Structural Classification of Proteins
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Fold: NAD(P)-binding Rossmann-fold domains

core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: NAD(P)-binding Rossmann-fold domains [51734]
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamilies:

  1. NAD(P)-binding Rossmann-fold domains [51735] (12)
    1. Alcohol dehydrogenase-like, C-terminal domain [51736] (28)
      N-terminal all-beta domain defines family
      1. Alcohol dehydrogenase [51737]
        1. Horse (Equus caballus) [TaxId: 9796] [51738] (38) picpic
        2. Human (Homo sapiens), different isozymes [TaxId: 9606] [51739] (26) picpic
        3. Mouse (Mus musculus), class II [TaxId: 10090] [51740] (3) picpic
        4. Frog (Rana perezi) [TaxId: 8403] [89511] (2) picpic
        5. Cod (Gadus callarias) [TaxId: 8053] [51741] (1) picpic
        6. Archaeon Sulfolobus solfataricus [TaxId: 2287] [82286] (4) picpic
        7. Archaeon Aeropyrum pernix [TaxId: 56636] [102121] (1) picpic
        8. Pseudomonas aeruginosa [TaxId: 287] [102122] (1) picpic
        9. Bacillus stearothermophilus [TaxId: 1422] [102123] (1) picpic
      2. Hypothetical protein TM0436 [102124]
        1. Thermotoga maritima [TaxId: 2336] [102125] (1) picpic
      3. Hypothetical protein YhdH [102126]
        1. Escherichia coli [TaxId: 562] [102127] (2) picpic
      4. Hypothetical protein YahK [102128]
        1. Escherichia coli [TaxId: 562] [102129] (1) picpic
      5. Benzyl alcohol dehydrogenase [89512]
        1. Acinetobacter calcoaceticus [TaxId: 471] [89513] (1) picpic
      6. Bacterial secondary alcohol dehydrogenase [51742]
        1. Clostridium beijerinckii [TaxId: 1520] [51743] (3) picpic
        2. Thermoanaerobacter brockii [TaxId: 29323] [51744] (6) picpic
      7. Ketose reductase (sorbitol dehydrogenase) [51745]
        1. Silverleaf whitefly (Bemisia argentifolii) [TaxId: 77855] [51746] (1) picpic
        2. Human (Homo sapiens) [TaxId: 9606] [102130] (3) picpic
      8. Formaldehyde dehydrogenase [82287]
        1. Pseudomonas putida [TaxId: 303] [82288] (1) picpic
      9. Quinone oxidoreductase [51747]
        1. Escherichia coli [TaxId: 562] [51748] (1) picpic
        2. Thermus thermophilus [TaxId: 274] [89514] (2) picpic
        3. Human (Homo sapiens) [TaxId: 9606] [117402] (1) picpic
      10. Putative enoyl reductase domain of polyketide synthase [89515]
        1. Mycobacterium tuberculosis [TaxId: 1773] [89516] (1) picpic
      11. 2,4-dienoyl-CoA reductase [89517]
        1. Yeast (Candida tropicalis) [TaxId: 5482] [89518] (5) picpic
      12. Putative zinc-binding alcohol dehydrogenase [102131]
        1. Mouse (Mus musculus) [TaxId: 10090] [102132] (1) picpic
      13. Cinnamyl alcohol dehydrogenase, ADH6 [110403]
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [110404] (3) picpic
      14. Leukotriene b4 12-hydroxydehydrogenase/prostaglandin 15-keto reductase [110405]
        1. Guinea pig (Cavia porcellus) [TaxId: 10141] [110406] (5) picpic
      15. B. subtilis YhfP homologue [117403]
        1. Bacillus stearothermophilus [TaxId: 1422] [117404] (1) picpic
      16. Hypothetical protein YhfP [117405]
        1. Bacillus subtilis [TaxId: 1423] [117406] (2) picpic
    2. Tyrosine-dependent oxidoreductases [51751] (108)
      also known as short-chain dehydrogenases and SDR family
      parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
      1. Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase) [51752]
        1. Escherichia coli [TaxId: 562] [51753] (17) picpic
        2. Human (Homo sapiens) [TaxId: 9606] [51754] (7) picpic
        3. Trypanosoma brucei [TaxId: 5691] [89519] (5) picpic
        4. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [141872] (1) picpic
