Structural Classification of Proteins

Class: Alpha and beta proteins (a+b)

: Mainly antiparallel beta sheets (segregated alpha and beta regions)

Lineage:

Root: scop
Class: Alpha and beta proteins (a+b) [53931]
Mainly antiparallel beta sheets (segregated alpha and beta regions)

Folds:

Microbial ribonucleases [53932] (1)
single helix packs against antiparallel beta-sheet
1. Microbial ribonucleases [53933] (3)
  1. Bacterial ribonucleases [81307] (5)
  2. Fungal ribonucleases [81311] (5)
  3. Ribotoxin [81310] (2)
    the fungal cytotoxic ribonucleases with many insertions in the common fold
Lysozyme-like [53954] (1)
common alpha+beta motif for the active site region
1. Lysozyme-like [53955] (7)
  1. Family 19 glycosidase [53956] (2)
  2. C-type lysozyme [53960] (20)
  3. Phage lysozyme [53981] (3)
  4. Lambda lysozyme [53984] (1)
  5. G-type lysozyme [53987] (2)
  6. Bacterial muramidase, catalytic domain [53991] (2)
    the large N-terminal domain is all-alpha superhelix
  7. Chitosanase [53996] (2)
Cysteine proteinases [54000] (1)
consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn
1. Cysteine proteinases [54001] (16)
  the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet
  1. Papain-like [54002] (30)
  2. Avirulence protein Avrpph3 [102723] (1)
  3. FMDV leader protease [54037] (1)
  4. Calpain large subunit, catalytic domain (domain II) [54040] (5)
  5. Transglutaminase core [54044] (5)
  6. Arylamine N-acetyltransferase [54047] (4)
    fold similar to that of the factor XIII catalytic domain
  7. Ubiquitin carboxyl-terminal hydrolase UCH-L [54050] (3)
  8. Ubiquitin carboxyl-terminal hydrolase, UCH [82568] (4)
    Pfam 00443
  9. Adenain-like [54054] (5)
    Pfam 02902; Ulp1 protease family
  10. Microbial transglutaminase [75336] (1)
    inverted positions of the catalytic triad Asp and His residues
  11. Ubiquitin thiolesterase protein OTUB2 (Otubain-2) [110773] (1)
    probably the same as Pfam 02338, OTU-like cysteine protease, but 1TFF (SQ Q96DC9) was not detected by the Pfam model
  12. IgG-specific endopeptidase IdeS (Sib38) [117762] (1)
  13. Lpg0564-like [142864] (1)
    Pfam 07313, DUF1460; contains new PDB entry 2p1g, annotated as putative xylanase
  14. Phytochelatin synthase [142867] (1)
    Pfam 05023; assosiated Pfam 09328 (DUF1984) is a part of the same functional unit
  15. CHAP domain [142870] (1)
    Pfam 05257
  16. NlpC/P60 [142873] (1)
    Pfam 00877
His-Me finger endonucleases [54059] (1)
core: (alpha)-beta-omega_loop-beta-alpha; embeded in larger different structures
1. His-Me finger endonucleases [54060] (6)
  common motif contains conserved histidine residue and metal-binding site
  1. Endonuclease I [102726] (1)
  2. HNH-motif [54061] (2)
  3. Sm endonuclease [54066] (1)
    the core motif is inserted in a six-stranded meander beta-sheet domain
  4. Intron-encoded homing endonucleases [54069] (2)
  5. Recombination endonuclease VII, N-terminal domain [68915] (1)
  6. Caspase-activated DNase, CAD (DffB, DFF40) [110778] (1)
RNase A-like [54075] (1)
contains long curved beta-sheet and 3 helices
1. RNase A-like [54076] (1)
  can be classified as disulfide-rich
  1. Ribonuclease A-like [54077] (15)
EndoU-like [142876] (1)
comprises several helices and two three-stranded antiparallel beta-sheets; similar architecture to the RNase A-like fold (scop_cf 54075)
