Structural Classification of Proteins
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Fold: CBS-domain

core: beta-alpha-beta(4); 2 layers: alpha/beta

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a+b) [53931]
    Mainly antiparallel beta sheets (segregated alpha and beta regions)
  3. Fold: CBS-domain [54630]
    core: beta-alpha-beta(4); 2 layers: alpha/beta

Superfamilies:

  1. CBS-domain [54631] (1)
    1. CBS-domain [54632] (13)
      Pfam 00571; pairs of CBS domains dimerize to form a stable globular domain
      1. Hypothetical protein TM0935 [102895]
        1. Thermotoga maritima [TaxId: 2336] [102896] (1)
          1. 1o50 picpic
            structural genomics
            1. region a:-2-69 [92478] picpiclink
            2. region a:77-145 [92479] picpiclink
      2. Hypothetical protein MTH1622 [102897]
        1. Archaeon Methanobacterium thermoautotrophicum [TaxId: 145262] [102898] (1)
          1. 1pbj picpic
            structural genomics
            complexed with mg
            1. region a:2-60 [94414] picpiclink
            2. region a:61-121 [94415] picpiclink
      3. Hypothetical protein Ta0289 [102899]
        contains extra C-terminal zinc-finger domain
        1. Archaeon Thermoplasma acidophilum [TaxId: 2303] [102900] (1)
          1. 1pvm picpicxref
            structural genomics
            complexed with hg
            1. region a:1-64 [95171] picpiclink
            2. region a:65-142 [95172] picpiclink
            3. region b:-5-64 [95174] picpiclink
            4. region b:65-142 [95175] picpiclink
      4. Type II inosine monophosphate dehydrogenase CBS domains [54633]
        contains tandem repeat of two CBS domains inserted into the catalytic TIM-barrel domain; may be disordered in the crystals
        1. Human (Homo sapiens), type I [TaxId: 9606] [89899] (1)
          1. 1jcn picpicxref
            both CBS domains are partly disordered in both chains, A and B
            complexed with cpr
            1. region a:112-164 [84161] picpiclink
            2. region a:181-231 [84162] picpiclink
            3. region b:112-164 [84164] picpiclink
            4. region b:181-231 [84165] picpiclink
        2. Human (Homo sapiens), type II [TaxId: 9606] [54634] (3)
          1. 1b3o picpicxref
            complexed with cpr, sae
            1. region b:112-159 [38538] picpiclink
            2. region b:178-231 [38539] picpiclink
          2. 1nf7 picpicxref
            both CBS domains are partly disordered in both chains, A and B
            complexed with k, myd, rvp
            1. region a:112-166 [91853] picpiclink
            2. region a:170-231 [91854] picpiclink
            3. region b:112-166 [91856] picpiclink
            4. region b:170-231 [91857] picpiclink
          3. 1nfb picpicxref
            both CBS domains are partly disordered in both chains, A and B
            complexed with cpr, nad
            1. region a:112-152 [91859] picpiclink
            2. region a:188-231 [91860] picpiclink
            3. region b:112-152 [91862] picpiclink
            4. region b:188-231 [91863] picpiclink
        3. Chinese hamster (Cricetulus griseus) [TaxId: 10029] [64260] (1)
          1. 1jr1 picpicxref
            complexed with imp, k, moa
            1. region a:113-155 [63242] picpiclink
            2. region a:178-232 [63243] picpiclink
        4. Streptococcus pyogenes [TaxId: 1314] [54635] (1)
          1. 1zfj picpicxref
            complexed with imp
            1. region a:95-158 [38540] picpiclink
            2. region a:159-220 [38541] picpiclink
      5. Hypothetical protein YkuL [117881]
        1. Bacillus subtilis [TaxId: 1423] [117882] (1)
          1. 1yav picpic
            Structural genomics target
            complexed with so4
            1. region a:13-75 [116595] picpiclink
            2. region a:76-144 [116596] picpiclink
            3. region b:13-75 [116597] picpiclink
            4. region b:76-144 [116598] picpiclink
      6. Nuclear protein SNF4 [143134]
        duplication: comprises four CBS repeats
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [143135] (1)
          1. 2nyc picpic
            4th CBS repeat
            1. region a:181-265 [138812] picpiclink
      7. Hypothetical protein TM0892, CBS tandem [143136]
        1. Thermotoga maritima [TaxId: 2336] [143137] (4)
          1. 1vr9 picpic
            1. region a:1-60 [120446] picpiclink
          2. 1vr9 picpic
            1. region a:61-121 [120447] picpiclink
          3. 1vr9 picpic
            automatically matched to 1VR9 A:1-60
            1. region b:1-60 [120448] picpiclink
          4. 1vr9 picpic
            automatically matched to 1VR9 A:61-121
            1. region b:61-121 [120449] picpiclink
      8. Chloride channel protein, CBS tandem [143138]
        contains additional structures between the two CBS repeats
        1. Marbled electric ray (Torpedo marmorata) [TaxId: 7788] [143139] (4)
          1. 2d4z picpic
            1. region a:691-770 [131260] picpiclink
          2. 2d4z picpic
            1. region a:527-606 [131261] picpiclink
          3. 2d4z picpic
            automatically matched to 2D4Z A:691-770
            1. region b:691-770 [131262] picpiclink
          4. 2d4z picpic
            automatically matched to 2D4Z A:527-606
            1. region b:527-606 [131263] picpiclink
      9. Hypothetical protein VC0737 [143140]
        Putative acetoin utilization protein AcuB
        1. Vibrio cholerae [TaxId: 666] [143141] (4)
          1. 2o16 picpic
            complexed with po4
            1. region a:20-82 [138869] picpiclink
          2. 2o16 picpic
            complexed with po4
            1. region a:92-158 [138870] picpiclink
          3. 2o16 picpic
            automatically matched to 2O16 A:20-82
            complexed with po4
            1. region b:20-80 [138871] picpiclink
          4. 2o16 picpic
            automatically matched to 2O16 A:92-158
            complexed with po4
            1. region b:92-158 [138872] picpiclink
      10. Hypothetical protein Rv2626c [143142]
        1. Mycobacterium tuberculosis [TaxId: 1773] [143143] (8)
          1. 1y5h picpic
            1. region a:69-124 [122635] picpiclink
          2. 1y5h picpic
            1. region a:2-68 [122636] picpiclink
          3. 1y5h picpic
            automatically matched to 1Y5H A:69-124
            1. region b:69-123 [122637] picpiclink
          4. 1y5h picpic
            automatically matched to 1Y5H A:2-68
            1. region b:2-68 [122638] picpiclink
          5. 1xkf picpic
            complexed with zn
            1. region a:2-68 [122077] picpiclink
          6. 1xkf picpic
            complexed with zn
            1. region a:69-124 [122078] picpiclink
          7. 1xkf picpic
            automatically matched to 1XKF A:2-68
            complexed with zn
            1. region b:2-68 [122079] picpiclink
          8. 1xkf picpic
            automatically matched to 1XKF A:69-124
            complexed with zn
            1. region b:69-123 [122080] picpiclink
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MRC site Generated from scop database 1.73 with scopm 1.101 on Wed Nov 21 11:18:32 2007
Copyright © 1994-2007 The scop authors / scop@mrc-lmb.cam.ac.uk