
       the beta-sheet barrel is similarly distorted and capped by a C-terminal helix
       has transition metal ions bound inside the barrel
   11. Aldolase [51569] (8)
       Common fold covers whole protein structure
   12. Enolase C-terminal domain-like [51604] (2)
       binds metal ion (magnesium or manganese) in conserved site inside barrel
       N-terminal alpha+beta domain is common to this superfamily
   13. Phosphoenolpyruvate/pyruvate domain [51621] (6)
   14. Malate synthase G [51645] (1)
   15. RuBisCo, C-terminal domain [51649] (1)
   16. Xylose isomerase-like [51658] (7)
       different families share similar but non-identical metal-binding sites
   17. Bacterial luciferase-like [51679] (4)
       consists of clearly related families of somewhat different folds
   18. Nicotinate/Quinolinate PRTase C-terminal domain-like [51690] (2)
       incomplete beta/alpha barrel with parallel beta-sheet of 7 strands
   19. PLC-like phosphodiesterases [51695] (3)
   20. Cobalamin (vitamin B12)-dependent enzymes [51703] (4)
   21. tRNA-guanine transglycosylase [51713] (1)
   22. Dihydropteroate synthetase-like [51717] (2)
   23. UROD/MetE-like [51726] (2)
   24. FAD-linked oxidoreductase [51730] (2)
       distinct cofactor-binding mode from both FMN- and NAD(P)-linked TIM-barrel oxidoreductases; families are related by a circular permutation
   25. Monomethylamine methyltransferase MtmB [75098] (1)
   26. Homocysteine S-methyltransferase [82282] (1)
   27. (2r)-phospho-3-sulfolactate synthase ComA [102110] (1)
   28. Radical SAM enzymes [102114] (3)
       common Fe-S cluster and SAM binding sites are embedded into complete or incomplete beta/alpha-barrel
   29. GlpP-like [110391] (1)
   30. CutC-like [110395] (1)
   31. ThiG-like [110399] (1)
       shares the common phosphate-binding site with other superfamilies
   32. TM1631-like [117396] (1)
   33. EAL domain-like [141868] (1)
       variant of the beta/alpha-barrel fold with strand 1 being antiparallel to the rest
2. NAD(P)-binding Rossmann-fold domains [51734] (1)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar
   1. NAD(P)-binding Rossmann-fold domains [51735] (12)
3. FAD/NAD(P)-binding domain [51904] (1)
   core: 3 layers, b/b/a; central parallel beta-sheet of 5 strands, order 32145; top antiparallel beta-sheet of 3 strands, meander
   1. FAD/NAD(P)-binding domain [51905] (7)
4. Nucleotide-binding domain [51970] (1)
   3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32145; Rossmann-like
   1. Nucleotide-binding domain [51971] (3)
      this superfamily shares the common nucleotide-binding site with and provides a link between the Rossmann-fold NAD(P)-binding and FAD/NAD(P)-binding domains
5. MurCD N-terminal domain [51983] (1)
   3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32145; incomplete Rossmann-like fold; binds UDP group
   1. MurCD N-terminal domain [51984] (1)
6. 7-stranded beta/alpha barrel [51988] (3)
   variant of beta/alpha barrel; parallel beta-sheet barrel, closed, n=7, S=8; strand order 1234567; some members may have fewer strands
   1. Glycosyl hydrolases family 6, cellulases [51989] (1)
   2. PHP domain-like [89550] (2)
   3. Glycoside hydrolase/deacetylase [88713] (7)
      in the different families beta-barrels are similarly distorted but may vary in the number of strands
7. PFL-like glycyl radical enzymes [51997] (1)
   contains: barrel, closed; n=10, S=10; accommodates a hairpin loop inside the barrel
   1. PFL-like glycyl radical enzymes [51998] (4)
      duplication: the N- and C-terminal halves have similar topologies
8. The "swivelling" beta/beta/alpha domain [52008] (10)
   3 layers: b/b/a; the central sheet is parallel, and the other one is antiparallel; there are some variations in topology
