Structural Classification of Proteins
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Class: Alpha and beta proteins (a+b)

Mainly antiparallel beta sheets (segregated alpha and beta regions)

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a+b) [53931]
    Mainly antiparallel beta sheets (segregated alpha and beta regions)

Folds:

  1. Microbial ribonucleases [53932] (1)
    single helix packs against antiparallel beta-sheet
    1. Microbial ribonucleases [53933] (3) picpic
  2. Lysozyme-like [53954] (1)
    common alpha+beta motif for the active site region
    1. Lysozyme-like [53955] (7) picpic
  3. Cysteine proteinases [54000] (1)
    consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn
    1. Cysteine proteinases [54001] (16) picpic
      the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet
  4. His-Me finger endonucleases [54059] (1)
    core: (alpha)-beta-omega_loop-beta-alpha; embeded in larger different structures
    1. His-Me finger endonucleases [54060] (6) picpic
      common motif contains conserved histidine residue and metal-binding site
  5. RNase A-like [54075] (1)
    contains long curved beta-sheet and 3 helices
    1. RNase A-like [54076] (1) picpic
      can be classified as disulfide-rich
  6. EndoU-like [142876] (1)
    comprises several helices and two three-stranded antiparallel beta-sheets; similar architecture to the RNase A-like fold (scop_cf 54075)
    1. EndoU-like [142877] (2) picpic
      similarity to the RNase A-like superfamily (scop_sf 54076) extends to the active site location and architecture; the two structural cores of the RNase A and EndoU superfamilies are interrelated by a topological permutation - transposition of two pereferial beta-strands, suggesting possible distant homology of the two superfamilies (and their unification in a hyperfamily)
  7. Prion-like [54097] (1)
    beta-alpha-beta-alpha(2); antiparallel beta-ribbon
    1. Prion-like [54098] (1) picpic
  8. LysM domain [54105] (1)
    beta-alpha(2)-beta; antiparallel strands
    1. LysM domain [54106] (1) picpic
  9. Head-to-tail joining protein W, gpW [64209] (1)
    alpha-beta(2)-alpha; antiparallel hairpin
    1. Head-to-tail joining protein W, gpW [64210] (1) picpic
  10. Hypothetical protein MTH677 [110782] (1)
    alpha-beta(2)-alpha; 2 layers a/b; antiparallel beta-hairpin
    1. Hypothetical protein MTH677 [110783] (1) picpic
  11. GTF2I-like repeat [117772] (1)
    alpha(2)-beta-alpha-beta-alpha; 2 layers: a/b; antiparallel beta-ribbon
    1. GTF2I-like repeat [117773] (1) picpic
  12. Urease, gamma-subunit [54110] (1)
    alpha(3)-beta(2); antiparallel hairpin
    1. Urease, gamma-subunit [54111] (1) picpic
  13. IL8-like [54116] (2)
    beta(3)-alpha
    1. Interleukin 8-like chemokines [54117] (1) picpic
      form dimers with different dimerisation modes
    2. PhtA domain-like [142887] (1) picpic
      contains extra N-terminal beta-hairpin, like structurally similar archaeal "histone-like" proteins (scop_fa 54161), but does not adopt its SH3-like barrel fold
  14. DNA-binding domain [54170] (1)
    beta(3)-alpha; 2 layers: alpha/beta
    1. DNA-binding domain [54171] (4) picpic
  15. Penicillin-binding protein 2x (pbp-2x), c-terminal domain [54183] (1)
    alpha1-beta3; 2 layers: alpha/beta; order 132
    1. Penicillin-binding protein 2x (pbp-2x), c-terminal domain [54184] (1) picpic
      duplication: consists of 2 subdomains of this fold
  16. Dodecin subunit-like [88797] (5)
    beta-alpha-beta(2); 2 layers: alpha/beta; antiparallel beta-sheet: order 132
    1. Flavin-binding protein dodecin [89807] (1) picpic
    2. Amyloid beta a4 protein copper binding domain (domain 2) [89811] (1) picpic
    3. N-terminal, heterodimerisation domain of RBP7 (RpoE) [88798] (1) picpic
    4. D-lysine 5,6-aminomutase beta subunit KamE, N-terminal domain [117778] (1) picpic