1. EndoU-like [142877] (2)
  similarity to the RNase A-like superfamily (scop_sf 54076) extends to the active site location and architecture; the two structural cores of the RNase A and EndoU superfamilies are interrelated by a topological permutation - transposition of two pereferial beta-strands, suggesting possible distant homology of the two superfamilies (and their unification in a hyperfamily)
  1. Eukaryotic EndoU ribonuclease [142878] (1)
    PfamB 010233; common fold decorated with additional structures
  2. Nsp15 C-terminal domain-like [142881] (2)
    PfamB 001946
Prion-like [54097] (1)
beta-alpha-beta-alpha(2); antiparallel beta-ribbon
1. Prion-like [54098] (1)
  1. Prion-like [54099] (14)
LysM domain [54105] (1)
beta-alpha(2)-beta; antiparallel strands
1. LysM domain [54106] (1)
  1. LysM domain [54107] (2)
Head-to-tail joining protein W, gpW [64209] (1)
alpha-beta(2)-alpha; antiparallel hairpin
1. Head-to-tail joining protein W, gpW [64210] (1)
  1. Head-to-tail joining protein W, gpW [64211] (1)
Hypothetical protein MTH677 [110782] (1)
alpha-beta(2)-alpha; 2 layers a/b; antiparallel beta-hairpin
1. Hypothetical protein MTH677 [110783] (1)
  1. Hypothetical protein MTH677 [110784] (1)
GTF2I-like repeat [117772] (1)
alpha(2)-beta-alpha-beta-alpha; 2 layers: a/b; antiparallel beta-ribbon
1. GTF2I-like repeat [117773] (1)
  1. GTF2I-like repeat [117774] (1)
    Pfam 02946
Urease, gamma-subunit [54110] (1)
alpha(3)-beta(2); antiparallel hairpin
1. Urease, gamma-subunit [54111] (1)
  1. Urease, gamma-subunit [54112] (3)
IL8-like [54116] (2)
beta(3)-alpha
1. Interleukin 8-like chemokines [54117] (1)
  form dimers with different dimerisation modes
  1. Interleukin 8-like chemokines [54118] (29)
2. PhtA domain-like [142887] (1)
  contains extra N-terminal beta-hairpin, like structurally similar archaeal "histone-like" proteins (scop_fa 54161), but does not adopt its SH3-like barrel fold
  1. PhtA domain-like [142888] (1)
    Pfam 04270; Streptococcal histidine triad protein
DNA-binding domain [54170] (1)
beta(3)-alpha; 2 layers: alpha/beta
1. DNA-binding domain [54171] (4)
  1. DNA-binding domain from tn916 integrase [54172] (1)
  2. lambda integrase N-terminal domain [75344] (1)
  3. GCC-box binding domain [54175] (1)
  4. Methyl-CpG-binding domain, MBD [54178] (3)
Penicillin-binding protein 2x (pbp-2x), c-terminal domain [54183] (1)
alpha1-beta3; 2 layers: alpha/beta; order 132
1. Penicillin-binding protein 2x (pbp-2x), c-terminal domain [54184] (1)
  duplication: consists of 2 subdomains of this fold
  1. Penicillin-binding protein 2x (pbp-2x), c-terminal domain [54185] (1)
Dodecin subunit-like [88797] (5)
beta-alpha-beta(2); 2 layers: alpha/beta; antiparallel beta-sheet: order 132
1. Flavin-binding protein dodecin [89807] (1)
  1. Flavin-binding protein dodecin [89808] (1)
    Subunit assembly and a probable biological unit is a dodecamer, hence the name
2. Amyloid beta a4 protein copper binding domain (domain 2) [89811] (1)
  1. Amyloid beta a4 protein copper binding domain (domain 2) [89812] (1)
3. N-terminal, heterodimerisation domain of RBP7 (RpoE) [88798] (1)
  1. N-terminal, heterodimerisation domain of RBP7 (RpoE) [88799] (3)
4. D-lysine 5,6-aminomutase beta subunit KamE, N-terminal domain [117778] (1)