   this domain is thought to be mobile in most multi-domain proteins known to contain it
   1. Phosphohistidine domain [52009] (2)
      contains barrel, closed, n=7, S=10
   2. RraA-like [89562] (1)
      structural similarity and possible distant homology to the phosphohistidine domain of pyruvate phosphate dikinase
   3. Putative cyclase [102198] (1)
      contains mixed beta-sheet barrel, closed n=7, S=10
   4. LeuD/IlvD-like [52016] (3)
      contains mixed beta-sheet barrel, closed n=7, S=10
   5. Carbamoyl phosphate synthetase, small subunit N-terminal domain [52021] (1)
   6. Swiveling domain of dehydratase reactivase alpha subunit [82317] (1)
   7. PA domain [52025] (1)
   8. GroEL apical domain-like [52029] (2)
   9. FumA C-terminal domain-like [117457] (1)
   10. LD-carboxypeptidase A C-terminal domain-like [141986] (1)
9. Barstar-like [52037] (2)
   2 layers, a/b; parallel beta-sheet of 3 strands, order 123
   1. Barstar-related [52038] (1)
   2. Ribosomal protein L32e [52042] (1)
10. MurF and HprK N-domain-like [63417] (2)
    core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1234; structural similarity of the MurF and HprK extends beyond the core.
    1. MurE/MurF N-terminal domain [63418] (1)
       binds UDP group
    2. HPr kinase/phoshatase HprK N-terminal domain [75138] (1)
       probable phosphatase
11. Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [52046] (3)
    2 curved layers, a/b; parallel beta-sheet; order 1234...N; there are sequence similarities between different superfamilies
    1. RNI-like [52047] (3)
       regular structure consisting of similar repeats
    2. L domain-like [52058] (8)
       less regular structure consisting of variable repeats
    3. Outer arm dynein light chain 1 [52075] (1)
       (beta-beta-alpha)n superhelix
12. Ribosomal proteins L15p and L18e [52079] (1)
    core: three turns of irregular (beta-beta-alpha)n superhelix
    1. Ribosomal proteins L15p and L18e [52080] (1)
13. SpoIIaa-like [52086] (2)
    core: 4 turns of a (beta-alpha)n superhelix
    1. CRAL/TRIO domain [52087] (1)
    2. Anti-sigma factor antagonist SpoIIaa [52091] (1)
14. ClpP/crotonase [52095] (1)
    core: 4 turns of (beta-beta-alpha)n superhelix
    1. ClpP/crotonase [52096] (4)
15. BRCT domain [52112] (1)
    3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134
    1. BRCT domain [52113] (5)
       Pfam 00533
16. Lumazine synthase [52120] (1)
    3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134
    1. Lumazine synthase [52121] (1)
17. Uracil-DNA glycosylase-like [52140] (1)
    3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134
    1. Uracil-DNA glycosylase-like [52141] (3)
18. Creatininase [102214] (1)
    3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134
    1. Creatininase [102215] (1)
19. DNA polymerase III psi subunit [102219] (1)
    3 layers, a/b/a; parallel beta-sheet of 4 strands, order 2134
    1. DNA polymerase III psi subunit [102220] (1)
20. Initiation factor IF2/eIF5b, domain 3 [52155] (1)
    3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134
    1. Initiation factor IF2/eIF5b, domain 3 [52156] (1)
21. Aminoacid dehydrogenase-like, N-terminal domain [53222] (1)
    core: 3 layers: a/b/a; parallel beta-sheet of 4 strands; 2134
    1. Aminoacid dehydrogenase-like, N-terminal domain [53223] (5)
22. Toprim domain [110454] (1)
    3 layers, a/b/a; parallel beta-sheet of 4 strands, order 2134
    1. Toprim domain [110455] (1)
       this domain is also present in several multidomain proteins that are not split in scop yet: scop_sf 56712, scop_sf 56719, scop_sf 56726, scop_sf 56731
23. Ribosomal protein L13 [52160] (1)
    3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 3214