    5. YbjQ-like [117782] (1) picpic
      pentamer, beta/alpha-propeller; additional short beta-strands promote oligomeric assembly
  17. Ribosomal proteins S24e, L23 and L15e [54188] (1)
    beta-(alpha)-beta-alpha-beta(2); 3 layers: alpha/beta/alpha; antiparallel beta-sheet: order 1243
    1. Ribosomal proteins S24e, L23 and L15e [54189] (3) picpic
  18. Ribosome binding domain-like [100965] (2)
    beta-(2)-alpha(2)-beta(2); 2 layers: beta/alpha; antiparallel beta-sheet: order 1243; topological similarity to the common core of ribosomal proteins L23 and L15e
    1. Trigger factor ribosome-binding domain [102735] (1) picpic
    2. Translation initiation factor 2 beta, aIF2beta, N-terminal domain [100966] (1) picpic
  19. TFB5-like [142896] (1)
    beta-alpha-beta(2)-alpha; 2 layers, a/b; antiparallel sheet, order: 132; dimerises in solution (PDB 2jnj) via extended N-terminal strand
    1. TFB5-like [142897] (1) picpic
  20. Obg GTP-binding protein C-terminal domain [102740] (1)
    beta-(2)-alpha(3)-beta(2); 2 layers: beta/alpha; mixed beta-sheet: order 1234; strands 2 and 3 a parallel to each other
    1. Obg GTP-binding protein C-terminal domain [102741] (1) picpic
  21. HIT-like [54196] (2)
    alpha-beta(3)-alpha-beta(2); 3 layers: alpha/beta/alpha
    1. HIT-like [54197] (3) picpic
    2. Rotavirus NSP2 fragment, C-terminal domain [75347] (1) picpic
  22. Secretion chaperone-like [69634] (3)
    alpha-beta(3)-alpha-beta(2)-alpha; 2 layers: alpha/beta
    1. Type III secretory system chaperone [69635] (1) picpic
    2. Arp2/3 complex subunits [69645] (1) picpic
    3. YjbR-like [142906] (1) picpic
      overall similar to the Type III secretory system chaperone subunits; different shape of the beta-sheet
  23. DNA-binding domain of intron-encoded endonucleases [64495] (1)
    beta(2)-alpha(2)-beta; 2 layers; 3-stranded antiparallel beta-sheet, order 213; HTH motif; also includes the extra N-terminal, DNA minor groove-binding helix
    1. DNA-binding domain of intron-encoded endonucleases [64496] (1) picpic
  24. MotA C-terminal domain-like [69651] (1)
    alpha-beta(4)-alpha-beta(2)-alpha; 2 layers: alpha/beta
    1. DNA-binding C-terminal domain of the transcription factor MotA [69652] (1) picpic
  25. YktB/PF0168-like [142912] (1)
    alpha-beta(4)-alpha-beta(2)-alpha-beta-alpha; 2 layers, a/b; antiparallel beta-sheet, order: 1234756; half-barrel shape; topological similarity to the MotA C-terminal domain-like fold (scop_cf 69651) and the Secretion chaperone-like fold (scop_cf 69634)
    1. YktB/PF0168-like [142913] (2) picpic
  26. Mago nashi protein [89816] (1)
    beta(4)-alpha-beta(2)-alpha; 2 layers: alpha/beta; antiparallel beta-sheet, order: 651234
    1. Mago nashi protein [89817] (1) picpic
  27. WGR domain-like [142920] (1)
    beta(4)-alpha-X-beta; 2 layers, a/b; antiparallel beta-sheet, order 51234; the beta-hairpin insetrion in strand 1 results in the formation of a beta-triangle structure
    1. WGR domain-like [142921] (1) picpic
  28. Ribosomal protein S5 domain 2-like [54210] (1)
    core: beta(3)-alpha-beta-alpha; 2 layers: alpha/beta; left-handed crossover
    1. Ribosomal protein S5 domain 2-like [54211] (12) picpic
  29. beta-Grasp (ubiquitin-like) [54235] (13)
    core: beta(2)-alpha-beta(2); mixed beta-sheet 2143
    1. Ubiquitin-like [54236] (7) picpic
    2. CAD & PB1 domains [54277] (2) picpic
      contain extra helix; similar heterodimerization modes; possibly related to the ubiquitin-like superfamily
    3. MoaD/ThiS [54285] (3) picpic
      possible link between the ubiquitin-like and 2Fe-2S ferredoxin-like superfamilies
    4. TGS-like [81271] (2) picpic
      possibly related to the ubiquitin-like and MoaD/ThiS superfamilies; some similarity to the alpha-L RNA-binding motif
    5. 2Fe-2S ferredoxin-like [54292] (2) picpic
