Structural Classification of Proteins
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Fold: Rhodanese/Cell cycle control phosphatase

3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32451

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: Rhodanese/Cell cycle control phosphatase [52820]
    3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32451

Superfamilies:

  1. Rhodanese/Cell cycle control phosphatase [52821] (4)
    Pfam 00581
    the active site structure is similar to those of the families I and II protein phosphatases; the topology can be related by a different circular permutation to the family I topology
    1. Cell cycle control phosphatase, catalytic domain [52822] (4)
      1. CDC25a [52823]
        1. Human (Homo sapiens) [TaxId: 9606] [52824] (1) picpic
      2. CDC25b [52825]
        1. Human (Homo sapiens) [TaxId: 9606] [52826] (9) picpic
      3. Erk2 binding domain of Mapk phosphatase mkp-3 [69507]
        1. Human (Homo sapiens) [TaxId: 9606] [69508] (1) picpic
      4. Dual specificity phosphatase Cdc25 [110598]
        1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [110599] (1) picpic
    2. Single-domain sulfurtransferase [69509] (3)
      1. Sulfurtransferase GlpE [69510]
        single-domain rhodanese
        1. Escherichia coli [TaxId: 562] [69511] (2) picpic
      2. Polysulfide-sulfur transferase (sulfide dehydrogenase, Sud) [102425]
        1. Wolinella succinogenes [TaxId: 844] [102426] (1) picpic
      3. Thiosulfate sulfurtransferase/Senescence-associated protein [110600]
        1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [110601] (1) picpic
    3. Multidomain sulfurtransferase (rhodanese) [52827] (6)
      duplication: consists of two domains of this fold
      1. Rhodanese [52828]
        1. Cow (Bos taurus) [TaxId: 9913] [52829] (7) picpic
      2. Sulfurtransferase [52830]
        1. Azotobacter vinelandii [TaxId: 354] [52831] (3) picpic
        2. Thermus thermophilus [TaxId: 274] [110602] (1) picpic
      3. 3-mercaptopyruvate sulfurtransferase [102427]
        1. Leishmania major [TaxId: 5664] [102428] (1) picpic
        2. Escherichia coli [TaxId: 562] [102429] (1) picpic
      4. Thiosulfate sulfurtransferase PA2603 [142351]
        1. Pseudomonas aeruginosa [TaxId: 287] [142352] (4) picpic
    4. Ubiquitin carboxyl-terminal hydrolase 8, USP8 [117586] (1)
      1. Ubiquitin carboxyl-terminal hydrolase 8, USP8 [117587]
        1. Human (Homo sapiens) [TaxId: 9606] [117588] (4) picpic
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MRC site Generated from scop database 1.73 with scopm 1.101 on Wed Nov 21 11:18:32 2007
Copyright © 1994-2007 The scop authors / scop@mrc-lmb.cam.ac.uk