    1. Ribosomal protein L13 [52161] (1)
24. Ribosomal protein L4 [52165] (1)
    3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 1423
    1. Ribosomal protein L4 [52166] (1)
25. Nqo1 FMN-binding domain-like [142018] (1)
    3 layers, a/b/a; parallel beta-sheet of 4 strands, order 3214
    1. Nqo1 FMN-binding domain-like [142019] (1)
26. Flavodoxin-like [52171] (15)
    3 layers, a/b/a; parallel beta-sheet of 5 strand, order 21345
    1. CheY-like [52172] (7)
    2. Toll/Interleukin receptor TIR domain [52200] (1)
    3. Hypothetical protein MTH538 [52206] (1)
    4. Succinyl-CoA synthetase domains [52210] (1)
    5. Flavoproteins [52218] (8)
    6. Cobalamin (vitamin B12)-binding domain [52242] (1)
    7. N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) [52255] (1)
    8. SGNH hydrolase [52266] (7)
    9. Beta-D-glucan exohydrolase, C-terminal domain [52279] (1)
    10. Formate/glycerate dehydrogenase catalytic domain-like [52283] (3)
    11. Type II 3-dehydroquinate dehydratase [52304] (1)
    12. N-(deoxy)ribosyltransferase-like [52309] (3)
        there are similar active site architectures as well as the catalytic mechanisms of functionally characterised members
    13. Ribosomal protein S2 [52313] (1)
        fold elaborated with additional structures
    14. Precorrin-8X methylmutase CbiC/CobH [63965] (1)
        fold elaborated with additional structures
    15. Class I glutamine amidotransferase-like [52317] (8)
        conserved positions of the oxyanion hole and catalytic nucleophile; different constituent families contain different additional structures
27. Methylglyoxal synthase-like [52334] (1)
    3 layers, a/b/a; parallel beta-sheet of 5 strands, order 32145
    1. Methylglyoxal synthase-like [52335] (3)
       contains a common phosphate-binding site
28. Ferredoxin reductase-like, C-terminal NADP-linked domain [52342] (1)
    3 layers, a/b/a; parallel beta-sheet of 5 strands, order 32145
    1. Ferredoxin reductase-like, C-terminal NADP-linked domain [52343] (5)
       binds NADP differently than classical Rossmann-fold
       N-terminal FAD-linked domain contains (6,10) barrel
29. Adenine nucleotide alpha hydrolase-like [52373] (3)
    core: 3 layers, a/b/a ; parallel beta-sheet of 5 strands, order 32145
    1. Nucleotidylyl transferase [52374] (5)
    2. Adenine nucleotide alpha hydrolases-like [52402] (6)
       share similar mode of ligand (Adenosine group) binding
       can be subdivided into two group with closer relationships within each group than between the groups; the first three families form one group whereas the last two families form the other group
    3. UDP-glucose/GDP-mannose dehydrogenase C-terminal domain [52413] (1)
30. Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain [52417] (1)
    3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32145; Rossmann-like
    1. Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain [52418] (1)
31. Cryptochrome/photolyase, N-terminal domain [52424] (1)
    3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32145; Rossmann-like
    1. Cryptochrome/photolyase, N-terminal domain [52425] (1)
32. DsrEFH-like [75168] (1)
    3 layers: a/b/a, core: parallel beta-sheet of 5 strands, order 43215
    1. DsrEFH-like [75169] (2)
33. PIN domain-like [88722] (1)
    3 layers, a/b/a; core: parallel beta-sheet of 5 strands, order 32145
    1. PIN domain-like [88723] (2)
34. Ribose/Galactose isomerase RpiB/AlsB [89622] (1)
    3 layers: a/b/a, core: parallel beta-sheet of 5 strands, order 21354; topological similarity to a part of the arginase/deacetylase fold
    1. Ribose/Galactose isomerase RpiB/AlsB [89623] (1)
35. alpha/beta knot [75216] (1)
    core: 3 layers: a/b/a, parallel beta-sheet of 5 strands, order 21435; contains a deep trefoil knot