    6. Staphylokinase/streptokinase [54328] (1) picpic
    7. Doublecortin (DC) [89837] (1) picpic
      possibly related to the ubiquitin-like superfamily
    8. Superantigen toxins, C-terminal domain [54334] (1) picpic
    9. Immunoglobulin-binding domains [54358] (1) picpic
    10. Translation initiation factor IF3, N-terminal domain [54364] (1) picpic
    11. Glutamine synthetase, N-terminal domain [54368] (1) picpic
    12. TmoB-like [110814] (1) picpic
      possibly related to the ubiquitin-like and/or 2Fe-2S ferredoxin-like superfamilies
    13. Nqo1 middle domain-like [142984] (1) picpic
      possibly evolved from 2Fe-2S ferredoxins; contains no iron-sulfur cluster
  30. WWE domain [117838] (1)
    beta(2)-alpha-beta(4); antiparallel folded beta-sheet (half-barrel), order 216543
    1. WWE domain [117839] (1) picpic
  31. FAD-linked reductases, C-terminal domain [54372] (1)
    alpha+beta sandwich
    1. FAD-linked reductases, C-terminal domain [54373] (7) picpic
      N-terminal domain is beta/beta/alpha common fold
  32. Cystatin-like [54402] (7)
    Core: alpha-beta(4); helix packs against coiled antiparallel beta-sheet
    1. Cystatin/monellin [54403] (5) picpic
      has a additional strand at the N-terminus
    2. Amine oxidase N-terminal region [54416] (1) picpic
    3. DsbC/DsbG N-terminal domain-like [54423] (1) picpic
    4. NTF2-like [54427] (13) picpic
      has a beta-alpha(2)-beta insertion after the main helix
    5. Uracil-DNA glycosylase inhibitor protein [54441] (1) picpic
      has an additional strand at the C-terminus and a helix inserted after the first strand
    6. Putative dsDNA mimic [102816] (1) picpic
      elaborated with additional structures; some similarity to Uracil-DNA glycosylase (UGI) and Nuclease A (NuiA) inhibitors
    7. Pre-PUA domain [88802] (4) picpic
      this domain is found in association with the PUA domain in the C-terminal region of Archaeosine tRNA-guanine transglycosylase and related stand-alone proteins
  33. Nuclease A inhibitor (NuiA) [82601] (1)
    alpha-beta-alpha-beta-alpha(2)-beta(3); antiparallel beta-sheet; order: 15432
    1. Nuclease A inhibitor (NuiA) [82602] (1) picpic
      some structural similarity to Uracil-DNA glycosylase inhibitor and putative dsDNA mimic HI1450 of the cystatin-like fold
  34. Colicin D/E5 nuclease domain [102823] (1)
    alpha(2)-beta(4)-alpha, 2 layers: alpha/beta, antiparallel beta sheet, meander
    1. Colicin D/E5 nuclease domain [102824] (2) picpic
  35. RelE-like [143010] (1)
    beta-alpha(2)-beta(4), 2 layers; a/b, antiparallel beta-sheet; order 15432
    1. RelE-like [143011] (2) picpic
      Toxin component of plasmid stabilisation system
  36. Hypothetical protein SAV1430 [110835] (1)
    beta(3)-alpha-beta(2)-alpha; 2 layers, alpha/beta; antiparallel beta-sheet, order: 12543
    1. Hypothetical protein SAV1430 [110836] (1) picpic
  37. Ns1 effector domain-like [143020] (1)
    beta-X-beta(5)-alpha-beta-alpha; 2 layers: a/b; bifurcated beta-sheet; order 23654[1,7]
    1. Ns1 effector domain-like [143021] (1) picpic
  38. YbaB-like [82606] (1)
    core: alpha-beta(3)-alpha, 2 layers:alpha/beta, three-stranded antiparallel beta sheet, strand order 123
    1. YbaB-like [82607] (1) picpic
      forms tight dimer of a 3-layer structure: beta/alpha/beta
  39. Kinetochore globular domain-like [143025] (1)
    core: alpha-beta(3)-alpha; variant: alpha-beta(4)-alpha(2)
    1. Kinetochore globular domain [143026] (2) picpic
      swapped heterodimer with the N-terminal helices; Spc24-like subunits have the core fold, whereas Spc25-like subunits have a variant fold
  40. L35p-like [143033] (1)
    core: alpha-beta(3)-alpha; 2layers a/b
    1. L35p-like [143034] (1) picpic
  41. Cell division protein ZapA-like [102828] (1)
