Structural Classification of Proteins
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Fold: beta-Grasp (ubiquitin-like)

core: beta(2)-alpha-beta(2); mixed beta-sheet 2143

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a+b) [53931]
    Mainly antiparallel beta sheets (segregated alpha and beta regions)
  3. Fold: beta-Grasp (ubiquitin-like) [54235]
    core: beta(2)-alpha-beta(2); mixed beta-sheet 2143

Superfamilies:

  1. Ubiquitin-like [54236] (7)
    1. Ubiquitin-related [54237] (47) picpic
      Pfam 00240
    2. UBX domain [54250] (5) picpic
      Pfam 00789
    3. GABARAP-like [54253] (5) picpic
      intracellular membrane trafficking and fusion proteins
    4. First domain of FERM [54256] (7) picpic
    5. Ras-binding domain, RBD [54263] (16) picpic
      contains Pfam 00788 and Pfam 02196
    6. BM-002-like [75362] (3) picpic
      Pfam 03671; UPF0185; this family comprises small uncharacterized proteins including human protein BM-002
    7. APG12-like [142972] (1) picpic
      Pfam 04110
  2. CAD & PB1 domains [54277] (2)
    contain extra helix; similar heterodimerization modes; possibly related to the ubiquitin-like superfamily
    1. CAD domain [54278] (5) picpic
    2. PB1 domain [64225] (11) picpic
      Pfam 00564
      forms heterodimers, although not all PB1 domain pairs associate.
  3. MoaD/ThiS [54285] (3)
    possible link between the ubiquitin-like and 2Fe-2S ferredoxin-like superfamilies
    1. MoaD [54286] (3) picpic
    2. ThiS [54289] (4) picpic
    3. C9orf74 homolog [117833] (1) picpic
  4. TGS-like [81271] (2)
    possibly related to the ubiquitin-like and MoaD/ThiS superfamilies; some similarity to the alpha-L RNA-binding motif
    1. TGS domain [81270] (2) picpic
    2. G domain-linked domain [82583] (3) picpic
  5. 2Fe-2S ferredoxin-like [54292] (2)
    1. 2Fe-2S ferredoxin-related [54293] (19) picpic
    2. 2Fe-2S ferredoxin domains from multidomain proteins [54312] (16) picpic
  6. Staphylokinase/streptokinase [54328] (1)
    1. Staphylokinase/streptokinase [54329] (2) picpic
  7. Doublecortin (DC) [89837] (1)
    possibly related to the ubiquitin-like superfamily
    1. Doublecortin (DC) [89838] (2) picpic
  8. Superantigen toxins, C-terminal domain [54334] (1)
    1. Superantigen toxins, C-terminal domain [54335] (14) picpic
  9. Immunoglobulin-binding domains [54358] (1)
    1. Immunoglobulin-binding domains [54359] (2) picpic
  10. Translation initiation factor IF3, N-terminal domain [54364] (1)
    1. Translation initiation factor IF3, N-terminal domain [54365] (1) picpic
  11. Glutamine synthetase, N-terminal domain [54368] (1)
    1. Glutamine synthetase, N-terminal domain [54369] (2) picpic
  12. TmoB-like [110814] (1)
    possibly related to the ubiquitin-like and/or 2Fe-2S ferredoxin-like superfamilies
    1. TmoB-like [110815] (1) picpic
      Pfam 06234
  13. Nqo1 middle domain-like [142984] (1)
    possibly evolved from 2Fe-2S ferredoxins; contains no iron-sulfur cluster
    1. Nqo1 middle domain-like [142985] (1) picpic
      C-terminal part of Pfam 01512
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MRC site Generated from scop database 1.73 with scopm 1.101 on Wed Nov 21 11:18:32 2007
Copyright © 1994-2007 The scop authors / scop@mrc-lmb.cam.ac.uk