    1. alpha/beta knot [75217] (5)
       known or predicted SAM-dependent methytransferases including the SPOUT 'sequence' superfamily
       all known members have dimeric structures
36. PreATP-grasp domain [52439] (1)
    3 layers: a/b/a; parallel or mixed beta-sheet of 4 to 6 strands
    possible rudiment form of Rossmann-fold domain
    1. PreATP-grasp domain [52440] (7)
       precedes the ATP-grasp domain common to all superfamily members, can contain a substrate-binding function
37. DHS-like NAD/FAD-binding domain [52466] (1)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like
    1. DHS-like NAD/FAD-binding domain [52467] (6)
       binds cofactor molecules in the opposite direction than classical Rossmann fold
38. Tubulin nucleotide-binding domain-like [52489] (1)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456
    1. Tubulin nucleotide-binding domain-like [52490] (1)
39. Isochorismatase-like hydrolases [52498] (1)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456
    1. Isochorismatase-like hydrolases [52499] (1)
40. Dipeptide transport protein [63991] (1)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; also contains a C-terminal alpha+beta subdomain
    1. Dipeptide transport protein [63992] (1)
41. Homo-oligomeric flavin-containing Cys decarboxylases, HFCD [52506] (1)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456
    1. Homo-oligomeric flavin-containing Cys decarboxylases, HFCD [52507] (1)
42. HAD-like [56783] (1)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456
    1. HAD-like [56784] (23)
       usually contains an insertion (sub)domain after strand 1
43. NagB/RpiA/CoA transferase-like [100949] (1)
    core: 3 layers: a/b/a; parallel or mixed beta-sheet of 6 strands, order 321456
    1. NagB/RpiA/CoA transferase-like [100950] (7)
44. Hypothetical protein MTH777 (MT0777) [75180] (1)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456
    1. Hypothetical protein MTH777 (MT0777) [75181] (1)
45. Thiamin pyrophosphokinase, catalytic domain [63998] (1)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 432156
    1. Thiamin pyrophosphokinase, catalytic domain [63999] (1)
46. Undecaprenyl diphosphate synthase [64004] (1)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 342156
    1. Undecaprenyl diphosphate synthase [64005] (1)
       the sheet topology is similar to those of the N-terminal domain of phosphoglycerate kinase and carbamate kinase
47. F420-dependent methylenetetrahydromethanopterin dehydrogenase (MTD) [102323] (1)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213456
    1. F420-dependent methylenetetrahydromethanopterin dehydrogenase (MTD) [102324] (1)
       the sheet topology is similar to those of the Periplasmic binding protein-like I domains
48. Thiamin diphosphate-binding fold (THDP-binding) [52517] (1)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
    1. Thiamin diphosphate-binding fold (THDP-binding) [52518] (8)
       there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
       two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
49. P-loop containing nucleoside triphosphate hydrolases [52539] (1)
    3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes
    1. P-loop containing nucleoside triphosphate hydrolases [52540] (24)
       division into families based on beta-sheet topologies
50. PTS IIb component [52727] (1)
    3 layers: a/b/a, parallel beta-sheet of 6 strands, order 324156
    1. PTS IIb component [52728] (1)
51. DNA polymerase III chi subunit [102399] (1)
    3 layers, a/b/a; parallel beta-sheet of 7 strands, order 7165243
    1. DNA polymerase III chi subunit [102400] (1)