    core: beta(2)-alpha(2), 2 layers: alpha/beta; long C-terminal helix forms dimeric parallel and tetrameric antiparallel coiled coils
    1. Cell division protein ZapA-like [102829] (1) picpic
  42. ssDNA-binding transcriptional regulator domain [54446] (1)
    helix-swapped dimer of beta(4)-alpha motifs
    1. ssDNA-binding transcriptional regulator domain [54447] (4) picpic
  43. Photosystem I subunit PsaD [64233] (1)
    beta-BETA(2)-beta-alpha-beta(2); antiparallel sheet: order 2134 packed against helix and BETA-hairpin on the same side; irregular C-terminal tail
    1. Photosystem I subunit PsaD [64234] (1) picpic
  44. MHC antigen-recognition domain [54451] (1)
    dimeric
    1. MHC antigen-recognition domain [54452] (1) picpic
  45. UBC-like [54494] (1)
    alpha-beta(4)-alpha(3); core: meander beta-sheet plus one helix 2
    1. UBC-like [54495] (4) picpic
  46. SAND domain-like [63762] (1)
    core: three short helices packed against a barrel-like beta-sheet; some similarity to the SH3-like fold
    1. SAND domain-like [63763] (2) picpic
  47. Coronavirus NSP8-like [143075] (1)
    core: alpha-beta(2)-alpha-beta(4)-alpha-beta; bifurcated barrel-like beta-sheet
    1. Coronavirus NSP8-like [143076] (1) picpic
  48. ParB/Sulfiredoxin [110848] (1)
    beta*-alpha-beta(2)-alpha-beta-alpha; mixed beta sheet forms a partly open barrel: (n*=4, S*=8)
    1. ParB/Sulfiredoxin [110849] (2) picpic
  49. BtrG-like [110856] (1)
    beta-alpha-beta(4)-alpha-beta(2); contains beta-sheet barrel (n=5, S=8)
    1. BtrG-like [110857] (1) picpic
  50. BB1717-like [143080] (1)
    complex fold with a bifurcated beta-sheet structure surrounded by helices; contains beta-sheet barrel, closed (n=5, S=8)
    1. BB1717-like [143081] (1) picpic
  51. AF0104/ALDC/Ptd012-like [117855] (1)
    duplication: consists of two similar beta-alpha-beta(4) motifs
    1. AF0104/ALDC/Ptd012-like [117856] (3) picpic
      characteristic metal ion (zinc)-binding motif in the putative active site
  52. NSFL1 (p97 ATPase) cofactor p47, SEP domain [102847] (1)
    beta(3)-alpha(2)-beta; 2 layers; mixed beta-sheet, order 4123, strands 1 and 4 are parallel to each other
    1. NSFL1 (p97 ATPase) cofactor p47, SEP domain [102848] (1) picpic
  53. TTHA1013-like [143099] (1)
    beta(3)-alpha-beta; 2 layers; mixed beta-sheet, order 4123, strands 1 and 4 are parallel to each other; topological similarity to the SEP domain fold (scop_cf 102847); dimerises via the long C-terminal strand with the formation of a single beta-sheet
    1. TTHA1013-like [143100] (1) picpic
  54. Diaminopimelate epimerase-like [54505] (1)
    mixed beta-sheet folds into a barrel (n=8, S=14) around the central helix
    1. Diaminopimelate epimerase-like [54506] (3) picpic
      duplication: consists of two similar domain swapped with C-terminal strands
  55. GFP-like [54510] (1)
    beta-sheet folds into a barrel (n=11, S=14) around the central helix
    1. GFP-like [54511] (2) picpic
  56. Tubby C-terminal domain-like [54517] (1)
    beta-sheet folds into a barrel (n=12, S=12) around the central helix
    1. Tubby C-terminal domain-like [54518] (2) picpic
  57. Pili subunits [54522] (1)
    contains very long N-terminal helix, which end is packed against beta-sheet
    1. Pili subunits [54523] (4) picpic
      bacterial filament proteins
  58. Mitochondrial glycoprotein MAM33-like [54528] (1)
    core: beta(7)-alpha(2); N- and C-terminal extensions form a coiled coil subdomain
    1. Mitochondrial glycoprotein MAM33-like [54529] (1) picpic
  59. NAP-like [143112] (1)
    core: central meander 4-stranded beta-sheet (order: 1234) transversed by a C-terminal helix
    1. NAP-like [143113] (1) picpic
  60. Polo-box domain [82614] (1)
    beta(6)-alpha; antiparallel beta-sheet, meander
    1. Polo-box domain [82615] (2) picpic
      Serine/threonine protein kinase-associated motif embedded in two distinct folds