          N-terminal domain of bifunctional Gal10 protein
      2. dTDP-glucose 4,6-dehydratase (RmlB) [51755]
        1. Escherichia coli [TaxId: 562] [51756] (1) picpic
        2. Salmonella enterica [TaxId: 28901] [63925] (1) picpic
        3. Streptococcus suis, serotype 2 [TaxId: 1307] [69406] (6) picpic
        4. Streptomyces venezuelae [TaxId: 54571] [102133] (2) picpic
      3. dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD) [75102]
        1. Salmonella enterica serovar typhimurium [TaxId: 90371] [75103] (4) picpic
      4. GDP-4-keto-6-deoxy-d-mannose epimerase/reductase (GDP-fucose synthetase) [51757]
        1. Escherichia coli [TaxId: 562] [51758] (8) picpic
      5. GDP-mannose 4,6-dehydratase [51759]
        1. Escherichia coli [TaxId: 562] [51760] (1) picpic
        2. Pseudomonas aeruginosa [TaxId: 287] [102134] (1) picpic
        3. Human (Homo sapiens) [TaxId: 9606] [102135] (1) picpic
        4. Thale-cress (Arabidopsis thaliana) [TaxId: 3702] [82289] (2) picpic
      6. ADP-L-glycero-D-mannoheptose 6-epimerase [51761]
        1. Escherichia coli [TaxId: 562] [51762] (1) picpic
      7. CDP-glucose-4,6-dehydratase [102136]
        1. Yersinia pseudotuberculosis [TaxId: 633] [102137] (1) picpic
        2. Salmonella typhimurium [TaxId: 602] [141873] (2) picpic
      8. CDP-tyvelose-2-epimerase [102138]
        1. Salmonella typhi [TaxId: 601] [102139] (1) picpic
      9. Phenylcoumaran benzylic ether reductase [102140]
        1. Loblolly pine (Pinus taeda) [TaxId: 3352] [102141] (1) picpic
      10. Pinoresinol-lariciresinol reductase [102142]
        1. Giant arborvitae (Thuja plicata) [TaxId: 3316] [102143] (1) picpic
      11. Sulfolipid biosynthesis protein SQD1 [51763]
        1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [51764] (4) picpic
      12. Negative transcriptional regulator NmrA [69407]
        has an UDP-galactose 4-epimerase-like structure but evolved a different function
        1. Aspergillus nidulans [TaxId: 162425] [69408] (5) picpic
      13. Carbonyl reductase [51765]
        1. Mouse (Mus musculus) [TaxId: 10090] [51766] (1) picpic
        2. Human (Homo sapiens) [TaxId: 9606] [102144] (5) picpic
          dicarbonyl/L-xylulose reductase
      14. Sepiapterin reductase [51767]
        1. Mouse (Mus musculus) [TaxId: 10090] [51768] (3) picpic
        2. Human (Homo sapiens) [TaxId: 9606] [141874] (6) picpic
      15. Dihydropteridin reductase (pteridine reductase) [51769]
        1. Rat (Rattus norvegicus) [TaxId: 10116] [51770] (2) picpic
        2. Human (Homo sapiens) [TaxId: 9606] [51771] (1) picpic
        3. Leishmania major [TaxId: 5664] [63926] (23) picpic
        4. Leishmania tarentolae [TaxId: 5689] [102145] (1) picpic
        5. Trypanosoma cruzi [TaxId: 5693] [102146] (2) picpic
        6. Nematode (Caenorhabditis elegans) [TaxId: 6239] [89520] (1) picpic
      16. Human estrogenic 17beta-hydroxysteroid dehydrogenase [51772]
        1. Human (Homo sapiens) [TaxId: 9606] [51773] (16) picpic
      17. 7-alpha-hydroxysteroid dehydrogenase [51774]
        1. Escherichia coli [TaxId: 562] [51775] (3) picpic
      18. 3-alpha,20-beta-hydroxysteroid dehydrogenase [51776]
        1. Streptomyces hydrogenans [TaxId: 1905] [51777] (2) picpic
      19. 3-alpha-hydroxysteroid dehydrogenase [51778]
        1. Comamonas testosteroni [TaxId: 285] [51779] (2) picpic
      20. 3beta/17beta hydroxysteroid dehydrogenase [82290]
        1. Comamonas testosteroni [TaxId: 285] [82291] (1) picpic
      21. Putative oxidoreductase Rv2002 [82292]
        1. Mycobacterium tuberculosis [TaxId: 1773] [82293] (3) picpic
      22. R-specific alcohol dehydrogenase [89521]
        1. Lactobacillus brevis [TaxId: 1580] [89522] (15) picpic