  1. D-lysine 5,6-aminomutase beta subunit KamE, N-terminal domain [117779] (1)
5. YbjQ-like [117782] (1)
  pentamer, beta/alpha-propeller; additional short beta-strands promote oligomeric assembly
  1. YbjQ-like [117783] (2)
    Pfam 01906; DUF 74, UPF0145
Ribosomal proteins S24e, L23 and L15e [54188] (1)
beta-(alpha)-beta-alpha-beta(2); 3 layers: alpha/beta/alpha; antiparallel beta-sheet: order 1243
1. Ribosomal proteins S24e, L23 and L15e [54189] (3)
  1. L23p [54190] (2)
  2. L15e [54193] (1)
    elaborated with additional structures
  3. Ribosomal protein S24e [117786] (3)
    Pfam 01282
Ribosome binding domain-like [100965] (2)
beta-(2)-alpha(2)-beta(2); 2 layers: beta/alpha; antiparallel beta-sheet: order 1243; topological similarity to the common core of ribosomal proteins L23 and L15e
1. Trigger factor ribosome-binding domain [102735] (1)
  1. Trigger factor ribosome-binding domain [102736] (2)
2. Translation initiation factor 2 beta, aIF2beta, N-terminal domain [100966] (1)
  1. Translation initiation factor 2 beta, aIF2beta, N-terminal domain [100967] (2)
TFB5-like [142896] (1)
beta-alpha-beta(2)-alpha; 2 layers, a/b; antiparallel sheet, order: 132; dimerises in solution (PDB 2jnj) via extended N-terminal strand
1. TFB5-like [142897] (1)
  1. TFB5-like [142898] (1)
    Pfam 06331
Obg GTP-binding protein C-terminal domain [102740] (1)
beta-(2)-alpha(3)-beta(2); 2 layers: beta/alpha; mixed beta-sheet: order 1234; strands 2 and 3 a parallel to each other
1. Obg GTP-binding protein C-terminal domain [102741] (1)
  1. Obg GTP-binding protein C-terminal domain [102742] (1)
HIT-like [54196] (2)
alpha-beta(3)-alpha-beta(2); 3 layers: alpha/beta/alpha
1. HIT-like [54197] (3)
  1. HIT (HINT, histidine triad) family of protein kinase-interacting proteins [54198] (6)
    Pfam 01230
    topologically similar to the N-terminal domain of protein kinases
  2. Hexose-1-phosphate uridylyltransferase [54207] (2)
    duplication: consists of 2 HIT-like motifs
    binds zinc and iron ions
  3. mRNA decapping enzyme DcpS C-terminal domain [102745] (2)
2. Rotavirus NSP2 fragment, C-terminal domain [75347] (1)
  1. Rotavirus NSP2 fragment, C-terminal domain [75348] (1)
Secretion chaperone-like [69634] (3)
alpha-beta(3)-alpha-beta(2)-alpha; 2 layers: alpha/beta
1. Type III secretory system chaperone [69635] (1)
  1. Type III secretory system chaperone [69636] (11)
    the family sequences are very divergent
2. Arp2/3 complex subunits [69645] (1)
  1. Arp2/3 complex subunits [69646] (2)
3. YjbR-like [142906] (1)
  overall similar to the Type III secretory system chaperone subunits; different shape of the beta-sheet
  1. YjbR-like [142907] (2)
    Pfam 04237; DUF419
DNA-binding domain of intron-encoded endonucleases [64495] (1)
beta(2)-alpha(2)-beta; 2 layers; 3-stranded antiparallel beta-sheet, order 213; HTH motif; also includes the extra N-terminal, DNA minor groove-binding helix
1. DNA-binding domain of intron-encoded endonucleases [64496] (1)
  1. DNA-binding domain of intron-encoded endonucleases [64497] (2)
MotA C-terminal domain-like [69651] (1)
alpha-beta(4)-alpha-beta(2)-alpha; 2 layers: alpha/beta
1. DNA-binding C-terminal domain of the transcription factor MotA [69652] (1)
  1. DNA-binding C-terminal domain of the transcription factor MotA [69653] (1)
YktB/PF0168-like [142912] (1)