  61. mRNA decapping enzyme DcpS N-terminal domain [102859] (1)
    beta(3)-alpha-beta(3)-alpha; 3 layers a/b/a
    1. mRNA decapping enzyme DcpS N-terminal domain [102860] (1) picpic
      forms swapped dimer with two 6-stranded antiparallel beta sheets; order 1236[5][4]
  62. Inhibitor of vertebrate lysozyme, Ivy [89871] (1)
    alpha(2)-beta(5)-alpha(2); 3 layers a/b/a; meander beta-sheet
    1. Inhibitor of vertebrate lysozyme, Ivy [89872] (1) picpic
  63. FKBP-like [54533] (3)
    core: beta(2)-alpha-beta(2); antiparallel beta-sheet
    1. FKBP-like [54534] (3) picpic
    2. Colicin E3 immunity protein [54552] (1) picpic
    3. Chitinase insertion domain [54556] (1) picpic
  64. Ribosomal protein S16 [54564] (1)
    beta(4)-alpha-beta; 2 layers: alpha/beta; mixed beta-sheet, order: 51234
    1. Ribosomal protein S16 [54565] (1) picpic
  65. Ribosomal protein S19 [54569] (1)
    alpha-beta-X-beta(2); 2 layers: alpha/beta; mixed beta-sheet, order: 123
    1. Ribosomal protein S19 [54570] (1) picpic
  66. YefM-like [143119] (1)
    core: beta-alpha(2)-beta(2)-alpha; mixed beta-sheet, order:123, strands 1 and 2 are parallel; forms compact dimer with a single beta-sheet;
    1. YefM-like [143120] (1) picpic
  67. Ribosomal protein L31e [54574] (1)
    beta-alpha-beta-(alpha)-beta(2); 2 layers: alpha/beta; mixed beta-sheet, order: 1342
    1. Ribosomal protein L31e [54575] (1) picpic
  68. Allophycocyanin linker chain (domain) [54579] (1)
    beta(2)-alpha-beta; 2 layers: alpha/beta
    1. Allophycocyanin linker chain (domain) [54580] (1) picpic
  69. Cdc48 domain 2-like [54584] (1)
    beta-alpha-beta(3); 2 layers: alpha/beta
    1. Cdc48 domain 2-like [54585] (1) picpic
  70. Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [54592] (1)
    beta-alpha-beta(3); 2 layers: alpha/beta
    1. Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [54593] (10) picpic
  71. Chromosomal protein MC1 [102874] (1)
    beta(2)-alpha-beta(3); 2 layers: alpha/beta
    1. Chromosomal protein MC1 [102875] (1) picpic
  72. beta-hairpin-alpha-hairpin repeat [74651] (2)
    multiple repeats of beta(2)-alpha(2) motif
    1. Ankyrin repeat [48403] (1) picpic
      repeats organized in elongated structures
    2. Plakin repeat [75399] (1) picpic
      repeats associate forming globular subdomains
  73. Proguanylin [89889] (1)
    beta(2)-alpha(3)-beta; two layers: alpha/beta; antiparallel sheet: order 213
    1. Proguanylin [89890] (1) picpic
  74. Bacterial protein-export protein SecB [54610] (1)
    beta(4)-alpha(2); two layers: alpha/beta; antiparallel sheet: order 1432
    1. Bacterial protein-export protein SecB [54611] (1) picpic
  75. MesJ substrate recognition domain-like [82828] (1)
    beta-alpha(2)-beta(3); 2 layers: a/b; antiparallel beta-sheet, order:1432
    1. MesJ substrate recognition domain-like [82829] (1) picpic
  76. FYSH domain [89894] (1)
    beta(2)-alpha(2)-beta(2)-alpha-beta; two layers: alpha/beta; antiparallel sheet: order 51234
    1. FYSH domain [89895] (2) picpic
  77. VSV matrix protein [75403] (1)
    beta-alpha(2)-beta(4)-alpha-beta(2); two layers: alpha/beta; bifurcated coiled beta-sheet: order of the first 5 strands: 23154
    1. VSV matrix protein [75404] (1) picpic
  78. DNA-binding domain of Mlu1-box binding protein MBP1 [54615] (1)
    beta(4)-alpha(2)-beta(2)-alpha; antiparallel sheet: order 123465
    1. DNA-binding domain of Mlu1-box binding protein MBP1 [54616] (1) picpic
      has some topological similarity to the "winged helix" DNA-binding domain, to B1 and B5 domains of PheRS-beta (1PYS CH B) and to methyl-CpG-binding domain
  79. Heme-binding protein A (HasA) [54620] (1)
    beta-alpha-beta(6)-alpha(2); antiparallel sheet: order 165432
    1. Heme-binding protein A (HasA) [54621] (1) picpic
  80. Chalcone isomerase [54625] (1)