       structural similarity and possible evolutionary relationship to the AAA domain; lacks the P-loop motif
52. Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) [52732] (1)
    3 layers: a/b/a, parallel beta-sheet of 7 strands, order 3214567
    1. Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) [52733] (1)
53. CofD-like [142337] (1)
    3 layers: a/b/a, parallel beta-sheet of 7 strands, order 3214567; topological similarity to the CobT-like fold (scop_cf 52732)
    1. CofD-like [142338] (1)
54. MoCo carrier protein-like [102404] (1)
    3 layers: a/b/a, parallel beta-sheet of 7 strands, order 4321567
    1. MoCo carrier protein-like [102405] (1)
55. Methylesterase CheB, C-terminal domain [52737] (1)
    3 layers: a/b/a, parallel beta-sheet of 7 strands, order 3421567
    1. Methylesterase CheB, C-terminal domain [52738] (1)
56. Subtilisin-like [52742] (1)
    3 layers: a/b/a, parallel beta-sheet of 7 strands, order 2314567; left-handed crossover connection between strands 2 & 3
    1. Subtilisin-like [52743] (2)
57. Indigoidine synthase A-like [110580] (1)
    core: 3 layers, a/b/a; parallel beta-sheet of 7 strands, order 2134756
    1. Indigoidine synthase A-like [110581] (1)
58. Arginase/deacetylase [52767] (1)
    3 layers: a/b/a, parallel beta-sheet of 8 strands, order 21387456
    1. Arginase/deacetylase [52768] (2)
59. Alpha-2,3/8-sialyltransferase CstII [102413] (1)
    3 layers: a/b/a; parallel beta-sheet of 8 strands, order 54321678
    1. Alpha-2,3/8-sialyltransferase CstII [102414] (1)
60. Cell-division inhibitor MinC, N-terminal domain [64042] (1)
    beta(2)-(alpha-beta)2-beta; 2 layers, a/b; mixed beta-sheet of 5 strands, order 12345; strands 1 & 5 are antiparallel to the rest
    1. Cell-division inhibitor MinC, N-terminal domain [64043] (1)
61. DTD-like [69499] (1)
    beta(2)-(alpha-beta)2-beta(3); 3 layers, a/b/b; some topological similarity to the N-terminal domain of MinC
    1. DTD-like [69500] (1)
       active form is a dimer
62. CoA-dependent acyltransferases [52776] (1)
    core: 2 layers, a/b; mixed beta-sheet of 6 strands, order 324561; strands 3 & 6 are antiparallel to the rest
    1. CoA-dependent acyltransferases [52777] (3)
63. Phosphotyrosine protein phosphatases I-like [52787] (2)
    3 layers: a/b/a; parallel beta-sheet of 4 strands, order 2134
    1. Phosphotyrosine protein phosphatases I [52788] (1)
       share the common active site structure with the family II
    2. PTS system, Lactose/Cellobiose specific IIB subunit [52794] (1)
64. (Phosphotyrosine protein) phosphatases II [52798] (1)
    core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423
    1. (Phosphotyrosine protein) phosphatases II [52799] (5)
       share with the family I the common active site structure with a circularly permuted topology
65. Rhodanese/Cell cycle control phosphatase [52820] (1)
    3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32451
    1. Rhodanese/Cell cycle control phosphatase [52821] (4)
       Pfam 00581
       the active site structure is similar to those of the families I and II protein phosphatases; the topology can be related by a different circular permutation to the family I topology
66. Thioredoxin fold [52832] (2)
    core: 3 layers, a/b/a; mixed beta-sheet of 4 strands, order 4312; strand 3 is antiparallel to the rest
    1. Thioredoxin-like [52833] (22)
    2. RNA 3'-terminal phosphate cyclase, RPTC, insert domain [52913] (1)
67. Peptidyl-tRNA hydrolase II [102461] (1)
    3 layers: a/b/a; mixed beta-sheet of 4 strands, order 2143, strand 4 is antiparallel to the rest
    1. Peptidyl-tRNA hydrolase II [102462] (1)
68. TK C-terminal domain-like [52921] (1)
    3 layers: a/b/a; mixed beta-sheet of 5 strands, order 13245, strand 1 is antiparallel to the rest