      23. Cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase [51780]
        1. Pseudomonas sp., lb400 [TaxId: 306] [51781] (1) picpic
      24. Drosophila alcohol dehydrogenase [51782]
        1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [102147] (1) picpic
        2. Fly (Drosophila lebanonensis) [TaxId: 7225] [51783] (7) picpic
      25. Glucose dehydrogenase [51784]
        1. Bacillus megaterium [TaxId: 1404] [51785] (4) picpic
      26. Sorbitol dehydrogenase [102148]
        1. Rhodobacter sphaeroides [TaxId: 1063] [102149] (1) picpic
      27. meso-2,3-butanediol dehydrogenase [51786]
        1. Klebsiella pneumoniae [TaxId: 573] [51787] (1) picpic
      28. Levodione reductase [89523]
        1. Corynebacterium aquaticum [TaxId: 144185] [89524] (1) picpic
      29. Mannitol dehydrogenase [63927]
        1. Mushroom (Agaricus bisporus) [TaxId: 5341] [63928] (1) picpic
      30. (3R)-hydroxyacyl-CoA dehydrogenase domain of estradiol 17 beta-Dehydrogenase 4 [82294]
        peroxisomal multifunctional enzyme type 2
        segment swapping involving a C-terminal extension to the family fold
        1. Rat (Rattus norvegicus) [TaxId: 10116] [82295] (1) picpic
      31. beta-keto acyl carrier protein reductase [51788]
        1. Oil seed rape (Brassica napus) [TaxId: 3708] [51789] (7) picpic
        2. Escherichia coli [TaxId: 562] [51790] (3) picpic
        3. Thermotoga maritima [TaxId: 2336] [102150] (1) picpic
          TM1169
        4. Thermus thermophilus [TaxId: 274] [117407] (1) picpic
        5. Streptomyces coelicolor [TaxId: 1902] [117408] (5) picpic
        6. Mycobacterium tuberculosis [TaxId: 1773] [141875] (6) picpic
        7. Thermus thermophilus, TTHB020 [TaxId: 274] [141876] (2) picpic
        8. Malaria parasite (Plasmodium falciparum) [TaxId: 5833] [141877] (1) picpic
      32. Enoyl-ACP reductase [51791]
        1. Oil seed rape (Brassica napus) [TaxId: 3708] [51792] (4) picpic
        2. Malaria parasite (Plasmodium falciparum) [TaxId: 5833] [82296] (19) picpic
        3. Mycobacterium tuberculosis, TB, gene InhA [TaxId: 1773] [51793] (35) picpic
        4. Escherichia coli [TaxId: 562] [51794] (14) picpic
        5. Helicobacter pylori [TaxId: 210] [102151] (8) picpic
        6. Thermus thermophilus [TaxId: 274] [117409] (9) picpic
      33. Tropinone reductase [51795]
        1. Jimsonweed (Datura stramonium), I [TaxId: 4076] [51796] (1) picpic
        2. Jimsonweed (Datura stramonium), II [TaxId: 4076] [51797] (4) picpic
        3. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [117410] (2) picpic
      34. 1,3,8-trihydroxynaphtalene reductase (THNR, naphtol reductase) [51798]
        1. Rice blast fungus (Magnaporthe grisea) [TaxId: 148305] [51799] (4) picpic
      35. 1,3,6,8-tetrahydroxynaphthalene reductase [63929]
        1. Rice blast fungus (Magnaporthe grisea) [TaxId: 148305] [63930] (1) picpic
      36. Biliverdin IX beta reductase [63931]
        Histidine in the active site instead of the Tyr-Lys dyad
        1. Human (Homo sapiens) [TaxId: 9606] [63932] (5) picpic
      37. Type II 3-hydroxyacyl-CoA dehydrogenase [63933]
        1. Rat (Rattus norvegicus) [TaxId: 10116] [63934] (3) picpic
        2. Human (Homo sapiens) [TaxId: 9606] [102152] (4) picpic
        3. Thermus thermophilus [TaxId: 274] [89525] (1) picpic
      38. Carbonyl reductase/20beta-hydroxysteroid dehydrogenase [63935]
        1. Pig (Sus scrofa) [TaxId: 9823] [63936] (1) picpic
        2. Human (Homo sapiens) [TaxId: 9606] [141878] (1) picpic
      39. Halohydrin dehalogenase HheC [102153]
        haloalcohol dehalogenase: evolved a new activity; lost the NAD-binding site
        1. Agrobacterium tumefaciens [TaxId: 358] [102154] (23) picpic