    beta(3)-alpha(2)-beta-alpha(2)-beta3; 2 layers alpha/beta; antiparallel sheet: order 1234567
    1. Chalcone isomerase [54626] (1) picpic
  81. Coproporphyrinogen III oxidase [102885] (1)
    alpha-beta(6)-alpha(2)-beta-alpha(n); 3 layers alpha/beta/alpha; antiparallel sheet: order 1234567
    1. Coproporphyrinogen III oxidase [102886] (1) picpic
  82. Hypothetical protein Ta1206 [102890] (1)
    beta(4)-alpha-beta(2)-alpha(2); mixed, predominately antiparallel beta-sheet, order: 123465, strands 4 and 5 are parallel to each other
    1. Hypothetical protein Ta1206 [102891] (1) picpic
      can be divided into an N-terminal, tetramerisation all-beta subdomain and a C-terminal alpha+beta subdomain related by a circular permutation to the Y-family DNA-polymerase 'fingers' subdomain
  83. CBS-domain [54630] (1)
    core: beta-alpha-beta(4); 2 layers: alpha/beta
    1. CBS-domain [54631] (1) picpic
  84. Thioesterase/thiol ester dehydrase-isomerase [54636] (1)
    core: beta-alpha-beta(4); 2 layers: alpha/beta
    1. Thioesterase/thiol ester dehydrase-isomerase [54637] (8) picpic
  85. DLC [54647] (1)
    core: beta-alpha(2)-beta-X-beta(2); 2 layers: alpha/beta; antiparallel beta-sheet: order 1342
    1. DLC [54648] (1) picpic
  86. CI-2 family of serine protease inhibitors [54653] (1)
    alpha+beta sandwich; loop across free side of beta-sheet
    1. CI-2 family of serine protease inhibitors [54654] (1) picpic
  87. Integrin beta tail domain [69686] (1)
    alpha-beta-loop-beta(3); loop across free side of beta-sheet
    1. Integrin beta tail domain [69687] (1) picpic
  88. alpha/beta-Hammerhead [54664] (5)
    core: beta-BETA-alpha-beta-BETA-beta-alpha; contains a beta-hammerhead motif similar to that in barrel-sandwich hybrids
    1. CO dehydrogenase molybdoprotein N-domain-like [54665] (1) picpic
    2. Nicotinate/Quinolinate PRTase N-terminal domain-like [54675] (2) picpic
    3. Pyrimidine nucleoside phosphorylase C-terminal domain [54680] (1) picpic
    4. Ribosomal protein L16p/L10e [54686] (2) picpic
    5. Molybdopterin synthase subunit MoaE [54690] (1) picpic
  89. POZ domain [54694] (1)
    core: beta(2)-alpha(2)-beta(2)-alpha(2); 2 layers a/b; mixed sheet: 2143
    1. POZ domain [54695] (2) picpic
  90. EF-Ts domain-like [54712] (2)
    beta(2)-alpha(n)-beta; 2 layers a/b; antiparallel sheet: 123
    1. Elongation factor Ts (EF-Ts), dimerisation domain [54713] (1) picpic
      comprises two structural repeats of this fold
    2. Band 7/SPFH domain [117892] (1) picpic
      beta(2)-alpha(3)-beta
  91. Fe,Mn superoxide dismutase (SOD), C-terminal domain [54718] (1)
    alpha-beta(2)-alpha-beta-alpha(2); 3 strands of antiparallel sheet: 213
    1. Fe,Mn superoxide dismutase (SOD), C-terminal domain [54719] (1) picpic
  92. ClpS-like [54735] (1)
    beta-alpha(2)-beta-alpha-beta; 2 layers, alpha/beta
    1. ClpS-like [54736] (2) picpic
  93. Hypothetical protein MTH1880 [75411] (1)
    beta-alpha-beta(2)-alpha(2); 3 layers, alpha/beta/alpha; antiparallel beta-sheet: order 123
    1. Hypothetical protein MTH1880 [75412] (1) picpic
  94. Ribosomal L11/L12e N-terminal domain [54746] (1)
    beta-alpha(2)-beta(2); 2 layers, alpha/beta; antiparallel beta-sheet: order 123
    1. Ribosomal L11/L12e N-terminal domain [54747] (1) picpic
  95. Anti-LPS factor/recA domain [54751] (2)
    alpha-beta(3)-alpha(2); 2 layers, alpha/beta
    1. RecA protein, C-terminal domain [54752] (1) picpic
    2. Anti-lipopolysaccharide factor [54757] (1) picpic
  96. Signal recognition particle alu RNA binding heterodimer, SRP9/14 [54761] (1)
    (beta)-alpha-beta(3)-alpha; 2 layers, alpha/beta
    1. Signal recognition particle alu RNA binding heterodimer, SRP9/14 [54762] (1) picpic
  97. dsRBD-like [54767] (5)
    alpha-beta(3)-alpha; 2 layers: alpha/beta
    1. dsRNA-binding domain-like [54768] (3) picpic