    1. TK C-terminal domain-like [52922] (3)
69. Pyruvate kinase C-terminal domain-like [52934] (2)
    3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32145, strand 5 is antiparallel to the rest
    1. PK C-terminal domain-like [52935] (2)
    2. ATP synthase (F1-ATPase), gamma subunit [52943] (1)
       contains an antiparallel coiled coil formed by N- and C-terminal extensions to the common fold
70. Anticodon-binding domain-like [52953] (5)
    3 layers: a/b/a; mixed beta-sheet of five strands, order 21345; strand 4 is antiparallel to the rest
    1. Class II aaRS ABD-related [52954] (2)
    2. TolB, N-terminal domain [52964] (1)
    3. B12-dependent dehydatase associated subunit [52968] (2)
    4. ITPase-like [52972] (3)
       formerly Maf/Ham1; elaborated with additional structures inserted in the common fold
    5. CinA-like [142433] (1)
71. MTH938-like [64075] (1)
    core: 3 layers, b+a/b/a ; the central mixed sheet of 5 strands: order 21534; strand 2 is antiparallel to the rest
    1. MTH938-like [64076] (1)
72. Restriction endonuclease-like [52979] (3)
    core: 3 layers, a/b/a; mixed beta-sheet of 5 strands, order 12345; strands 2 &, in some families, 5 are antiparallel to the rest
    1. Restriction endonuclease-like [52980] (31)
    2. tRNA-intron endonuclease catalytic domain-like [53032] (1)
    3. Eukaryotic RPB5 N-terminal domain [53036] (1)
73. Resolvase-like [53040] (2)
    Core: 3 layers: a/b/a; mixed beta-sheet of 5 strands, order 21345; strand 5 is antiparallel to the rest
    1. Resolvase-like [53041] (1)
    2. beta-carbonic anhydrase, cab [53056] (1)
74. IIA domain of mannose transporter, IIA-Man [53061] (1)
    3 layers: a/b/a; mixed beta-sheet of 5 strands, order 21345; strand 5 is antiparallel to the rest
    1. IIA domain of mannose transporter, IIA-Man [53062] (1)
       active dimer is formed by strand 5 swapping
75. Ribonuclease H-like motif [53066] (7)
    3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32145; strand 2 is antiparallel to the rest
    1. Actin-like ATPase domain [53067] (13)
       duplication contains two domains of this fold
    2. Creatinase/prolidase N-terminal domain [53092] (1)
    3. Ribonuclease H-like [53098] (12)
       consists of one domain of this fold
    4. Translational machinery components [53137] (2)
    5. Nitrogenase accessory factor-like [53146] (2)
    6. DNA repair protein MutS, domain II [53150] (1)
    7. Methylated DNA-protein cysteine methyltransferase domain [53155] (1)
76. Phosphorylase/hydrolase-like [53162] (7)
    core: 3 layers, a/b/a ; mixed sheet of 5 strands: order 21354; strand 4 is antiparallel to the rest; contains crossover loops
    1. HybD-like [53163] (2)
       the HybD fold coincides with the consensus core structure
    2. Purine and uridine phosphorylases [53167] (1)
       complex architecture; contains mixed beta-sheet of 8 strands, order 23415867, strands 3, 6 & 7 are antiparallel to the rest; and barrel, closed; n=5, S=8
    3. Peptidyl-tRNA hydrolase-like [53178] (1)
    4. Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) [53182] (1)
    5. Zn-dependent exopeptidases [53187] (8)
       core: mixed beta-sheet of 8 strands, order 12435867; strands 2, 6 & 7 are antiparallel to the rest
    6. LigB subunit of an aromatic-ring-opening dioxygenase LigAB [53213] (1)
       circular permutation of the common fold, most similar to the PNP fold
    7. AF0625-like [142535] (1)
       contains extra C-terminal alpha/beta domain: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 2134
77. Molybdenum cofactor biosynthesis proteins [53217] (1)
    3 layers: a/b/a; mixed beta-sheet of 5 strands; order: 21354, strand 5 is antiparallel to the rest; permutation of the Phosphorylase/hydrolase-like fold