alpha-beta(4)-alpha-beta(2)-alpha-beta-alpha; 2 layers, a/b; antiparallel beta-sheet, order: 1234756; half-barrel shape; topological similarity to the MotA C-terminal domain-like fold (scop_cf 69651) and the Secretion chaperone-like fold (scop_cf 69634)
1. YktB/PF0168-like [142913] (2)
  1. YktB-like [142914] (1)
    Pfam 06335; DUF1054
  2. PF0168-like [142917] (1)
Mago nashi protein [89816] (1)
beta(4)-alpha-beta(2)-alpha; 2 layers: alpha/beta; antiparallel beta-sheet, order: 651234
1. Mago nashi protein [89817] (1)
  1. Mago nashi protein [89818] (2)
WGR domain-like [142920] (1)
beta(4)-alpha-X-beta; 2 layers, a/b; antiparallel beta-sheet, order 51234; the beta-hairpin insetrion in strand 1 results in the formation of a beta-triangle structure
1. WGR domain-like [142921] (1)
  1. WGR domain [142922] (1)
    Pfam 05406; the conserved WGR motif maps to the C-end of strand 3, both large sidechains are exposed
Ribosomal protein S5 domain 2-like [54210] (1)
core: beta(3)-alpha-beta-alpha; 2 layers: alpha/beta; left-handed crossover
1. Ribosomal protein S5 domain 2-like [54211] (12)
  1. Translational machinery components [54212] (6)
  2. RNase P protein [54220] (3)
  3. DNA gyrase/MutL, second domain [54224] (7)
  4. Hsp90 middle domain [102755] (1)
    related to the DNA gyrase/MutL family; contains extra C-terminal alpha/beta subdomain
  5. Ribonuclease PH domain 1-like [54229] (4)
  6. GHMP Kinase, N-terminal domain [54232] (10)
  7. Early switch protein XOL-1, N-terminal domain [89824] (1)
    diverged from the GHMP Kinase family; lost the ATP-binding site
  8. UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase LpxC [89827] (1)
    duplication; there are two structural repeats of this fold; each repeat is elaborated with additional structures forming the active site
  9. Imidazole glycerol phosphate dehydratase [102766] (3)
    duplication; there are two structural repeats of this fold
  10. ATP-dependent protease Lon (La), catalytic domain [102769] (2)
    contains extra C-terminal alpha/beta subdomain
  11. YigZ N-terminal domain-like [102772] (2)
    modification of the common fold; contains extra alpha-beta unit after strand 2, the extra strand is inserted between strands 3 and 4
  12. Formaldehyde-activating enzyme, FAE [117795] (1)
    modification of the common fold; contains extra alpha-beta unit after strand 2, the extra strand extends beta-sheet antiparallel to strand 3
beta-Grasp (ubiquitin-like) [54235] (13)
core: beta(2)-alpha-beta(2); mixed beta-sheet 2143
1. Ubiquitin-like [54236] (7)
  1. Ubiquitin-related [54237] (47)
    Pfam 00240
  2. UBX domain [54250] (5)
    Pfam 00789
  3. GABARAP-like [54253] (5)
    intracellular membrane trafficking and fusion proteins
  4. First domain of FERM [54256] (7)
  5. Ras-binding domain, RBD [54263] (16)
    contains Pfam 00788 and Pfam 02196
  6. BM-002-like [75362] (3)
    Pfam 03671; UPF0185; this family comprises small uncharacterized proteins including human protein BM-002
  7. APG12-like [142972] (1)
    Pfam 04110
2. CAD & PB1 domains [54277] (2)
  contain extra helix; similar heterodimerization modes; possibly related to the ubiquitin-like superfamily
  1. CAD domain [54278] (5)
  2. PB1 domain [64225] (11)
    Pfam 00564
    forms heterodimers, although not all PB1 domain pairs associate.