    2. Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain [54782] (1) picpic
    3. YcfA/nrd intein domain [54786] (2) picpic
    4. Peptidyl-tRNA hydrolase domain-like [110916] (1) picpic
    5. Rv2632c-like [143212] (1) picpic
      lacks the N-terminal helix; dimerises via the N-terminal strand and the C-terminal helix with the formation of a single beta-sheet wrapped around an antiparallel coiled coil
  98. 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain [110920] (1)
    duplication: consists of two beta(3)-alpha repeats; 3 layers, beta/alpha/beta
    1. 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain [110921] (1) picpic
  99. SRP19 [69694] (1)
    beta-alpha-beta(2)-alpha; 2 layers: alpha/beta
    1. SRP19 [69695] (1) picpic
  100. SufE/NifU [82648] (1)
    alpha(2)-beta(3)-alpha(3); 2 layers alpha/beta, 3-stranded antiparallel beta-sheet; order 123
    1. SufE/NifU [82649] (3) picpic
      iron-sulfur cluster assembly proteins
  101. DNA-binding protein Tfx [89914] (1)
    alpha(3)-beta-alpha(2)-beta(2); 2 layers alpha/beta, 3-stranded antiparallel beta-sheet; order 123
    1. DNA-binding protein Tfx [89915] (1) picpic
  102. Eukaryotic type KH-domain (KH-domain type I) [54790] (1)
    beta-alpha(2)-beta(2)-alpha; 2 layers: alpha/beta
    1. Eukaryotic type KH-domain (KH-domain type I) [54791] (1) picpic
      Prokaryotic and eukaryotic domains share a KH-motif but have different topologies
  103. Alpha-lytic protease prodomain-like [54805] (8)
    core: alpha-beta(2)-(alpha)-beta; 2 layers: alpha/beta
    1. Alpha-lytic protease prodomain [54806] (1) picpic
    2. GMP synthetase C-terminal dimerisation domain [54810] (1) picpic
    3. Prokaryotic type KH domain (KH-domain type II) [54814] (1) picpic
      Prokaryotic and eukaryotic domains share a KH-motif but have different topologies
    4. Probable GTPase Der, C-terminal domain [82653] (1) picpic
      possible distant relative of the Era C-terminal domain lacking the KH motif
    5. Ribosome-binding factor A, RbfA [89919] (1) picpic
      possible distant homologue of the type I KH domain lacking the KH motif
    6. YhbC-like, N-terminal domain [75420] (1) picpic
    7. BolA-like [82657] (1) picpic
    8. Fe-S cluster assembly (FSCA) domain-like [117916] (2) picpic
      similar putative active site with a conserved cysteine residue
  104. Nucleotidyltransferase [81302] (1)
    core: alpha-beta-turn-beta-X-beta-(alpha); mixed beta-sheet, order of core strands: 123
    1. Nucleotidyltransferase [81301] (11) picpic
  105. Nqo5-like [143242] (1)
    core: alpha-beta(2)-alpha-beta(3); 2 layers, a/b; mixed beta-sheet, order 12534, strands 2 and 5 are parallel
    1. Nqo5-like [143243] (1) picpic
  106. Ribosomal protein S3 C-terminal domain [54820] (1)
    alpha(2)-beta(4); 2 layers: alpha/beta; antiparallel beta-sheet: order 2143
    1. Ribosomal protein S3 C-terminal domain [54821] (1) picpic
  107. Transcription factor NusA, N-terminal domain [69704] (1)
    alpha-beta(3)-alpha-beta-alpha; bifurcated coiled beta-sheet
    1. Transcription factor NusA, N-terminal domain [69705] (1) picpic
  108. Enolase N-terminal domain-like [54825] (1)
    beta(3)-alpha(3); meander and up-and-down bundle
    1. Enolase N-terminal domain-like [54826] (1) picpic
  109. Ribosomal protein L22 [54842] (1)
    beta-alpha(3)-beta(2); 2 layers: alpha/beta; related to the enolase/MLE N-domain fold by a circular permutation
    1. Ribosomal protein L22 [54843] (1) picpic
      some topological similarity to prokaryotic ribosomal protein L17
  110. Prokaryotic ribosomal protein L17 [64262] (1)
    alpha-beta-alpha(3)-beta(2); 2 layers: alpha/beta;
    1. Prokaryotic ribosomal protein L17 [64263] (1) picpic
      some topological similarity to ribosomal protein L22
  111. GroEL-intermediate domain like [54848] (1)
