Structural Classification of Proteins
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Fold: C2H2 and C2HC zinc fingers

alpha+beta metal(zinc)-bound fold: beta-hairpin + alpha-helix

Lineage:

  1. Root: scop
  2. Class: Small proteins [56992]
    Usually dominated by metal ligand, heme, and/or disulfide bridges
  3. Fold: C2H2 and C2HC zinc fingers [57666]
    alpha+beta metal(zinc)-bound fold: beta-hairpin + alpha-helix

Superfamilies:

  1. C2H2 and C2HC zinc fingers [57667] (6)
    1. Classic zinc finger, C2H2 [57668] (30)
      1. ZIF268 [57669]
        duplication: consists of 3 fingers
        1. Mouse (Mus musculus) [TaxId: 10090] [57670] (14) picpic
      2. V(D)J recombination activating protein 1 (RAG1), dimerization domain [57671]
        1. Mouse (Mus musculus) [TaxId: 10090] [57672] (1) picpic
      3. Tramtrack protein (two zinc-finger peptide) [57673]
        1. Drosophila melanogaster [TaxId: 7227] [57674] (1) picpic
      4. ADR1 [57675]
        1. Synthetic, based on Saccharomyces cerevisiae sequence [57676] (5) picpic
      5. XFIN, third domain [57677]
        1. Xenopus laevis [TaxId: 8355] [57678] (1) picpic
      6. ZFY [57679]
        1. Human (Homo sapiens) [TaxId: 9606] [57680] (5) picpic
      7. SWI5 zinc-finger domains [57681]
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [57682] (2) picpic
      8. Five-finger GLI1 [57683]
        1. Human (Homo sapiens) [TaxId: 9606] [57684] (1) picpic
      9. Enhancer binding protein [57685]
        duplication: consists of two Zn fingers
        1. Human (Homo sapiens) [TaxId: 9606] [57686] (3) picpic
      10. Transcription factor sp1 [57687]
        1. Human (Homo sapiens) [TaxId: 9606] [57688] (4) picpic
      11. Transactivation domain of cre-bp1/atf-2 [57689]
        1. Human (Homo sapiens) [TaxId: 9606] [57690] (1) picpic
      12. Ying-yang 1 (yy1, zinc finger domain) [57691]
        duplication: consists of 4 fingers
        1. Human (Homo sapiens) [TaxId: 9606] [57692] (1) picpic
      13. Transcription factor IIIA, TFIIIA [57693]
        duplication: consists of 6 fingers
        1. Xenopus laevis [TaxId: 8355] [57694] (6) picpic
      14. GAGA factor [57695]
        1. Drosophila melanogaster [TaxId: 7227] [57696] (2) picpic
      15. Kruppel-like factor 3, Bklf [103597]
        1. Mouse (Mus musculus) [TaxId: 10090] [103598] (3) picpic
      16. Zinc finger protein ZFPM1 (FOG-1) [111434]
        1. Mouse (Mus musculus) [TaxId: 10090] [111435] (1) picpic
      17. Zinc finger protein 295, ZNF295 [118267]
        1. Human (Homo sapiens) [TaxId: 9606] [118268] (1) picpic
      18. Wilms' tumor protein, WT1 [118269]
        1. Human (Homo sapiens) [TaxId: 9606] [118270] (1) picpic
      19. Zinc finger protein 292, ZNF292 [144133]
        1. Human (Homo sapiens) [TaxId: 9606] [144134] (1) picpic
      20. Zinc finger protein 512, ZNF512 [144135]
        1. Human (Homo sapiens) [TaxId: 9606] [144136] (2) picpic
      21. Zinc finger protein 462, ZNF462 [144137]
        1. Human (Homo sapiens) [TaxId: 9606] [144138] (1) picpic
      22. Zinc finger protein 692, ZNF692 [144139]
        1. Human (Homo sapiens) [TaxId: 9606] [144140] (2) picpic
      23. Zinc fingers and homeoboxes protein 1, ZHX1 [144141]
        1. Human (Homo sapiens) [TaxId: 9606] [144142] (2) picpic
      24. Zinc finger protein 24 [144143]
        1. Human (Homo sapiens) [TaxId: 9606] [144144] (2) picpic
      25. Zinc finger protein 297b [144145]
        1. Human (Homo sapiens) [TaxId: 9606] [144146] (2) picpic
      26. GLI-Krueppel family member HKR3 [144147]
        ZBTB48
        1. Mouse (Mus musculus) [TaxId: 10090] [144148] (4) picpic
      27. Zinc finger protein 64, ZFP68 [144149]
        1. Human (Homo sapiens) [TaxId: 9606] [144150] (5) picpic
      28. Zinc finger protein 593, ZNF593 [144151]
        1. Human (Homo sapiens) [TaxId: 9606] [144152] (1) picpic
      29. Transcriptional repressor CTCF [144153]
        1. Human (Homo sapiens) [TaxId: 9606] [144154] (4) picpic
      30. Zinc finger and SCAN domain-containing protein 16, ZSCAN16 [144155]
        Zinc finger protein 435
        1. Human (Homo sapiens) [TaxId: 9606] [144156] (2) picpic
    2. Plant C2H2 finger (QALGGH zinc finger) [90198] (1)
      1. SUPERMAN zinc finger domain [90199]
        1. Arabidopsis thaliana [TaxId: 3702] [90200] (1) picpic
    3. C2HC finger [57697] (3)
      1. U-shaped transcription factor, different fingers [57698]
        1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [57699] (4) picpic
      2. Monocytic leukemia zinc finger protein Moz [103599]
        1. Human (Homo sapiens) [TaxId: 9606] [103600] (1) picpic
      3. Cell growth regulating nucleolar protein LyaR [118271]
        1. Mouse (Mus musculus) [TaxId: 10090] [118272] (1) picpic
    4. Spliceosomal protein U1C [111436] (1)
      1. Spliceosomal protein U1C [111437]
        1. Human (Homo sapiens) [TaxId: 9606] [111438] (1) picpic
    5. variant C2H2 finger [118273] (1)
      contains extra C-terminal, alpha-helical subdomain
      1. Protein arginine N-methyltransferase 3 [118274]
        1. Mouse (Mus musculus) [TaxId: 10090] [118275] (1) picpic
    6. BED zinc finger [144157] (1)
      Pfam 02892; contains extra N-terminal and C-terminal helices bundled together with the core helix
      1. Zinc finger BED domain-containing protein 1 [144158]
        dREF homolog
        1. Human (Homo sapiens) [TaxId: 9606] [144159] (1) picpic
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MRC site Generated from scop database 1.73 with scopm 1.101 on Wed Nov 21 11:18:32 2007
Copyright © 1994-2007 The scop authors / scop@mrc-lmb.cam.ac.uk