      40. Glucose dehydrogenase (5l265) [102155]
        1. Nematode (Caenorhabditis elegans) [TaxId: 6239] [102156] (1) picpic
      41. UDP-N-acetylglucosamine 4-epimerase WbpP [110407]
        1. Pseudomonas aeruginosa [TaxId: 287] [110408] (2) picpic
      42. DTDP-4-dehydrorhamnose reductase RfbD [110409]
        1. Clostridium acetobutylicum [TaxId: 1488] [110410] (1) picpic
      43. Gluconate 5-dehydrogenase [110411]
        1. Thermotoga maritima [TaxId: 2336] [110412] (1) picpic
      44. Carbonyl reductase sniffer [110413]
        1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [110414] (1) picpic
      45. Hypothetical protein F25D1.5 [110415]
        1. Caenorhabditis elegans [TaxId: 6239] [110416] (1) picpic
      46. Putative dehydrogenase ARPG836 (MGC4172) [117411]
        1. Human (Homo sapiens) [TaxId: 9606] [117412] (1) picpic
      47. Aldehyde reductase II [117413]
        1. Sporobolomyces salmonicolor [TaxId: 5005] [117414] (5) picpic
      48. Hypothetical protein R05D8.7 [117415]
        1. Caenorhabditis elegans [TaxId: 6239] [117416] (1) picpic
      49. Hypothetical protein At5g02240 (T7H20_290) [117417]
        1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [117418] (7) picpic
      50. Polymyxin resistance protein ArnA (PrmI) [117419]
        evolved new activities: UDP-glucuronic acid decarboxylase, UDP-4-amino-4-deoxy-L-arabinose formyltransferase
        1. Escherichia coli [TaxId: 562] [117420] (12) picpic
      51. 2,4-dienoyl-CoA reductase, mitochondrial (DECR) [117421]
        1. Human (Homo sapiens), [TaxId: 9606] [117422] (3) picpic
      52. 11-beta-hydroxysteroid dehydrogenase 1 [117423]
        1. Human (Homo sapiens) [TaxId: 9606] [117424] (11) picpic
        2. Guinea pig (Cavia porcellus) [TaxId: 10141] [117425] (1) picpic
        3. Mouse (Mus musculus) [TaxId: 10090] [141879] (4) picpic
      53. 17-beta-hydroxysteroid dehydrogenase type XI [117426]
        1. Human (Homo sapiens) [TaxId: 9606] [117427] (1) picpic
      54. UDP-glucuronate decarboxylase 1 [141880]
        1. Human (Homo sapiens) [TaxId: 9606] [141881] (1) picpic
      55. Xylitol dehydrogenase [141882]
        1. Gluconobacter oxydans [TaxId: 442] [141883] (8) picpic
      56. Peroxisomal trans 2-enoyl CoA reductase [141884]
        1. Human (Homo sapiens) [TaxId: 9606] [141885] (4) picpic
      57. D(-)-3-hydroxybutyrate dehydrogenase [141886]
        1. Pseudomonas fragi [TaxId: 296] [141887] (3) picpic
      58. 15-hydroxyprostaglandin dehydrogenase, PGDH [141888]
        1. Human (Homo sapiens) [TaxId: 9606] [141889] (1) picpic
      59. GDP-mannose-3', 5'-epimerase [141890]
        1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [141891] (8) picpic
      60. Bacterial sepiapterin reductase [141892]
        1. Chlorobium tepidum [TaxId: 1097] [141893] (4) picpic
          CT0609
      61. Dehydrogenase/reductase SDR family member 6, DHRS6 [141894]
        Oxidoreductase UCPA
        1. Human (Homo sapiens) [TaxId: 9606] [141895] (4) picpic
      62. Hypothetical protein TTHA0369 [141896]
        TT0321
        1. Thermus thermophilus [TaxId: 274] [141897] (4) picpic
      63. Rhizome secoisolariciresinol dehydrogenase [141898]
        1. Mayapple (Podophyllum peltatum) [TaxId: 35933] [141899] (4) picpic
      64. Peroxisomal multifunctional enzyme type 2 [141900]
        17-beta-hydroxysteroid dehydrogenase 4
        1. Human (Homo sapiens) [TaxId: 9606] [141901] (6) picpic
          the structure of C-terminal domain is also known, PDB entry 1S9C
      65. (s)-1-phenylethanol dehydrogenase [141902]
        1. Azoarcus sp. ebn1 [TaxId: 76114] [141903] (6) picpic
      66. TAT-interacting protein TIP30 [141904]
        1. Human (Homo sapiens) [TaxId: 9606] [141905] (1) picpic