3. MoaD/ThiS [54285] (3)
  possible link between the ubiquitin-like and 2Fe-2S ferredoxin-like superfamilies
  1. MoaD [54286] (3)
  2. ThiS [54289] (4)
  3. C9orf74 homolog [117833] (1)
4. TGS-like [81271] (2)
  possibly related to the ubiquitin-like and MoaD/ThiS superfamilies; some similarity to the alpha-L RNA-binding motif
  1. TGS domain [81270] (2)
  2. G domain-linked domain [82583] (3)
5. 2Fe-2S ferredoxin-like [54292] (2)
  1. 2Fe-2S ferredoxin-related [54293] (19)
  2. 2Fe-2S ferredoxin domains from multidomain proteins [54312] (16)
6. Staphylokinase/streptokinase [54328] (1)
  1. Staphylokinase/streptokinase [54329] (2)
7. Doublecortin (DC) [89837] (1)
  possibly related to the ubiquitin-like superfamily
  1. Doublecortin (DC) [89838] (2)
8. Superantigen toxins, C-terminal domain [54334] (1)
  1. Superantigen toxins, C-terminal domain [54335] (14)
9. Immunoglobulin-binding domains [54358] (1)
  1. Immunoglobulin-binding domains [54359] (2)
10. Translation initiation factor IF3, N-terminal domain [54364] (1)
  1. Translation initiation factor IF3, N-terminal domain [54365] (1)
11. Glutamine synthetase, N-terminal domain [54368] (1)
  1. Glutamine synthetase, N-terminal domain [54369] (2)
12. TmoB-like [110814] (1)
  possibly related to the ubiquitin-like and/or 2Fe-2S ferredoxin-like superfamilies
  1. TmoB-like [110815] (1)
    Pfam 06234
13. Nqo1 middle domain-like [142984] (1)
  possibly evolved from 2Fe-2S ferredoxins; contains no iron-sulfur cluster
  1. Nqo1 middle domain-like [142985] (1)
    C-terminal part of Pfam 01512
WWE domain [117838] (1)
beta(2)-alpha-beta(4); antiparallel folded beta-sheet (half-barrel), order 216543
1. WWE domain [117839] (1)
  1. WWE domain [117840] (1)
    Pfam 02825
FAD-linked reductases, C-terminal domain [54372] (1)
alpha+beta sandwich
1. FAD-linked reductases, C-terminal domain [54373] (7)
  N-terminal domain is beta/beta/alpha common fold
  1. GMC oxidoreductases [54374] (7)
  2. PHBH-like [54378] (3)
  3. D-aminoacid oxidase-like [54384] (4)
  4. UDP-galactopyranose mutase [69670] (2)
  5. L-aminoacid/polyamine oxidase [54394] (7)
  6. GDI-like [54399] (3)
    Similar to FAD-linked reductases in both domains but does not bind FAD
  7. Electron transfer flavoprotein-ubiquinone oxidoreductase-like [142988] (1)
Cystatin-like [54402] (7)
Core: alpha-beta(4); helix packs against coiled antiparallel beta-sheet
1. Cystatin/monellin [54403] (5)
  has a additional strand at the N-terminus
  1. Monellin [54404] (1)
  2. Cystatins [54407] (6)
  3. Cathelicidin motif [82592] (1)
    cathelin-like domain
  4. Staphopain B, prodomain [117846] (1)
  5. Latexin-like [142991] (1)
    Pfam 06907; duplication: consits of two domains of this fold
2. Amine oxidase N-terminal region [54416] (1)
  1. Amine oxidase N-terminal region [54417] (5)
    duplication: contains two domains of this fold
3. DsbC/DsbG N-terminal domain-like [54423] (1)
  1. DsbC/DsbG N-terminal domain-like [54424] (3)
4. NTF2-like [54427] (13)
  has a beta-alpha(2)-beta insertion after the main helix
  1. Scytalone dehydratase [54428] (1)