    1. Molybdenum cofactor biosynthesis proteins [53218] (2)
78. Bacterial fluorinating enzyme, N-terminal domain [102521] (1)
    3 layers: a/b/a; mixed beta-sheet of 6 strands; order: 213546, strand 5 is antiparallel to the rest; topological similarity to the MogA-like family fold
    1. Bacterial fluorinating enzyme, N-terminal domain [102522] (1)
79. Caspase-like [52128] (1)
    3 layers, a/b/a; core: mixed beta-sheet of 6 strands, order 213456, strand 6 is antiparallel to the rest
    1. Caspase-like [52129] (2)
       mature protein may be composed of two chains folded in a single domain
80. Macro domain-like [52948] (1)
    3 layers: a/b/a; mixed beta-sheet of 6 strands, order 165243, strand 3 is antiparallel to the rest
    1. Macro domain-like [52949] (2)
81. MurD-like peptide ligases, peptide-binding domain [53243] (1)
    3 layers: a/b/a; mixed beta-sheet of 6 strands, order 126345; strand 1 is antiparallel to the rest
    1. MurD-like peptide ligases, peptide-binding domain [53244] (2)
82. Phosphoglycerate mutase-like [53253] (1)
    core: 3 layers, a/b/a; mixed beta-sheet of 6 strands, order 324156; strand 5 is antiparallel to the rest
    1. Phosphoglycerate mutase-like [53254] (3)
83. PRTase-like [53270] (1)
    core: 3 layers, a/b/a; mixed beta-sheet of 6 strands, order 321456; strand 3 is antiparallel to the rest
    1. PRTase-like [53271] (2)
84. vWA-like [53299] (1)
    core: 3 layers, a/b/a; mixed beta-sheet of 6 strands, order 321456; strand 3 is antiparallel to the rest
    1. vWA-like [53300] (5)
85. Pyruvate-ferredoxin oxidoreductase, PFOR, domain III [53322] (1)
    3 layers: a/b/a; mixed beta-sheet of 6 strands, order 231456; strand 3 is antiparallel to the rest
    1. Pyruvate-ferredoxin oxidoreductase, PFOR, domain III [53323] (1)
86. Ribose transport protein RbsD [102545] (1)
    3 layers: a/b/a; mixed beta-sheet of 6 strands, order 251634; strand 6 is antiparallel to the rest
    1. Ribose transport protein RbsD [102546] (1)
87. FabD/lysophospholipase-like [52150] (1)
    core: 3 layers, a/b/a; mixed beta-sheet of 6 strands, order 432156; strand 4 is antiparallel to the rest
    1. FabD/lysophospholipase-like [52151] (3)
88. L-sulfolactate dehydrogenase-like [89732] (1)
    core: 3 layers, a/b/a; mixed sheet of 7 strands, order 1237456; strands 1, 6 and 7 are antiparallel to the rest
    1. L-sulfolactate dehydrogenase-like [89733] (1)
       topological similarity to the domain 2 of TM1585
89. Formyltransferase [53327] (1)
    3 layers: a/b/a; mixed beta-sheet of 7 strands, order 3214567; strand 6 is antiparallel to the rest
    1. Formyltransferase [53328] (1)
90. S-adenosyl-L-methionine-dependent methyltransferases [53334] (1)
    core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest
    1. S-adenosyl-L-methionine-dependent methyltransferases [53335] (52)
91. LmbE-like [102587] (1)
    3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest; topological similarity to SAM-dependent methyltransferases
    1. LmbE-like [102588] (1)
92. PLP-dependent transferases [53382] (1)
    main domain: 3 layers: a/b/a, mixed beta-sheet of 7 strands, order 3245671; strand 7 is antiparallel to the rest
    1. PLP-dependent transferases [53383] (8)
93. Nucleotide-diphospho-sugar transferases [53447] (1)
    3 layers: a/b/a; mixed beta-sheet of 7 strands, order 3214657; strand 6 is antiparallel to the rest
    1. Nucleotide-diphospho-sugar transferases [53448] (15)
94. RibA-like [142694] (1)
    3 layers: a/b/a; mixed beta-sheet of 7 strands, order 1235467, strands 1 and 3 are antiparallel to the rest; partial topological similarity to some alpha/beta hydrolases (scop_cf 53473)
    1. RibA-like [142695] (1)