        2. Mouse (Mus musculus) [TaxId: 10090] [141906] (1) picpic
      67. Retinal dehydrogenase/reductase 3 [141907]
        1. Human (Homo sapiens) [TaxId: 9606] [141908] (16) picpic
      68. Erythromycin synthase, eryAI, 1st ketoreductase module [141909]
        tandem repeat of two SDR-like modules resembling a dimer commonly founf in the family; only the second module retains the coenzyme-binding site
        1. Saccharopolyspora erythraea [TaxId: 1836] [141910] (4) picpic
      69. Hypothetical protein PA4017 [141911]
        unknown function; the active site region is blocked by a loop; strong sequence similarity to mammalian TAT-interacting protein TIP30
        1. Pseudomonas aeruginosa [TaxId: 287] [141912] (2) picpic
      70. Putative carbonyl reductase sniffer [141913]
        1. Caenorhabditis elegans [TaxId: 6239] [141914] (6) picpic
    3. Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain [51800] (51)
      family members also share a common alpha+beta fold in C-terminal domain
      1. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) [51801]
        1. Escherichia coli [TaxId: 562] [51802] (7) picpic
        2. Bacillus stearothermophilus, nca 1503 [TaxId: 1422] [51803] (10) picpic
        3. Achromobacter xylosoxidans [TaxId: 85698] [89526] (1) picpic
          formerly Alcaligenes xylosoxidans
        4. Thermus aquaticus [TaxId: 271] [51804] (13) picpic
        5. Thermus thermophilus [TaxId: 274] [102157] (1) picpic
        6. Thermotoga maritima [TaxId: 2336] [51805] (1) picpic
        7. Archaeon Sulfolobus solfataricus [TaxId: 2287] [51806] (1) picpic
        8. Archaeon Methanothermus fervidus [TaxId: 2180] [51807] (1) picpic
        9. Trypanosoma brucei brucei, glycosome [TaxId: 5702] [51808] (1) picpic
        10. Trypanosoma cruzi [TaxId: 5693] [75104] (3) picpic
        11. Leishmania mexicana [TaxId: 5665] [51809] (5) picpic
        12. American lobster (Homarus americanus) [TaxId: 6706] [51810] (2) picpic
        13. South China Sea lobster (Palinurus versicolor) [TaxId: 82835] [51811] (5) picpic
        14. Human (Homo sapiens) [TaxId: 9606] [51812] (1) picpic
        15. Rabbit (Oryctolagus cuniculus) [TaxId: 9986] [102158] (1) picpic
        16. Spinach (Spinacia oleracea) [TaxId: 3562] [69409] (21) picpic
        17. Human(Homo sapiens), liver isoform [TaxId: 9606] [141915] (8) picpic
        18. Malaria parasite (Plasmodium falciparum) [TaxId: 5833] [141916] (12) picpic
      2. Aspartate beta-semialdehyde dehydrogenase [51813]
        1. Escherichia coli [TaxId: 562] [51814] (4) picpic
        2. Vibrio cholerae [TaxId: 666] [82297] (2) picpic
        3. Haemophilus influenzae [TaxId: 727] [102159] (12) picpic
        4. Streptococcus pneumoniae [TaxId: 1313] [141917] (11) picpic
      3. Acetaldehyde dehydrogenase (acylating) [89527]
        1. Pseudomonas sp. [TaxId: 306] [89528] (1) picpic
      4. Homoserine dehydrogenase [51815]
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [51816] (4) picpic
      5. Saccharopine reductase [51817]
        1. Rice blast fungus (Magnaporthe grisea) [TaxId: 148305] [51818] (3) picpic
      6. Diaminopimelic acid dehydrogenase (DAPDH) [51819]
        1. Corynebacterium glutamicum [TaxId: 1718] [51820] (4) picpic
      7. Dihydrodipicolinate reductase [51821]
        1. Escherichia coli [TaxId: 562] [51822] (5) picpic
        2. Mycobacterium tuberculosis [TaxId: 1773] [102160] (14) picpic
        3. Thermotoga maritima [TaxId: 2336] [110417] (1) picpic
      8. Myo-inositol 1-phosphate synthase [75105]
        1. Mycobacterium tuberculosis [TaxId: 1773] [75106] (1) picpic
        2. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [75107] (9) picpic
        3. Archaeoglobus fulgidus [TaxId: 2234] [110418] (1) picpic