  2. NTF2-like [54431] (9)
  3. Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A [89851] (1)
  4. Limonene-1,2-epoxide hydrolase [89854] (1)
  5. Small polyketide cyclase [102810] (1)
  6. Hypothetical protein YesE [102813] (1)
  7. Ketosteroid isomerase-like [54434] (3)
  8. Ring hydroxylating beta subunit [54438] (5)
    Pfam 00866
  9. Penicillin binding protein 2a (PBP2A), N-terminal domain [82595] (1)
    some sequence similarity to KSI
  10. Orange carotenoid protein, C-terminal domain [82598] (1)
  11. Hypothetical protein egc068 from a soil-derived mobile gene cassette [110826] (1)
  12. PA1314-like [110829] (1)
    COG4460
  13. TIM44-like [143001] (1)
    contains extra N-terminal helices but lacks the beta-hairpin in the superfamily-specific insertion
5. Uracil-DNA glycosylase inhibitor protein [54441] (1)
  has an additional strand at the C-terminus and a helix inserted after the first strand
  1. Uracil-DNA glycosylase inhibitor protein [54442] (2)
6. Putative dsDNA mimic [102816] (1)
  elaborated with additional structures; some similarity to Uracil-DNA glycosylase (UGI) and Nuclease A (NuiA) inhibitors
  1. Putative dsDNA mimic [102817] (1)
    Pfam 04269, DUF440
7. Pre-PUA domain [88802] (4)
  this domain is found in association with the PUA domain in the C-terminal region of Archaeosine tRNA-guanine transglycosylase and related stand-alone proteins
  1. Archaeosine tRNA-guanine transglycosylase, C2 domain [88803] (1)
  2. Hypothetical protein Ta1423, N-terminal domain [102820] (1)
  3. Nip7p homolog, N-terminal domain [110832] (1)
  4. Hypothetical protein APE0525, N-terminal domain [143004] (1)
Nuclease A inhibitor (NuiA) [82601] (1)
alpha-beta-alpha-beta-alpha(2)-beta(3); antiparallel beta-sheet; order: 15432
1. Nuclease A inhibitor (NuiA) [82602] (1)
  some structural similarity to Uracil-DNA glycosylase inhibitor and putative dsDNA mimic HI1450 of the cystatin-like fold
  1. Nuclease A inhibitor (NuiA) [82603] (1)
Colicin D/E5 nuclease domain [102823] (1)
alpha(2)-beta(4)-alpha, 2 layers: alpha/beta, antiparallel beta sheet, meander
1. Colicin D/E5 nuclease domain [102824] (2)
  1. Colicin D nuclease domain [102825] (1)
  2. Colicin E5 nuclease domain [143007] (1)
RelE-like [143010] (1)
beta-alpha(2)-beta(4), 2 layers; a/b, antiparallel beta-sheet; order 15432
1. RelE-like [143011] (2)
  Toxin component of plasmid stabilisation system
  1. YoeB/Txe-like [143012] (1)
    Pfam 06769
  2. RelE-like [143015] (2)
    Pfam 05016
Hypothetical protein SAV1430 [110835] (1)
beta(3)-alpha-beta(2)-alpha; 2 layers, alpha/beta; antiparallel beta-sheet, order: 12543
1. Hypothetical protein SAV1430 [110836] (1)
  1. Hypothetical protein SAV1430 [110837] (1)
Ns1 effector domain-like [143020] (1)
beta-X-beta(5)-alpha-beta-alpha; 2 layers: a/b; bifurcated beta-sheet; order 23654[1,7]
1. Ns1 effector domain-like [143021] (1)
  1. Ns1 effector domain-like [143022] (1)
    C-terminal part of Pfam 00600
YbaB-like [82606] (1)
core: alpha-beta(3)-alpha, 2 layers:alpha/beta, three-stranded antiparallel beta sheet, strand order 123
1. YbaB-like [82607] (1)