    3-helical bundle packed against 3-stranded mixed beta-sheet
    1. GroEL-intermediate domain like [54849] (2) picpic
  112. PX domain [64267] (1)
    beta(3)-alpha(4); meander beta-sheet packed against array of helices; contains Pro-rich stretch
    1. PX domain [64268] (1) picpic
  113. DsrC, the gamma subunit of dissimilatory sulfite reductase [69720] (1)
    beta(3)-alpha(5); meander beta-sheet packed against array of helices
    1. DsrC, the gamma subunit of dissimilatory sulfite reductase [69721] (1) picpic
  114. DNA damage-inducible protein DinI [54856] (1)
    beta-alpha-beta(2)-alpha; 2 layers: alpha/beta; mixed sheet 213; crossing loops
    1. DNA damage-inducible protein DinI [54857] (1) picpic
  115. HSP90 C-terminal domain [110941] (1)
    alpha-beta(3)-alpha(3); 2 layers, a/b; mixed beta-sheet, order:132; crossing loops
    1. HSP90 C-terminal domain [110942] (1) picpic
  116. Ferredoxin-like [54861] (55)
    alpha+beta sandwich with antiparallel beta-sheet; (beta-alpha-beta)x2
    1. 4Fe-4S ferredoxins [54862] (6) picpic
    2. Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain [54893] (1) picpic
    3. Protease propeptides/inhibitors [54897] (3) picpic
    4. Dimeric alpha+beta barrel [54909] (17) picpic
      dimerizes through the beta-sheet; forms beta-sheet barrel, closed (n=8, S=12); dimers may assemble in higher oligomers
    5. GlnB-like [54913] (4) picpic
      form timeric structures with the orthogonally packed beta-sheets
    6. SEA domain [82671] (1) picpic
    7. Nucleoside diphosphate kinase, NDK [54919] (1) picpic
    8. RNA-binding domain, RBD [54928] (4) picpic
    9. Viral DNA-binding domain [54957] (1) picpic
    10. RuBisCO, large subunit, small (N-terminal) domain [54966] (1) picpic
      C-terminal domain is beta/alpha barrel
    11. Acylphosphatase/BLUF domain-like [54975] (2) picpic
    12. EF-G C-terminal domain-like [54980] (3) picpic
    13. eEF-1beta-like [54984] (1) picpic
    14. eEF1-gamma domain [89942] (1) picpic
      elaborated with additional structures
    15. Anticodon-binding domain of PheRS [54991] (1) picpic
    16. Ribosomal protein S6 [54995] (1) picpic
    17. Ribosomal protein S10 [54999] (1) picpic
    18. N-utilization substance G protein NusG, N-terminal domain [82679] (1) picpic
    19. PAP/Archaeal CCA-adding enzyme, C-terminal domain [55003] (2) picpic
    20. HMA, heavy metal-associated domain [55008] (1) picpic
    21. Urease metallochaperone UreE, C-terminal domain [69737] (1) picpic
    22. ACT-like [55021] (12) picpic
      regulatory domain linked to a wide range of metabolic enzymes
    23. Bacterial exopeptidase dimerisation domain [55031] (1) picpic
    24. NAD-binding domain of HMG-CoA reductase [55035] (1) picpic
    25. Molybdenum cofactor biosynthesis protein C, MoaC [55040] (1) picpic
    26. TRADD, N-terminal domain [55044] (1) picpic
    27. Probable ACP-binding domain of malonyl-CoA ACP transacylase [55048] (1) picpic
    28. CheY-binding domain of CheA [55052] (1) picpic
    29. D-ribose-5-phosphate isomerase (RpiA), lid domain [75445] (1) picpic
    30. Killer toxin KP6 alpha-subunit [55056] (1) picpic
    31. Hypothetical protein VC0424 [89946] (1) picpic
    32. Hypothetical protein TT1725 [103007] (1) picpic
    33. Mechanosensitive channel protein MscS (YggB), C-terminal domain [82689] (1) picpic
      the last strand of the fold is flipped away and involved in oligomerisation
    34. GHMP Kinase, C-terminal domain [55060] (7) picpic
      common fold is elaborated with additional secondary structures
    35. Translational regulator protein regA [55064] (1) picpic
      common fold is elaborated with additional secondary structures
    36. Peptide methionine sulfoxide reductase [55068] (1) picpic
      common fold is elaborated with additional secondary structures