        4. Caenorhabditis elegans [TaxId: 6239] [110419] (1) picpic
      9. Hypothetical protein TM1419 [102161]
        myo-inositol 1-phosphate synthase-related protein
        1. Thermotoga maritima [TaxId: 2336] [102162] (1) picpic
      10. Hypothetical protein TM1643 [75108]
        1. Thermotoga maritima [TaxId: 2336] [75109] (2) picpic
      11. 1-deoxy-D-xylulose-5-phosphate reductoisomerase [69410]
        1. Escherichia coli [TaxId: 562] [69411] (12) picpic
        2. Zymomonas mobilis [TaxId: 542] [110420] (2) picpic
      12. Biliverdin reductase [51823]
        1. Rat (Rattus norvegicus) [TaxId: 10116] [51824] (3) picpic
      13. Glucose-fructose oxidoreductase, N-terminal domain [51825]
        1. Zymomonas mobilis [TaxId: 542] [51826] (12) picpic
      14. Glucose 6-phosphate dehydrogenase, N-terminal domain [51827]
        1. Leuconostoc mesenteroides [TaxId: 1245] [51828] (9) picpic
        2. Human (Homo sapiens) [TaxId: 9606] [51829] (1) picpic
      15. Virulence factor MviM [110421]
        1. Escherichia coli [TaxId: 562] [110422] (1) picpic
      16. N-acetyl-gamma-glutamyl-phosphate reductase ArgC [110423]
        1. Thermotoga maritima [TaxId: 2336] [110424] (1) picpic
        2. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [117428] (5) picpic
        3. Salmonella typhimurium [TaxId: 602] [141918] (1) picpic
      17. Putative oxidoreductase VCA1048 [110425]
        1. Vibrio cholerae [TaxId: 666] [110426] (1) picpic
      18. Probable oxidoreductase At4g09670 [117429]
        1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [117430] (1) picpic
      19. Putative semialdehyde dehydrogenase [141919]
        1. Rice (Oryza sativa) [TaxId: 4530] [141920] (4) picpic
      20. Galactose/lactose metabolism regulatory protein GAL80 [141921]
        1. Yeast (Kluyveromyces lactis) [TaxId: 28985] [141922] (1) picpic
      21. Usg-1 protein homolog PA3116 [141923]
        1. Pseudomonas aeruginosa [TaxId: 287] [141924] (1) picpic
      22. Hypothetical protein TM0312 [141925]
        1. Thermotoga maritima [TaxId: 2336] [141926] (2) picpic
    4. Formate/glycerate dehydrogenases, NAD-domain [51830] (14)
      this domain interrupts the other domain which defines family
      1. Formate dehydrogenase [51831]
        1. Pseudomonas sp., strain 101 [TaxId: 306] [51832] (2) picpic
      2. Putative formate dehydrogenase [51833]
        1. Archaeon Pyrobaculum aerophilum [TaxId: 13773] [51834] (1) picpic
      3. Transcription corepressor CtbP [82298]
        C-terminal binding protein 1; a dehydrogenase
        1. Human (Homo sapiens), Ctbp1 [TaxId: 9606] [82299] (1) picpic
        2. Rat (Rattus norvegicus), Ctbp3 [TaxId: 10116] [89529] (2) picpic
      4. D-2-hydroxyisocaproate dehydrogenase [51835]
        1. Lactobacillus casei [TaxId: 1582] [51836] (1) picpic
      5. D-glycerate dehydrogenase [51837]
        1. Hyphomicrobium methylovorum [TaxId: 84] [51838] (1) picpic
      6. Phosphoglycerate dehydrogenase [51839]
        has additional C-terminal domain of the ferredoxin fold
        1. Escherichia coli [TaxId: 562] [51840] (18) picpic
        2. Mycobacterium tuberculosis [TaxId: 1773] [141927] (2) picpic
      7. D-lactate dehydrogenase [51841]
        1. Lactobacillus helveticus [TaxId: 1587] [51842] (3) picpic
      8. L-alanine dehydrogenase [51843]
        1. Phormidium lapideum [TaxId: 32060] [51844] (3) picpic
      9. Nicotinamide nucleotide transhydrogenase dI component [63937]
        L-alanine dehydrogenase homologue
        1. Rhodospirillum rubrum [TaxId: 1085] [63938] (28) picpic
      10. S-adenosylhomocystein hydrolase [51845]
        1. Human (Homo sapiens) [TaxId: 9606] [51846] (2) picpic
        2. Rat (Rattus norvegicus) [TaxId: 10116]