  forms tight dimer of a 3-layer structure: beta/alpha/beta
  1. YbaB-like [82608] (2)
    Pfam 02575; DUF149; function unknown
Kinetochore globular domain-like [143025] (1)
core: alpha-beta(3)-alpha; variant: alpha-beta(4)-alpha(2)
1. Kinetochore globular domain [143026] (2)
  swapped heterodimer with the N-terminal helices; Spc24-like subunits have the core fold, whereas Spc25-like subunits have a variant fold
  1. Spc25-like [143027] (1)
    Pfam 08234
  2. Spc24-like [143030] (1)
    Pfam 08286
L35p-like [143033] (1)
core: alpha-beta(3)-alpha; 2layers a/b
1. L35p-like [143034] (1)
  1. Ribosomal protein L35p [143035] (1)
    Pfam 01632
Cell division protein ZapA-like [102828] (1)
core: beta(2)-alpha(2), 2 layers: alpha/beta; long C-terminal helix forms dimeric parallel and tetrameric antiparallel coiled coils
1. Cell division protein ZapA-like [102829] (1)
  1. Cell division protein ZapA-like [102830] (1)
    Pfam 05164; ZapA is a Z-ring associated protein first discovered in B. subtilis (formerly hypothetical protein YshA);
ssDNA-binding transcriptional regulator domain [54446] (1)
helix-swapped dimer of beta(4)-alpha motifs
1. ssDNA-binding transcriptional regulator domain [54447] (4)
  1. Transcriptional coactivator PC4 C-terminal domain [54448] (1)
    dimer of two separate motifs
  2. Plant transcriptional regulator PBF-2 [75375] (1)
    single-chain domain formed by a tandem repeat of two motifs
  3. PMN2A0962/syc2379c-like [143038] (2)
    Pfam 08848; DUF1818; specific to cyanobacteria; single-chain domain made of two repeats of this structural motif
  4. Guide RNA binding protein gBP [143043] (2)
    includes PfamB 080318 and PB073991; forms heterooligomers; similar subunit and oligomeric structures to the Plant transcriptional regulator family
Photosystem I subunit PsaD [64233] (1)
beta-BETA(2)-beta-alpha-beta(2); antiparallel sheet: order 2134 packed against helix and BETA-hairpin on the same side; irregular C-terminal tail
1. Photosystem I subunit PsaD [64234] (1)
  1. Photosystem I subunit PsaD [64235] (1)
MHC antigen-recognition domain [54451] (1)
dimeric
1. MHC antigen-recognition domain [54452] (1)
  1. MHC antigen-recognition domain [54453] (67)
UBC-like [54494] (1)
alpha-beta(4)-alpha(3); core: meander beta-sheet plus one helix 2
1. UBC-like [54495] (4)
  1. UBC-related [54496] (37)
  2. UEV domain [75383] (2)
  3. RWD domain [110843] (1)
    Pfam 05773
  4. UFC1-like [143072] (1)
SAND domain-like [63762] (1)
core: three short helices packed against a barrel-like beta-sheet; some similarity to the SH3-like fold
1. SAND domain-like [63763] (2)
  1. SAND domain [63764] (3)
  2. SMAD4-binding domain of oncoprotein Ski [82611] (1)
Coronavirus NSP8-like [143075] (1)
core: alpha-beta(2)-alpha-beta(4)-alpha-beta; bifurcated barrel-like beta-sheet
1. Coronavirus NSP8-like [143076] (1)
  1. Coronavirus NSP8-like [143077] (1)
ParB/Sulfiredoxin [110848] (1)
beta*-alpha-beta(2)-alpha-beta-alpha; mixed beta sheet forms a partly open barrel: (n*=4, S*=8)
1. ParB/Sulfiredoxin [110849] (2)
  1. ParB-like nuclease domain [110850] (1)
    Pfam 02195
