Structural Classification of Proteins
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Fold: UBC-like

alpha-beta(4)-alpha(3); core: meander beta-sheet plus one helix 2

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a+b) [53931]
    Mainly antiparallel beta sheets (segregated alpha and beta regions)
  3. Fold: UBC-like [54494]
    alpha-beta(4)-alpha(3); core: meander beta-sheet plus one helix 2

Superfamilies:

  1. UBC-like [54495] (4)
    1. UBC-related [54496] (37)
      1. Ubiquitin conjugating enzyme, UBC [54497]
        1. Arabidopsis thaliana [TaxId: 3702] [54498] (1) picpic
        2. Baker's yeast (Saccharomyces cerevisiae), ubc1 [TaxId: 4932] [69685] (3) picpic
        3. Baker's yeast (Saccharomyces cerevisiae), ubc2 (RAD6) [TaxId: 4932] [54499] (1) picpic
        4. Baker's yeast (Saccharomyces cerevisiae), ubc4 [TaxId: 4932] [54500] (1) picpic
        5. Baker's yeast (Saccharomyces cerevisiae), ubc7 [TaxId: 4932] [54501] (1) picpic
        6. Baker's yeast (Saccharomyces cerevisiae), ubc13 [TaxId: 4932] [64239] (2) picpic
        7. Baker's yeast (Saccharomyces cerevisiae), mms2 [TaxId: 4932] [64241] (2) picpic
        8. Human (Homo sapiens), ubc13 [TaxId: 9606] [64240] (5) picpic
        9. Human (Homo sapiens), mms2 [TaxId: 9606] [64242] (3) picpic
        10. Human (Homo sapiens), ubch7 [TaxId: 9606] [54502] (2) picpic
        11. Human (Homo sapiens), ubc9 [TaxId: 9606] [54503] (9) picpic
          identical sequence in many other species
        12. Human (Homo sapiens), ubch10 [TaxId: 9606] [64243] (1) picpic
        13. Human (Homo sapiens), ubc2b [TaxId: 9606] [102840] (1) picpic
          E2-17 kDa
        14. Human (Homo sapiens), ubch5b [TaxId: 9606] [102841] (14) picpic
          E2-17 kDa 2
        15. Clam (Spisula solidissima), E-2C [TaxId: 6584] [54504] (1) picpic
        16. Nematode (Caenorhabditis elegans), E2-19 kDa [TaxId: 6239] [89862] (1) picpic
        17. Nematode (Caenorhabditis elegans), E2-21.5 kDa [TaxId: 6239] [102842] (2) picpic
        18. Human (Homo sapiens), ubch8 [TaxId: 9606] [117850] (1) picpic
        19. Human(Homo sapiens), E2 S [TaxId: 9606] [143048] (2) picpic
        20. Leishmania major [TaxId: 5664] [143049] (3) picpic
          Ubiquitin carrier protein 4, putative
        21. Human (Homo sapiens), E2 J2 [TaxId: 9606] [143050] (2) picpic
          ubc6 homologue
        22. Human (Homo sapiens), E2 variant 1 [TaxId: 9606] [143051] (5) picpic
        23. Human (Homo sapiens), E2 L6 [TaxId: 9606] [143052] (3) picpic
        24. Human (Homo sapiens), E2 U [TaxId: 9606] [143053] (1) picpic
        25. Human (Homo sapiens), E2 D3 [TaxId: 9606] [143054] (5) picpic
        26. Human (Homo sapiens), E2 H [TaxId: 9606] [143055] (2) picpic
        27. Human (Homo sapiens), E2 G1 [TaxId: 9606] [143056] (1) picpic
        28. Human (Homo sapiens), E2 T [TaxId: 9606] [143057] (1) picpic
          Hspc150
        29. Human (Homo sapiens), E2 M [TaxId: 9606] [143058] (1) picpic
          the extra N-terminal peptide, bound to the heterodimeric E1 enzyme for NEDD8, can be seen in the PDB entry 1tt5, chains E and F
        30. Toxoplasma gondii [TaxId: 5811] [143059] (1) picpic
        31. Caenorhabditis elegans, E2 2 [TaxId: 6239] [143060] (1) picpic
      2. Ubiquitin-protein ligase W (E2 W) [143061]
        forms segment-swapped dimer
        1. Human (Homo sapiens) [TaxId: 9606] [143062] (2) picpic
      3. Ubiquitin-conjugating enzyme E2-25 kDa, E2 domain [143063]
        ubc1 homologue; also contains the C-terminal UBA domain
        1. Human (Homo sapiens) [TaxId: 9606] [143064] (4) picpic
        2. Cow (Bos taurus) [TaxId: 9913] [143065] (2) picpic
      4. Hypothetical protein Tgtwinscan_2721, E2 domain [143066]
        1. Toxoplasma gondii [TaxId: 5811] [143067] (2) picpic
      5. Ubiquitin-conjugating enzyme E2 Q2, C-terminal domain [143068]
        this proteins contains the N-terminal RWD domain
        1. Human (Homo sapiens) [TaxId: 9606] [143069] (1) picpic
      6. Putative ubiquitin-conjugating enzyme, E2 domain [143070]
        1. Plasmodium chabaudi [TaxId: 5825] [143071] (1) picpic
    2. UEV domain [75383] (2)
      1. Tumor susceptibility gene 101 (TSG101) [75384]
        1. Human (Homo sapiens) [TaxId: 9606] [75385] (7) picpic
      2. Vacuolar protein sorting-associated [102843]
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [102844] (1) picpic
    3. RWD domain [110843] (1)
      Pfam 05773
      1. EIF2-alpha kinase 4 (GCN2-like protein) [110844]
        1. Mouse (Mus musculus) [TaxId: 10090] [110845] (1) picpic
    4. UFC1-like [143072] (1)
      1. Ufm1-conjugating enzyme 1, UFC1 [143073]
        aka cgi-126
        1. Human (Homo sapiens) [TaxId: 9606] [143074] (3) picpic
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MRC site Generated from scop database 1.73 with scopm 1.101 on Wed Nov 21 11:18:32 2007
Copyright © 1994-2007 The scop authors / scop@mrc-lmb.cam.ac.uk