95. Activating enzymes of the ubiquitin-like proteins [69571] (1)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 32145678; strands 6 and 8 are antiparallel to the rest
    1. Activating enzymes of the ubiquitin-like proteins [69572] (2)
       transfer adenylyl group to the C-terminal carboxyl group of the ubiquitin and MoaD/ThiS-related proteins
       the ATP nucleotide-binding site is similar to that of the NAD-binding Rossmann-folds
96. alpha/beta-Hydrolases [53473] (1)
    core: 3 layers, a/b/a; mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest
    1. alpha/beta-Hydrolases [53474] (35)
       many members have left-handed crossover connection between strand 8 and additional strand 9
97. Nucleoside hydrolase [53589] (1)
    core: 3 layers, a/b/a ; mixed beta-sheet of 8 strands, order 32145687; strand 7 is antiparallel to the rest
    1. Nucleoside hydrolase [53590] (1)
98. Dihydrofolate reductase-like [53596] (1)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
    1. Dihydrofolate reductase-like [53597] (2)
99. Ribokinase-like [53612] (3)
    core: 3 layers: a/b/a; mixed beta-sheet of 8 strands, order 21345678, strand 7 is antiparallel to the rest
    potential superfamily: members of this fold have similar functions but different ATP-binding sites
    1. Ribokinase-like [53613] (5)
       has extra strand located between strands 2 and 3
    2. MurD-like peptide ligases, catalytic domain [53623] (2)
       has extra strand located between strands 1 and 2
    3. CoaB-like [102645] (1)
       combination of the Rossmann-like and Ribokinase-like topologies; mixed beta-sheet of 8 strands, order 32145678, strand 7 is antiparallel to the rest
100. YjeF N-terminal domain-like [64152] (1)
     3 layers: a/b/a; mixed (mainly parallel) beta-sheet of 8 strands, order 32145678; strand 8 is antiparallel to the rest
     1. YjeF N-terminal domain-like [64153] (1)
        possible circular permutation of the ribokinase-like fold (of the YjeF C-terminal domain)
101. Carbamate kinase-like [53632] (1)
     3 layers: a/b/a; mixed (mainly parallel) beta-sheet of 8 strands, order 34215786; strand 8 is antiparallel to the rest
     1. Carbamate kinase-like [53633] (3)
        the sheet topology is similar to those of undecaprenyl diphosphate synthase and the N-terminal domain of phosphoglycerate kinase
102. 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain [64157] (1)
     core:3 layers: a/b/a; mixed beta-sheet of 8 strands, order 45321678, strands 4 and 5 are antiparallel to the rest
     1. 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain [64158] (1)
103. Alkaline phosphatase-like [53648] (1)
     core:3 layers: a/b/a; mixed beta-sheet of 8 strands, order 43516728, strand 7 is antiparallel to the rest
     1. Alkaline phosphatase-like [53649] (5)
104. Hypothetical protein TT1679 [110709] (1)
     3 layers: a/b/a; mixed beta-sheet of 8 strands, order 78612354; strands 3, 4 and 8 are antiparallel to the rest
     1. Hypothetical protein TT1679 [110710] (1)
105. Glycerol-3-phosphate (1)-acyltransferase [69592] (1)
     3 layers: a/b/a; mixed beta-sheet of 9 strands, order 918736452; strands 1, 2 and 8 are antiparallel to the rest
     1. Glycerol-3-phosphate (1)-acyltransferase [69593] (1)
        some topological similarity to the dihydrofolate reductase fold
106. AraD-like aldolase/epimerase [53638] (1)
     3 layers: a/b/a; mixed (mostly antiparallel) beta-sheet of 9 strands, order 432159876; left-handed crossover between strands 4 and 5
     1. AraD-like aldolase/epimerase [53639] (1)
107. SurE-like [64166] (1)
     3 layers: a/b/a; mixed beta-sheet of 9 strands, order 342156798; strands 3, 8 and 9 are antiparallel to the rest; left-handed crossover connection between strands 6 and 7
     1. SurE-like [64167] (1)