  2. Hypothetical protein PF0380 [110853] (1)
    contains insert domain (101-200) of an unusual alpha+beta fold beta-alpha-beta-alpha-beta(2)-alpha-beta-alpha-beta; 3 layers: a/b/a; antiparallel beta-sheet, order 516342; possibly related to Pfam 06245
BtrG-like [110856] (1)
beta-alpha-beta(4)-alpha-beta(2); contains beta-sheet barrel (n=5, S=8)
1. BtrG-like [110857] (1)
  1. BtrG-like [110858] (3)
    Pfam 03674
BB1717-like [143080] (1)
complex fold with a bifurcated beta-sheet structure surrounded by helices; contains beta-sheet barrel, closed (n=5, S=8)
1. BB1717-like [143081] (1)
  1. BB1717-like [143082] (4)
    Pfam 02586; DUF159, COG2135
AF0104/ALDC/Ptd012-like [117855] (1)
duplication: consists of two similar beta-alpha-beta(4) motifs
1. AF0104/ALDC/Ptd012-like [117856] (3)
  characteristic metal ion (zinc)-binding motif in the putative active site
  1. Alpha-acetolactate decarboxylase-like [117857] (1)
    Pfam 03306
  2. PTD012-like [143091] (1)
  3. AF0104-like [143094] (2)
    Pfam 03479; DUF296; PD1 domain; plant- and prokaryote conserved (PPC; see new PDB 2DT4)
NSFL1 (p97 ATPase) cofactor p47, SEP domain [102847] (1)
beta(3)-alpha(2)-beta; 2 layers; mixed beta-sheet, order 4123, strands 1 and 4 are parallel to each other
1. NSFL1 (p97 ATPase) cofactor p47, SEP domain [102848] (1)
  1. NSFL1 (p97 ATPase) cofactor p47, SEP domain [102849] (2)
TTHA1013-like [143099] (1)
beta(3)-alpha-beta; 2 layers; mixed beta-sheet, order 4123, strands 1 and 4 are parallel to each other; topological similarity to the SEP domain fold (scop_cf 102847); dimerises via the long C-terminal strand with the formation of a single beta-sheet
1. TTHA1013-like [143100] (1)
  1. TTHA1013-like [143101] (1)
Diaminopimelate epimerase-like [54505] (1)
mixed beta-sheet folds into a barrel (n=8, S=14) around the central helix
1. Diaminopimelate epimerase-like [54506] (3)
  duplication: consists of two similar domain swapped with C-terminal strands
  1. Diaminopimelate epimerase [54507] (1)
  2. PhzC/PhzF-like [89863] (4)
    Pfam 02567
  3. Proline racemase [110863] (1)
    Pfam 05544
GFP-like [54510] (1)
beta-sheet folds into a barrel (n=11, S=14) around the central helix
1. GFP-like [54511] (2)
  1. Fluorescent proteins [54512] (5)
  2. Domain G2 of nidogen-1 [64244] (1)
Tubby C-terminal domain-like [54517] (1)
beta-sheet folds into a barrel (n=12, S=12) around the central helix
1. Tubby C-terminal domain-like [54518] (2)
  1. Transcriptional factor tubby, C-terminal domain [54519] (1)
  2. At5g01750-like [143104] (1)
    Pfam 04525; DUF567
Pili subunits [54522] (1)
contains very long N-terminal helix, which end is packed against beta-sheet
1. Pili subunits [54523] (4)
  bacterial filament proteins
  1. Pilin [54524] (4)
  2. TcpA-like pilin [89868] (1)
    common fold is decorated with additional structures
  3. Pseudopilin [117865] (1)
  4. YadA C-terminal domain-like [143107] (1)
    Pfam 03895; trimerizes with the formation of closed beta-barrel (n=12, S=12), wrapped around triple parallel coiled coil
Mitochondrial glycoprotein MAM33-like [54528] (1)
core: beta(