Fold: TIM beta/alpha-barrel

contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
the first seven superfamilies have similar phosphate-binding sites

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b) [51349]
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: TIM beta/alpha-barrel [51350]
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

Superfamilies:

1. Triosephosphate isomerase (TIM) [51351] (1)
2. Ribulose-phoshate binding barrel [51366] (6)
3. Thiamin phosphate synthase [51391] (1)
4. Pyridoxine 5'-phosphate synthase [63892] (1)
5. FMN-linked oxidoreductases [51395] (1)
6. Inosine monophosphate dehydrogenase (IMPDH) [51412] (1)
   The phosphate moiety of substrate binds in the 'common' phosphate-binding site
7. PLP-binding barrel [51419] (2)
   circular permutation of the canonical fold: begins with an alpha helix and ends with a beta-strand
8. NAD(P)-linked oxidoreductase [51430] (1)
9. (Trans)glycosidases [51445] (14)
10. Metallo-dependent hydrolases [51556] (15)
    the beta-sheet barrel is similarly distorted and capped by a C-terminal helix
    has transition metal ions bound inside the barrel
11. Aldolase [51569] (8)
    Common fold covers whole protein structure
12. Enolase C-terminal domain-like [51604] (2)
    binds metal ion (magnesium or manganese) in conserved site inside barrel
    N-terminal alpha+beta domain is common to this superfamily
13. Phosphoenolpyruvate/pyruvate domain [51621] (6)
14. Malate synthase G [51645] (1)
15. RuBisCo, C-terminal domain [51649] (1)
16. Xylose isomerase-like [51658] (7)
    different families share similar but non-identical metal-binding sites
17. Bacterial luciferase-like [51679] (4)
    consists of clearly related families of somewhat different folds
18. Nicotinate/Quinolinate PRTase C-terminal domain-like [51690] (2)
    incomplete beta/alpha barrel with parallel beta-sheet of 7 strands
19. PLC-like phosphodiesterases [51695] (3)
20. Cobalamin (vitamin B12)-dependent enzymes [51703] (4)
21. tRNA-guanine transglycosylase [51713] (1)
22. Dihydropteroate synthetase-like [51717] (2)
23. UROD/MetE-like [51726] (2)
24. FAD-linked oxidoreductase [51730] (2)
    distinct cofactor-binding mode from both FMN- and NAD(P)-linked TIM-barrel oxidoreductases; families are related by a circular permutation
25. Monomethylamine methyltransferase MtmB [75098] (1)
26. Homocysteine S-methyltransferase [82282] (1)
27. (2r)-phospho-3-sulfolactate synthase ComA [102110] (1)
28. Radical SAM enzymes [102114] (3)
    common Fe-S cluster and SAM binding sites are embedded into complete or incomplete beta/alpha-barrel
29. GlpP-like [110391] (1)
30. CutC-like [110395] (1)
31. ThiG-like [110399] (1)
    shares the common phosphate-binding site with other superfamilies
32. TM1631-like [117396] (1)
33. EAL domain-like [141868] (1)
    variant of the beta/alpha-barrel fold with strand 1 being antiparallel to the rest

Generated from scop database 1.73 with scopm 1.101 on Wed Nov 21 11:18:32 2007 Copyright © 1994-2007 The scop authors / scop@mrc-lmb.cam.ac.uk